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HUMAN:ABC3C

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) APOBEC3C (synonyms: APOBEC1L, PBI)
Protein Name(s) DNA dC->dU-editing enzyme APOBEC-3C

A3C APOBEC1-like Phorbolin I

External Links
UniProt Q9NRW3
EMBL AF165520
CR456394
AK313272
AL022318
CH471095
BC011739
BC021080
CCDS CCDS13983.1
RefSeq NP_055323.2
UniGene Hs.441124
PDB 3VM8
3VOW
PDBsum 3VM8
3VOW
ProteinModelPortal Q9NRW3
SMR Q9NRW3
BioGrid 118162
DIP DIP-48919N
IntAct Q9NRW3
MINT MINT-6631470
STRING 9606.ENSP00000355340
PhosphoSite Q9NRW3
DMDM 48474983
MaxQB Q9NRW3
PaxDb Q9NRW3
PRIDE Q9NRW3
DNASU 27350
Ensembl ENST00000361441
GeneID 27350
KEGG hsa:27350
UCSC uc003awr.3
CTD 27350
GeneCards GC22P039410
HGNC HGNC:17353
HPA CAB033048
MIM 607750
neXtProt NX_Q9NRW3
PharmGKB PA24893
eggNOG NOG289247
GeneTree ENSGT00530000062933
HOGENOM HOG000033754
HOVERGEN HBG050434
KO K01500
OMA SETHCHA
PhylomeDB Q9NRW3
TreeFam TF331356
ChiTaRS APOBEC3C
GeneWiki APOBEC3C
GenomeRNAi 27350
NextBio 50452
PRO PR:Q9NRW3
Proteomes UP000005640
Bgee Q9NRW3
CleanEx HS_APOBEC3C
ExpressionAtlas Q9NRW3
Genevestigator Q9NRW3
GO GO:0005737
GO:0005634
GO:0016814
GO:0044822
GO:0008270
GO:0009972
GO:0051607
GO:0080111
GO:0045087
GO:0010529
GO:0045071
GO:0016032
InterPro IPR016192
IPR007904
IPR016193
Pfam PF05240
SUPFAM SSF53927
PROSITE PS00903

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0080111

DNA demethylation

PMID:21496894[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:21632763[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010529

negative regulation of transposition

PMID:20062055[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010529

negative regulation of transposition

PMID:16527742[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009972

cytidine deamination

PMID:21632763[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21835787[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21835787[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0080111

DNA demethylation

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103298
PANTHER:PTN000355219
UniProtKB:P31941
UniProtKB:Q8IUX4
UniProtKB:Q9GZX7
UniProtKB:Q9NRW3
UniProtKB:Q9Y235

P

Seeded From UniProt

complete

involved_in

GO:0070383

DNA cytosine deamination

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001419581
UniProtKB:Q8IUX4
UniProtKB:Q96AK3

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001419581
UniProtKB:Q8IUX4
UniProtKB:Q96AK3

P

Seeded From UniProt

complete

involved_in

GO:0045869

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001419581
UniProtKB:Q8IUX4
UniProtKB:Q96AK3

P

Seeded From UniProt

complete

involved_in

GO:0016554

cytidine to uridine editing

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103298
MGI:MGI:1343178
PANTHER:PTN000355219
RGD:2133
UniProtKB:Q9Y235

P

Seeded From UniProt

complete

involved_in

GO:0010529

negative regulation of transposition

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001419581
UniProtKB:Q8IUX4
UniProtKB:Q96AK3
UniProtKB:Q9NRW3

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1933111
PANTHER:PTN000355219
RGD:2133
UniProtKB:P31941
UniProtKB:P41238
UniProtKB:Q19Q52
UniProtKB:Q6NTF7
UniProtKB:Q7YR23
UniProtKB:Q8IUX4
UniProtKB:Q96AK3
UniProtKB:Q9GZX7
UniProtKB:Q9HC16
UniProtKB:Q9NRW3

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000355219
RGD:2133
UniProtKB:P31941
UniProtKB:Q6NTF7
UniProtKB:Q9GZX7
UniProtKB:Q9NRW3
UniProtKB:Q9UH17

C

Seeded From UniProt

complete

enables

GO:0004126

cytidine deaminase activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1342279
MGI:MGI:1343178
PANTHER:PTN000355219
RGD:2133
UniProtKB:P31941
UniProtKB:Q19Q52
UniProtKB:Q6NTF7
UniProtKB:Q8IUX4
UniProtKB:Q9GZX7
UniProtKB:Q9Y235

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000355219
UniProtKB:Q8IUX4
UniProtKB:Q9HC16

F

Seeded From UniProt

complete

part_of

GO:0000932

P-body

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001419581
UniProtKB:Q8IUX4
UniProtKB:Q96AK3

C

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016193

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016192

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016192

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Guo, JU et al. (2011) Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145 423-34 PubMed GONUTS page
  2. 2.0 2.1 Suspène, R et al. (2011) Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo. J. Virol. 85 7594-602 PubMed GONUTS page
  3. Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  4. Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  5. Stenglein, MD et al. (2010) APOBEC3 proteins mediate the clearance of foreign DNA from human cells. Nat. Struct. Mol. Biol. 17 222-9 PubMed GONUTS page
  6. Chen, H et al. (2006) APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. Curr. Biol. 16 480-5 PubMed GONUTS page
  7. 7.0 7.1 Hultquist, JF et al. (2011) Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1. J. Virol. 85 11220-34 PubMed GONUTS page
  8. 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page