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PMID:11283752

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Citation

Soreq, H and Seidman, S (2001) Acetylcholinesterase--new roles for an old actor. Nat. Rev. Neurosci. 2:294-302

Abstract

The discovery of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminating acetylcholine-mediated neurotransmission made it the focus of intense research for much of the past century. But the complexity of acetylcholinesterase gene regulation and recent evidence for some of the long-suspected 'non-classical' actions of this enzyme have more recently driven a profound revolution in acetylcholinesterase research. Although our understanding of the additional roles of acetylcholinesterase is incomplete, the time is ripe to summarize the evidence on a remarkable diversity of acetylcholinesterase functions.

Links

PubMed Online version:10.1038/35067589

Keywords

Acetylcholinesterase/chemistry; Acetylcholinesterase/genetics; Acetylcholinesterase/metabolism; Alternative Splicing/genetics; Animals; Cell Adhesion; Cholinesterase Inhibitors/pharmacology; Dopamine/metabolism; Gene Expression Regulation, Enzymologic; Hematopoiesis; Humans; Multienzyme Complexes/chemistry; Multienzyme Complexes/genetics; Multienzyme Complexes/metabolism; Mutation/genetics; Neurodegenerative Diseases/enzymology; Neurodegenerative Diseases/genetics; Neurons/enzymology; Neurons/metabolism; Persian Gulf Syndrome/enzymology; Phenotype; Plaque, Amyloid/metabolism; Protein Transport; Stress, Physiological/enzymology; Synapses/enzymology; Synapses/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ACES

located_in

GO:0005576: extracellular region

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:ACES

involved_in

GO:0050714: positive regulation of protein secretion

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ACES

involved_in

GO:0009611: response to wounding

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ACES

involved_in

GO:0008283: cell population proliferation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ACES

involved_in

GO:0007517: muscle organ development

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ACES

involved_in

GO:0007416: synapse assembly

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ACES

involved_in

GO:0007399: nervous system development

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ACES

involved_in

GO:0007155: cell adhesion

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ACES

involved_in

GO:0006260: DNA replication

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ACES

part_of

GO:0005576: extracellular region

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:ACES

enables

GO:0001540: amyloid-beta binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete


See also

References

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