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HUMAN:ABC3H

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) APOBEC3H
Protein Name(s) DNA dC->dU-editing enzyme APOBEC-3H

APOBEC-related protein 10 ARP-10 Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H A3H

External Links
UniProt Q6NTF7
EMBL FJ376613
CR456481
AL031846
BC069023
BQ052182
CCDS CCDS13985.1
CCDS54530.1
CCDS54531.1
CCDS54532.1
RefSeq NP_001159474.2
NP_001159475.2
NP_001159476.2
NP_861438.3
UniGene Hs.440515
ProteinModelPortal Q6NTF7
SMR Q6NTF7
STRING 9606.ENSP00000344182
PhosphoSite Q6NTF7
DMDM 205371798
PaxDb Q6NTF7
PRIDE Q6NTF7
DNASU 164668
Ensembl ENST00000348946
ENST00000401756
ENST00000421988
ENST00000442487
GeneID 164668
KEGG hsa:164668
UCSC uc021wpt.1
uc021wpu.1
uc021wpv.1
CTD 164668
GeneCards GC22P039493
HGNC HGNC:24100
HPA HPA021492
MIM 610976
neXtProt NX_Q6NTF7
PharmGKB PA162376694
eggNOG NOG135704
HOGENOM HOG000033754
HOVERGEN HBG050434
OMA DETQCYQ
OrthoDB EOG7W154V
PhylomeDB Q6NTF7
TreeFam TF331356
GeneWiki APOBEC3H
GenomeRNAi 164668
NextBio 33762998
PRO PR:Q6NTF7
Proteomes UP000005640
Bgee Q6NTF7
CleanEx HS_APOBEC3H
ExpressionAtlas Q6NTF7
Genevestigator Q6NTF7
GO GO:0005737
GO:0000932
GO:0005634
GO:0004126
GO:0008270
GO:0009972
GO:0051607
GO:0070383
GO:0002244
GO:0045087
GO:0045869
GO:0010529
GO:0048525
InterPro IPR016192
IPR007904
IPR002125
IPR016193
Pfam PF05240
PF00383
SUPFAM SSF53927
PROSITE PS00903

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0070383

DNA cytosine deamination

PMID:21835787[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070383

DNA cytosine deamination

PMID:16571802[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:22915799[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21835787[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:22457529[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048525

negative regulation of viral process

PMID:18827027[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045869

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

PMID:21835787[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045869

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

PMID:18779051[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010529

negative regulation of transposition

PMID:18827027[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010529

negative regulation of transposition

PMID:20062055[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010529

negative regulation of transposition

PMID:18779051[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21835787[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18779051[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18779051[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004126

cytidine deaminase activity

PMID:16571802[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000932

P-body

PMID:22915799[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0080111

DNA demethylation

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103298
PANTHER:PTN000355219
UniProtKB:P31941
UniProtKB:Q8IUX4
UniProtKB:Q9GZX7
UniProtKB:Q9NRW3
UniProtKB:Q9Y235

P

Seeded From UniProt

complete

involved_in

GO:0016554

cytidine to uridine editing

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103298
MGI:MGI:1343178
PANTHER:PTN000355219
RGD:2133
UniProtKB:Q9Y235

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1933111
PANTHER:PTN000355219
RGD:2133
UniProtKB:P31941
UniProtKB:P41238
UniProtKB:Q19Q52
UniProtKB:Q6NTF7
UniProtKB:Q7YR23
UniProtKB:Q8IUX4
UniProtKB:Q96AK3
UniProtKB:Q9GZX7
UniProtKB:Q9HC16
UniProtKB:Q9NRW3

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000355219
RGD:2133
UniProtKB:P31941
UniProtKB:Q6NTF7
UniProtKB:Q9GZX7
UniProtKB:Q9NRW3
UniProtKB:Q9UH17

C

Seeded From UniProt

complete

enables

GO:0004126

cytidine deaminase activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1342279
MGI:MGI:1343178
PANTHER:PTN000355219
RGD:2133
UniProtKB:P31941
UniProtKB:Q19Q52
UniProtKB:Q6NTF7
UniProtKB:Q8IUX4
UniProtKB:Q9GZX7
UniProtKB:Q9Y235

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000355219
UniProtKB:Q8IUX4
UniProtKB:Q9HC16

F

Seeded From UniProt

complete

involved_in

GO:0009972

cytidine deamination

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004126

P

Seeded From UniProt

complete

involved_in

GO:0009972

cytidine deamination

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004126

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016193

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016192

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016192

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0000932

P-body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0230

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Hultquist, JF et al. (2011) Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1. J. Virol. 85 11220-34 PubMed GONUTS page
  2. ↑ 2.0 2.1 OhAinle, M et al. (2006) Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H. J. Virol. 80 3853-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 Phalora, PK et al. (2012) HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. J. Virol. 86 11712-24 PubMed GONUTS page
  4. ↑ Ooms, M et al. (2012) APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1. J. Virol. 86 6097-108 PubMed GONUTS page
  5. ↑ 5.0 5.1 Tan, L et al. (2009) Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1. FASEB J. 23 279-87 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 OhAinle, M et al. (2008) Antiretroelement activity of APOBEC3H was lost twice in recent human evolution. Cell Host Microbe 4 249-59 PubMed GONUTS page
  7. ↑ Stenglein, MD et al. (2010) APOBEC3 proteins mediate the clearance of foreign DNA from human cells. Nat. Struct. Mol. Biol. 17 222-9 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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