GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:ABC3C
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | APOBEC3C (synonyms: APOBEC1L, PBI) | |
| Protein Name(s) | DNA dC->dU-editing enzyme APOBEC-3C
A3C APOBEC1-like Phorbolin I | |
| External Links | ||
| UniProt | Q9NRW3 | |
| EMBL | AF165520 CR456394 AK313272 AL022318 CH471095 BC011739 BC021080 | |
| CCDS | CCDS13983.1 | |
| RefSeq | NP_055323.2 | |
| UniGene | Hs.441124 | |
| PDB | 3VM8 3VOW | |
| PDBsum | 3VM8 3VOW | |
| ProteinModelPortal | Q9NRW3 | |
| SMR | Q9NRW3 | |
| BioGrid | 118162 | |
| DIP | DIP-48919N | |
| IntAct | Q9NRW3 | |
| MINT | MINT-6631470 | |
| STRING | 9606.ENSP00000355340 | |
| PhosphoSite | Q9NRW3 | |
| DMDM | 48474983 | |
| MaxQB | Q9NRW3 | |
| PaxDb | Q9NRW3 | |
| PRIDE | Q9NRW3 | |
| DNASU | 27350 | |
| Ensembl | ENST00000361441 | |
| GeneID | 27350 | |
| KEGG | hsa:27350 | |
| UCSC | uc003awr.3 | |
| CTD | 27350 | |
| GeneCards | GC22P039410 | |
| HGNC | HGNC:17353 | |
| HPA | CAB033048 | |
| MIM | 607750 | |
| neXtProt | NX_Q9NRW3 | |
| PharmGKB | PA24893 | |
| eggNOG | NOG289247 | |
| GeneTree | ENSGT00530000062933 | |
| HOGENOM | HOG000033754 | |
| HOVERGEN | HBG050434 | |
| KO | K01500 | |
| OMA | SETHCHA | |
| PhylomeDB | Q9NRW3 | |
| TreeFam | TF331356 | |
| ChiTaRS | APOBEC3C | |
| GeneWiki | APOBEC3C | |
| GenomeRNAi | 27350 | |
| NextBio | 50452 | |
| PRO | PR:Q9NRW3 | |
| Proteomes | UP000005640 | |
| Bgee | Q9NRW3 | |
| CleanEx | HS_APOBEC3C | |
| ExpressionAtlas | Q9NRW3 | |
| Genevestigator | Q9NRW3 | |
| GO | GO:0005737 GO:0005634 GO:0016814 GO:0044822 GO:0008270 GO:0009972 GO:0051607 GO:0080111 GO:0045087 GO:0010529 GO:0045071 GO:0016032 | |
| InterPro | IPR016192 IPR007904 IPR016193 | |
| Pfam | PF05240 | |
| SUPFAM | SSF53927 | |
| PROSITE | PS00903 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0080111 |
DNA demethylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045071 |
negative regulation of viral genome replication |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010529 |
negative regulation of transposition |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010529 |
negative regulation of transposition |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009972 |
cytidine deamination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0080111 |
DNA demethylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103298 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070383 |
DNA cytosine deamination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001419581 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001419581 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045869 |
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001419581 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016554 |
cytidine to uridine editing |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103298 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010529 |
negative regulation of transposition |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001419581 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1933111 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000355219 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004126 |
cytidine deaminase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1342279 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000355219 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000932 |
P-body |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001419581 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Guo, JU et al. (2011) Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145 423-34 PubMed GONUTS page
- ↑ 2.0 2.1 Suspène, R et al. (2011) Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo. J. Virol. 85 7594-602 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ Stenglein, MD et al. (2010) APOBEC3 proteins mediate the clearance of foreign DNA from human cells. Nat. Struct. Mol. Biol. 17 222-9 PubMed GONUTS page
- ↑ Chen, H et al. (2006) APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. Curr. Biol. 16 480-5 PubMed GONUTS page
- ↑ 7.0 7.1 Hultquist, JF et al. (2011) Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1. J. Virol. 85 11220-34 PubMed GONUTS page
- ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
n
o
