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PMID:16754836

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Citation

Olincy, A, Harris, JG, Johnson, LL, Pender, V, Kongs, S, Allensworth, D, Ellis, J, Zerbe, GO, Leonard, S, Stevens, KE, Stevens, JO, Martin, L, Adler, LE, Soti, F, Kem, WR and Freedman, R (2006) Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch. Gen. Psychiatry 63:630-8

Abstract

The alpha7 nicotinic acetylcholine receptor gene, CHRNA7, is associated with genetic transmission of schizophrenia and related cognitive and neurophysiological sensory gating deficits. Cognitive dysfunction is responsible for significant psychosocial disability in schizophrenia. Nicotine, a low-potency agonist at the alpha7 receptor, has some positive effects on neurophysiological and neurocognitive deficits associated with schizophrenia, which suggests that more effective receptor activation might meaningfully enhance cognition in schizophrenia.

Links

PubMed Online version:10.1001/archpsyc.63.6.630

Keywords

Adult; Benzylidene Compounds/therapeutic use; Cognition Disorders/diagnosis; Cognition Disorders/drug therapy; Cognition Disorders/psychology; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Evoked Potentials, Auditory/drug effects; Female; Humans; Male; Neuropsychological Tests/statistics & numerical data; Nicotinic Agonists/therapeutic use; Placebos; Psychiatric Status Rating Scales; Pyridines/therapeutic use; Receptors, Nicotinic/drug effects; Schizophrenia/drug therapy; Schizophrenic Psychology; Severity of Illness Index

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ACHA7

involved_in

GO:0050890: cognition

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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