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HUMAN:A2MG
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | A2M (synonyms: CPAMD5) | |
| Protein Name(s) | Alpha-2-macroglobulin
Alpha-2-M C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 | |
| External Links | ||
| UniProt | P01023 | |
| EMBL | M11313 AY591530 AB209614 CR749334 AC007436 BC026246 BC040071 Z11711 X68728 X68729 M36501 AF109189 | |
| CCDS | CCDS44827.1 | |
| PIR | A94033 | |
| RefSeq | NP_000005.2 | |
| UniGene | Hs.212838 | |
| PDB | 1BV8 2P9R 4ACQ | |
| PDBsum | 1BV8 2P9R 4ACQ | |
| ProteinModelPortal | P01023 | |
| SMR | P01023 | |
| BioGrid | 106524 | |
| DIP | DIP-1118N | |
| IntAct | P01023 | |
| MINT | MINT-122288 | |
| STRING | 9606.ENSP00000323929 | |
| DrugBank | DB00626 DB00102 DB08888 | |
| MEROPS | I39.001 | |
| PhosphoSite | P01023 | |
| DMDM | 308153640 | |
| DOSAC-COBS-2DPAGE | P01023 | |
| SWISS-2DPAGE | P01023 | |
| MaxQB | P01023 | |
| PaxDb | P01023 | |
| PeptideAtlas | P01023 | |
| PRIDE | P01023 | |
| Ensembl | ENST00000318602 | |
| GeneID | 2 | |
| KEGG | hsa:2 | |
| UCSC | uc001qvk.1 | |
| CTD | 2 | |
| GeneCards | GC12M009220 | |
| H-InvDB | HIX0026392 | |
| HGNC | HGNC:7 | |
| HPA | CAB017621 HPA002265 | |
| MIM | 103950 | |
| neXtProt | NX_P01023 | |
| PharmGKB | PA24357 | |
| eggNOG | COG2373 | |
| GeneTree | ENSGT00760000118982 | |
| HOVERGEN | HBG000039 | |
| InParanoid | P01023 | |
| KO | K03910 | |
| OMA | QTVQAHY | |
| OrthoDB | EOG7DJSKB | |
| PhylomeDB | P01023 | |
| TreeFam | TF313285 | |
| Reactome | REACT_11051 REACT_118572 REACT_13621 REACT_326 | |
| ChiTaRS | A2M | |
| EvolutionaryTrace | P01023 | |
| GenomeRNAi | 2 | |
| NextBio | 5 | |
| PRO | PR:P01023 | |
| Proteomes | UP000005640 | |
| Bgee | P01023 | |
| CleanEx | HS_A2M | |
| ExpressionAtlas | P01023 | |
| Genevestigator | P01023 | |
| GO | GO:0072562 GO:0005829 GO:0005576 GO:0070062 GO:0031093 GO:0048306 GO:0019899 GO:0019838 GO:0019966 GO:0019959 GO:0002020 GO:0005102 GO:0004867 GO:0043120 GO:0007596 GO:0007597 GO:0022617 GO:0030198 GO:0001869 GO:0010951 GO:0030168 GO:0002576 GO:0051056 GO:0007264 GO:0048863 | |
| Gene3D | 1.50.10.20 2.60.40.690 | |
| InterPro | IPR009048 IPR011626 IPR002890 IPR011625 IPR014756 IPR001599 IPR019742 IPR019565 IPR008930 IPR010916 | |
| Pfam | PF00207 PF07678 PF01835 PF07703 PF07677 PF10569 | |
| SUPFAM | SSF48239 SSF49410 SSF81296 | |
| PROSITE | PS00477 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
colocalizes_with |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0002570) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0003688)|part_of:(UBERON:0001911) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002107) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001155) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002020 |
protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002020 |
protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0072562 |
blood microparticle |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000639) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
inhibited_by:(CHEBI:60888) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
inhibited_by:(CHEBI:60888) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
inhibited_by:(CHEBI:60888) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
inhibited_by:(CHEBI:60888) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
inhibited_by:(CHEBI:60888) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0002367) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043120 |
tumor necrosis factor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019966 |
interleukin-1 binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019959 |
interleukin-8 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019838 |
growth factor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001869 |
negative regulation of complement activation, lectin pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004866 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004867 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004867 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048863 |
stem cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6GQT1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004866 |
endopeptidase inhibitor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
Reactome:R-HSA-194840 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031093 |
platelet alpha granule lumen |
Reactome:R-HSA-481007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022617 |
extracellular matrix disassembly |
Reactome:R-HSA-1474228 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007597 |
blood coagulation, intrinsic pathway |
Reactome:R-HSA-140837 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-194922 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-481007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0002576 |
platelet degranulation |
Reactome:R-HSA-114608 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010466 |
negative regulation of peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030414 |
peptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
- ↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
- ↑ 3.0 3.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 5.0 5.1 Luan, Y et al. (2008) Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthr. Cartil. 16 1413-20 PubMed GONUTS page
- ↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
- ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Ling, TY et al. (2004) Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. J. Biol. Chem. 279 38736-48 PubMed GONUTS page
- ↑ Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page
- ↑ 10.0 10.1 Webb, DJ & Gonias, SL (1998) A modified human alpha 2-macroglobulin derivative that binds tumor necrosis factor-alpha and interleukin-1 beta with high affinity in vitro and reverses lipopolysaccharide toxicity in vivo in mice. Lab. Invest. 78 939-48 PubMed GONUTS page
- ↑ Kurdowska, A et al. (2000) Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages. Cytokine 12 1046-53 PubMed GONUTS page
- ↑ Krimbou, L et al. (2001) Interaction of lecithin:cholesterol acyltransferase (LCAT).alpha 2-macroglobulin complex with low density lipoprotein receptor-related protein (LRP). Evidence for an alpha 2-macroglobulin/LRP receptor-mediated system participating in LCAT clearance. J. Biol. Chem. 276 33241-8 PubMed GONUTS page
- ↑ Gavish, H et al. (1997) Human alpha 2-macroglobulin is an osteogenic growth peptide-binding protein. Biochemistry 36 14883-8 PubMed GONUTS page
- ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
- ↑ 15.0 15.1 Ambrus, G et al. (2003) Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments. J. Immunol. 170 1374-82 PubMed GONUTS page
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