HUMAN:AAPK2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PRKAA2 (synonyms: AMPK, AMPK2)
Protein Name(s)	5'-AMP-activated protein kinase catalytic subunit alpha-2 AMPK subunit alpha-2 Acetyl-CoA carboxylase kinase ACACA kinase Hydroxymethylglutaryl-CoA reductase kinase HMGCR kinase
External Links
UniProt	P54646
EMBL	U06454 AL035705 BC069680 BC069740 BC069823
CCDS	CCDS605.1
PIR	S51025
RefSeq	NP_006243.2
UniGene	Hs.437039
PDB	2H6D 2LTU 2YZA 3AQV 4CFE 4CFF
PDBsum	2H6D 2LTU 2YZA 3AQV 4CFE 4CFF
ProteinModelPortal	P54646
SMR	P54646
BioGrid	111550
DIP	DIP-39796N
IntAct	P54646
MINT	MINT-2804161
STRING	9606.ENSP00000360290
BindingDB	P54646
ChEMBL	CHEMBL2116
DrugBank	DB00945
GuidetoPHARMACOLOGY	1542
PhosphoSite	P54646
DMDM	20178276
MaxQB	P54646
PaxDb	P54646
PRIDE	P54646
DNASU	5563
Ensembl	ENST00000371244
GeneID	5563
KEGG	hsa:5563
UCSC	uc001cyk.4
CTD	5563
GeneCards	GC01P057027
HGNC	HGNC:9377
HPA	CAB013043
MIM	600497
neXtProt	NX_P54646
PharmGKB	PA33745
eggNOG	COG0515
GeneTree	ENSGT00760000118892
HOGENOM	HOG000233016
HOVERGEN	HBG050432
KO	K07198
OMA	TMHIPPG
OrthoDB	EOG7RRF6K
PhylomeDB	P54646
TreeFam	TF314032
BRENDA	2.7.11.1
Reactome	REACT_11082 REACT_147867 REACT_1988 REACT_200686 REACT_21285 REACT_21393
SignaLink	P54646
ChiTaRS	PRKAA2
EvolutionaryTrace	P54646
GeneWiki	PRKAA2
GenomeRNAi	5563
NextBio	21552
PRO	PR:P54646
Proteomes	UP000005640
Bgee	P54646
CleanEx	HS_PRKAA2
Genevestigator	P54646
GO	GO:0005829 GO:0005654 GO:0050405 GO:0047322 GO:0004679 GO:0005524 GO:0003682 GO:0035174 GO:0046872 GO:0004672 GO:0004674 GO:0004712 GO:0006914 GO:0006853 GO:0007050 GO:0044255 GO:0042149 GO:0031669 GO:0006695 GO:0006112 GO:0006633 GO:0055089 GO:0042593 GO:0008286 GO:0008610 GO:0061024 GO:0043066 GO:0032007 GO:0010508 GO:0045821 GO:0006468 GO:0042752 GO:2000505 GO:0042304 GO:0006355 GO:0006950 GO:0048511 GO:0007165 GO:0044281 GO:0006351 GO:0016055
InterPro	IPR028375 IPR011009 IPR028783 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24343:SF82
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF103243 SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004672	protein kinase activity	PMID:21239628^[1]	ECO:0000314			F		Figure 3	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	C	part_of:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	F	occurs_in:(GO:0030424) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0030425) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0043025) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0030424) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)\|occurs_in(GO:0030425) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)\|occurs_in(GO:0043025) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)	Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	P	occurs_in:(GO:0030424) occurs_in:(CL:0002608)\|occurs_in:(GO:0030425) occurs_in:(CL:0002608)\|occurs_in:(GO:0043025) occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	P	occurs_in:(GO:0030424) occurs_in:(CL:0002608)\|occurs_in:(GO:0030425) occurs_in:(CL:0002608)\|occurs_in:(GO:0043025) occurs_in:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	C	exists_during:(GO:0034599)	Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	F	part_of:(GO:0034599) positively_regulates:(GO:0034063) has_input:(UniProtKB:Q13085)\|part_of(GO:0034599) positively_regulates:(GO:0034063) has_input:(UniProtKB:P05198)\|part_of(GO:0034599) regulates:(GO:0034613)	Seeded From UniProt	complete
involved_in	GO:2000758	positive regulation of peptidyl-lysine acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P	part_of:(GO:0034599) has_regulation_target:(UniProtKB:Q71U36)	Seeded From UniProt	complete
involved_in	GO:1904428	negative regulation of tubulin deacetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P	part_of:(GO:0034599) has_regulation_target:(UniProtKB:Q9UBN7)	Seeded From UniProt	complete
involved_in	GO:1903829	positive regulation of cellular protein localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P	part_of:(GO:0034599) has_regulation_target:(UniProtKB:Q13464)	Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P	part_of:(GO:0034599)	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P	positively_regulates:(GO:0034063)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P	part_of:(GO:0034599) positively_regulates:(GO:0034063) regulates_expression_of:(ENSEMBL:ENSG00000114867)\|part_of(GO:0034599) positively_regulates:(GO:0034063) regulates_expression_of:(ENSEMBL:ENSG00000151247)\|part_of(GO:0034599) regulates_expression_of:(ENSEMBL:ENSG00000094631)	Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	P		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	P		Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q09137	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	F		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P		Seeded From UniProt	complete
involved_in	GO:0031669	cellular response to nutrient levels	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P		Seeded From UniProt	complete
involved_in	GO:0008610	lipid biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	P		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:18439900^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BRK8	F		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336173 MGI:MGI:2145955 PANTHER:PTN001217363	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:2445031 PANTHER:PTN000678822 UniProtKB:P57059 UniProtKB:Q9H0K1 UniProtKB:Q9IA88	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336173 MGI:MGI:2145955 PANTHER:PTN001217363	P		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001217363 RGD:3387 RGD:620893	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:1347352 MGI:MGI:1351488 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:3037705 PANTHER:PTN000678822 RGD:1359167 RGD:3387 RGD:620545 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 TAIR:locus:2094672 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q13131 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1347559 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC32C12.03c PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:3387 RGD:620893 SGD:S000000601 SGD:S000000931 SGD:S000001124 SGD:S000001651 SGD:S000002885 SGD:S000003820 SGD:S000005127 SGD:S000006062 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q57YE4 UniProtKB:Q7XQP4 UniProtKB:Q8I3C7 UniProtKB:Q8IWQ3 UniProtKB:Q8TDC3 UniProtKB:Q940H6 UniProtKB:Q9IA88 WB:WBGene00002210 WB:WBGene00003919 WB:WBGene00020142 WB:WBGene00021012	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC19C2.05 PomBase:SPCC74.03c RGD:69407 RGD:69653 SGD:S000001124 SGD:S000002885 SGD:S000003820 SGD:S000005947 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2159597 TAIR:locus:2160559 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P43291 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q5N942 UniProtKB:Q7XQP4 UniProtKB:Q8TDC3 UniProtKB:Q940H6 WB:WBGene00002210	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025625 MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1336173 MGI:MGI:1347559 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:2685946 PANTHER:PTN000678822 PomBase:SPAC57A10.02 PomBase:SPAC644.06c PomBase:SPBC19C2.05 PomBase:SPBC4F6.06 PomBase:SPCC1020.10 PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:1359167 RGD:1563268 RGD:1566256 RGD:3387 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 SGD:S000005759 TAIR:locus:2009812 TAIR:locus:2094672 TAIR:locus:2102132 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q14680 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q96PF2 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2 UniProtKB:Q9STV4 WB:WBGene00003919	F		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	PMID:22797923^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035404	histone-serine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035174	P		Seeded From UniProt	complete
involved_in	GO:0035404	histone-serine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0035174	P		Seeded From UniProt	complete
involved_in	GO:2000758	positive regulation of peptidyl-lysine acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:1904428	negative regulation of tubulin deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:1903829	positive regulation of cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0071380	cellular response to prostaglandin E stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0062028	regulation of stress granule assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	C		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	F		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0031669	cellular response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	C		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0014850	response to muscle activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	C		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0008610	lipid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	C		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BRK8 ensembl:ENSMUSP00000030243	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039148	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0047322	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.31	F		Seeded From UniProt	complete
enables	GO:0050405	[acetyl-CoA carboxylase] kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.27	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21768291^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:25126726^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:7959015^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:7959015^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:7959015^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042304	regulation of fatty acid biosynthetic process	Reactome:R-HSA-163680	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	Reactome:R-HSA-5673768	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	Reactome:R-HSA-1632852	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	Reactome:R-HSA-380972	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006853	carnitine shuttle	Reactome:R-HSA-200425	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5679239 Reactome:R-HSA-5679205 Reactome:R-HSA-5675868 Reactome:R-HSA-5673768 Reactome:R-HSA-5672011 Reactome:R-HSA-5672008 Reactome:R-HSA-5665868 Reactome:R-HSA-5631941 Reactome:R-HSA-447074 Reactome:R-HSA-380949 Reactome:R-HSA-380930 Reactome:R-HSA-380927 Reactome:R-HSA-200423 Reactome:R-HSA-200421 Reactome:R-HSA-1632857	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6805470 Reactome:R-HSA-163664	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0152	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006694	steroid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0752	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016126	sterol biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0756	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gaskin, FS et al. (2011) Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions. Am. J. Physiol. Heart Circ. Physiol. 300 H1352-60 PubMed GONUTS page
↑ Gwinn, DM et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 214-26 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page
↑ Ju, TC et al. (2011) Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. J. Cell Biol. 194 209-27 PubMed GONUTS page
↑ Dunlop, EA et al. (2014) FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy 10 1749-60 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Aguan, K et al. (1994) Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals. Gene 149 345-50 PubMed GONUTS page

[PMID:21239628-1] Gaskin, FS et al. (2011) Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions. Am. J. Physiol. Heart Circ. Physiol. 300 H1352-60 PubMed GONUTS page

[PMID:18439900-2] Gwinn, DM et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 214-26 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22797923-4] Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page

[PMID:21768291-5] Ju, TC et al. (2011) Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. J. Cell Biol. 194 209-27 PubMed GONUTS page

[PMID:25126726-6] Dunlop, EA et al. (2014) FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy 10 1749-60 PubMed GONUTS page

[PMID:7959015-7] 7.0 ^7.1 ^7.2 Aguan, K et al. (1994) Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals. Gene 149 345-50 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

HUMAN:AAPK2

Contents

Annotations

Notes

References

(

a

c

d

e

f

g

h

i

k

l

m

n

o

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools