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HUMAN:AAKB2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PRKAB2
Protein Name(s) 5'-AMP-activated protein kinase subunit beta-2

AMPK subunit beta-2

External Links
UniProt O43741
EMBL AJ224538
AF504543
AF504538
AF504539
AF504540
AF504541
AF504542
AK292820
AK294863
AK316005
AL356378
CH471223
BC053610
CCDS CCDS925.1
RefSeq NP_005390.1
UniGene Hs.50732
PDB 2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2YA3
4CFH
4EAI
4EAJ
PDBsum 2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2YA3
4CFH
4EAI
4EAJ
ProteinModelPortal O43741
SMR O43741
BioGrid 111552
DIP DIP-39763N
IntAct O43741
STRING 9606.ENSP00000254101
ChEMBL CHEMBL3038453
DrugBank DB00945
DB00131
CAZy CBM48
PhosphoSite O43741
MaxQB O43741
PaxDb O43741
PeptideAtlas O43741
PRIDE O43741
DNASU 5565
Ensembl ENST00000254101
GeneID 5565
KEGG hsa:5565
UCSC uc001epe.3
uc010ozm.2
CTD 5565
GeneCards GC01M146627
HGNC HGNC:9379
HPA HPA044342
MIM 602741
neXtProt NX_O43741
PharmGKB PA33747
eggNOG NOG238368
GeneTree ENSGT00390000001416
HOGENOM HOG000230597
HOVERGEN HBG050430
KO K07199
OMA ESKYITV
PhylomeDB O43741
TreeFam TF313827
Reactome REACT_11082
REACT_147867
REACT_1988
REACT_200686
REACT_21285
REACT_21393
SignaLink O43741
ChiTaRS PRKAB2
EvolutionaryTrace O43741
GeneWiki PRKAB2
GenomeRNAi 5565
NextBio 21560
PRO PR:O43741
Proteomes UP000005640
Bgee O43741
CleanEx HS_PRKAB2
Genevestigator O43741
GO GO:0031588
GO:0005829
GO:0005654
GO:0042802
GO:0006853
GO:0007050
GO:0044255
GO:0006112
GO:0006633
GO:0008286
GO:0061024
GO:0006468
GO:0042304
GO:0007165
GO:0044281
InterPro IPR030081
IPR006828
IPR014756
PANTHER PTHR10343:SF43
Pfam PF04739
SMART SM01010
SUPFAM SSF81296

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004679

regulation of gene expression, epigenetic

PMID:19639604[1]

ECO:0000314

P

Refer to figure 6B on phosphorylation levels

complete
CACAO 5111

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:27411013[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6PAM0

P

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

PMID:17851531[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

PMID:21399626[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0004679

AMP-activated protein kinase activity

PMID:21399626[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
PomBase:SPCC1919.03c
RGD:620905
RGD:71057
SGD:S000000829
SGD:S000003176
UniProtKB:O43741

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
RGD:620905
RGD:71057

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
PomBase:SPCC1919.03c
RGD:620905
SGD:S000000829
SGD:S000003176

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1336167
PANTHER:PTN000038857
PomBase:SPCC1919.03c
SGD:S000000829

C

Seeded From UniProt

complete

contributes_to

GO:0004679

AMP-activated protein kinase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
RGD:71057
SGD:S000000829
SGD:S000003176
UniProtKB:O43741

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21988832[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O43741

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:20562859[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O43741

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004679

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004679

P

Seeded From UniProt

complete

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6PAM0
ensembl:ENSMUSP00000036410

P

Seeded From UniProt

complete

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039160

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9575201[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042304

regulation of fatty acid biosynthetic process

Reactome:R-HSA-163680

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016241

regulation of macroautophagy

Reactome:R-HSA-5673768

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

Reactome:R-HSA-1632852

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

Reactome:R-HSA-380972

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006853

carnitine shuttle

Reactome:R-HSA-200425

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5679239
Reactome:R-HSA-5679205
Reactome:R-HSA-5675868
Reactome:R-HSA-5673768
Reactome:R-HSA-5672011
Reactome:R-HSA-5672008
Reactome:R-HSA-5665868
Reactome:R-HSA-5631941
Reactome:R-HSA-447074
Reactome:R-HSA-380949
Reactome:R-HSA-380930
Reactome:R-HSA-380927
Reactome:R-HSA-200423
Reactome:R-HSA-200421
Reactome:R-HSA-1632857

ECO:0000304

author statement supported by traceable reference used in manual assertion















C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6805470
Reactome:R-HSA-163664

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275

P

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Tong, JF et al. (2009) AMP-activated protein kinase enhances the expression of muscle-specific ubiquitin ligases despite its activation of IGF-1/Akt signaling in C2C12 myotubes. J. Cell. Biochem. 108 458-68 PubMed GONUTS page
  2. ↑ Mottillo, EP et al. (2016) Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Cell Metab. 24 118-29 PubMed GONUTS page
  3. ↑ Xiao, B et al. (2007) Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature 449 496-500 PubMed GONUTS page
  4. ↑ 4.0 4.1 Xiao, B et al. (2011) Structure of mammalian AMPK and its regulation by ADP. Nature 472 230-3 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page
  7. ↑ Behrends, C et al. (2010) Network organization of the human autophagy system. Nature 466 68-76 PubMed GONUTS page
  8. ↑ Thornton, C et al. (1998) Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. J. Biol. Chem. 273 12443-50 PubMed GONUTS page
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