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HUMAN:ACES
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ACHE | |
| Protein Name(s) | Acetylcholinesterase
AChE | |
| External Links | ||
| UniProt | P22303 | |
| EMBL | M55040 S71129 AF334270 AK291321 AK223443 AY750146 AC011895 AC011895 CH236956 CH236956 CH471091 CH471091 CH471091 BC036813 BC105060 BC105062 BC143469 AF312032 | |
| CCDS | CCDS5709.1 CCDS5710.1 CCDS64736.1 | |
| PIR | A39256 | |
| RefSeq | NP_000656.1 NP_001269378.1 NP_056646.1 XP_006716058.1 | |
| UniGene | Hs.154495 | |
| PDB | 1B41 1F8U 1PUV 1PUW 1VZJ 2CLJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8 4M0E 4M0F | |
| PDBsum | 1B41 1F8U 1PUV 1PUW 1VZJ 2CLJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8 4M0E 4M0F | |
| ProteinModelPortal | P22303 | |
| SMR | P22303 | |
| BioGrid | 106561 | |
| DIP | DIP-1119N | |
| IntAct | P22303 | |
| MINT | MINT-149019 | |
| BindingDB | P22303 | |
| ChEMBL | CHEMBL2095233 | |
| DrugBank | DB01122 DB00122 DB01245 DB00944 DB00449 DB00843 DB01010 DB01364 DB00674 DB00483 DB00677 DB00358 DB00805 DB01400 DB00981 DB00733 DB00545 DB00989 DB01199 | |
| GuidetoPHARMACOLOGY | 2465 | |
| MEROPS | S09.979 | |
| PhosphoSite | P22303 | |
| DMDM | 113037 | |
| SWISS-2DPAGE | P22303 | |
| PaxDb | P22303 | |
| PRIDE | P22303 | |
| Ensembl | ENST00000241069 ENST00000302913 ENST00000411582 ENST00000412389 ENST00000419336 ENST00000428317 | |
| GeneID | 43 | |
| KEGG | hsa:43 | |
| UCSC | uc003uxd.3 uc003uxe.3 uc003uxh.3 | |
| CTD | 43 | |
| GeneCards | GC07M100487 | |
| HGNC | HGNC:108 | |
| HPA | HPA019704 | |
| MIM | 100740 112100 | |
| neXtProt | NX_P22303 | |
| PharmGKB | PA20 | |
| eggNOG | COG2272 | |
| GeneTree | ENSGT00760000118946 | |
| HOVERGEN | HBG008839 | |
| InParanoid | P22303 | |
| KO | K01049 | |
| OMA | RPPWCPL | |
| OrthoDB | EOG789C9R | |
| PhylomeDB | P22303 | |
| TreeFam | TF315470 | |
| Reactome | REACT_121238 REACT_13583 REACT_19189 | |
| SABIO-RK | P22303 | |
| ChiTaRS | ACHE | |
| EvolutionaryTrace | P22303 | |
| GeneWiki | Acetylcholinesterase | |
| GenomeRNAi | 43 | |
| NextBio | 173 | |
| PRO | PR:P22303 | |
| Proteomes | UP000005640 | |
| Bgee | P22303 | |
| ExpressionAtlas | P22303 | |
| Genevestigator | P22303 | |
| GO | GO:0031225 GO:0030424 GO:0005605 GO:0030054 GO:0009986 GO:0030425 GO:0005788 GO:0005576 GO:0005615 GO:0005794 GO:0016020 GO:0031594 GO:0005634 GO:0048471 GO:0005886 GO:0045211 GO:0042734 GO:0045202 GO:0042166 GO:0003990 GO:0001540 GO:0004104 GO:0005518 GO:0016787 GO:0043236 GO:0042803 GO:0017171 GO:0006581 GO:0001507 GO:0042982 GO:0007155 GO:0008283 GO:0019695 GO:0006260 GO:0046474 GO:0007517 GO:0032223 GO:0007399 GO:0042136 GO:0045212 GO:0002076 GO:0006656 GO:0006644 GO:0050714 GO:0051262 GO:0031623 GO:0050770 GO:0048814 GO:0001919 GO:0009611 GO:0060041 GO:0044281 GO:0007416 GO:0007268 GO:0007271 | |
| Gene3D | 3.40.50.1820 | |
| InterPro | IPR029058 IPR014788 IPR002018 IPR019826 IPR019819 IPR000997 | |
| Pfam | PF08674 PF00135 | |
| PRINTS | PR00878 | |
| ProDom | PD415333 | |
| SUPFAM | SSF53474 | |
| PROSITE | PS00122 PS00941 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0050435 |
beta-amyloid metabolic process |
ECO:0000314 |
P |
THC is an inhibitor of AChE which leads to a decrease of beta-amyloid accumulation. |
complete | |||||
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043236 |
laminin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042166 |
acetylcholine binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032223 |
negative regulation of synaptic transmission, cholinergic |
ECO:0000305 |
curator inference used in manual assertion |
GO:0006581 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017171 |
serine hydrolase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006581 |
acetylcholine catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005518 |
collagen binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004104 |
cholinesterase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003990 |
acetylcholinesterase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002076 |
osteoblast development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042166 |
acetylcholine binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003990 |
acetylcholinesterase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001507 |
acetylcholine catabolic process in synaptic cleft |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000592 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95420 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043083 |
synaptic cleft |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0001507 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060041 |
retina development in camera-type eye |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051262 |
protein tetramerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045212 |
neurotransmitter receptor biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202 |
synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043621 |
protein self-association |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043236 |
laminin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031623 |
receptor internalization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031594 |
neuromuscular junction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006581 |
acetylcholine catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003990 |
acetylcholinesterase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001919 |
regulation of receptor recycling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21836 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004104 |
cholinesterase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003990 |
acetylcholinesterase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050714 |
positive regulation of protein secretion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042982 |
amyloid precursor protein metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009611 |
response to wounding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007517 |
muscle organ development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007416 |
synapse assembly |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006260 |
DNA replication |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001540 |
amyloid-beta binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042136 |
neurotransmitter biosynthetic process |
Reactome:R-HSA-112311 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006656 |
phosphatidylcholine biosynthetic process |
Reactome:R-HSA-1483191 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-372519 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031225 |
anchored component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042135 |
neurotransmitter catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Eubanks, LM et al. () A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol. Pharm. 3 773-7 PubMed GONUTS page
- ↑ Sun, M et al. (2007) Reduced nicotinic receptor function in sympathetic ganglia is responsible for the hypothermia in the acetylcholinesterase knockout mouse. J. Physiol. (Lond.) 578 751-64 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Johnson, G & Moore, SW (2003) Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site. Neurosci. Lett. 337 37-40 PubMed GONUTS page
- ↑ Schallreuter, KU et al. (2004) Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo. Biochem. Biophys. Res. Commun. 315 502-8 PubMed GONUTS page
- ↑ Ben Aziz-Aloya, R et al. (1993) Expression of a human acetylcholinesterase promoter-reporter construct in developing neuromuscular junctions of Xenopus embryos. Proc. Natl. Acad. Sci. U.S.A. 90 2471-5 PubMed GONUTS page
- ↑ Ordentlich, A et al. (1993) Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket. J. Biol. Chem. 268 17083-95 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 Shafferman, A et al. (1992) Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. J. Biol. Chem. 267 17640-8 PubMed GONUTS page
- ↑ Bazelyansky, M et al. (1986) Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase. Biochemistry 25 125-30 PubMed GONUTS page
- ↑ Carvalho, FA et al. (2005) Biochemical characterization of human umbilical vein endothelial cell membrane bound acetylcholinesterase. FEBS J. 272 5584-94 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Inkson, CA et al. (2004) Characterization of acetylcholinesterase expression and secretion during osteoblast differentiation. Bone 35 819-27 PubMed GONUTS page
- ↑ Guerra, M et al. (2005) Acetylcholinesterase and molecular interactions at the neuromuscular junction. Chem. Biol. Interact. 157-158 57-61 PubMed GONUTS page
- ↑ 12.0 12.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 13.5 13.6 13.7 13.8 13.9 Soreq, H & Seidman, S (2001) Acetylcholinesterase--new roles for an old actor. Nat. Rev. Neurosci. 2 294-302 PubMed GONUTS page
- ↑ Pakaski, M & Kasa, P (2003) Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein. Curr Drug Targets CNS Neurol Disord 2 163-71 PubMed GONUTS page
a
- GO:0042166 ! acetylcholine binding
- GO:0001507 ! acetylcholine catabolic process in synaptic cleft
- GO:0003990 ! acetylcholinesterase activity
- GO:0006581 ! acetylcholine catabolic process
- GO:0050435 ! amyloid-beta metabolic process
- GO:0001540 ! amyloid-beta binding
- GO:0042982 ! amyloid precursor protein metabolic process
c
e
n
o
- GO:0031225 ! obsolete anchored component of membrane
- GO:0045212 ! obsolete neurotransmitter receptor biosynthetic process
- GO:0042136 ! obsolete neurotransmitter biosynthetic process
- GO:0042135 ! obsolete neurotransmitter catabolic process
- GO:0043621 ! obsolete protein self-association
- GO:0002076 ! osteoblast development
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0006656 ! phosphatidylcholine biosynthetic process
- GO:0005886 ! plasma membrane
- GO:0120162 ! positive regulation of cold-induced thermogenesis
- GO:0050714 ! positive regulation of protein secretion
- Primates
- GO:0042803 ! protein homodimerization activity
- GO:0051262 ! protein tetramerization
r
s
