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HUMAN:3MG
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MPG (synonyms: AAG, ANPG, MID1) | |
| Protein Name(s) | DNA-3-methyladenine glycosylase
3-alkyladenine DNA glycosylase 3-methyladenine DNA glycosidase ADPG N-methylpurine-DNA glycosylase | |
| External Links | ||
| UniProt | P29372 | |
| EMBL | M74905 L10752 AY258284 AY305873 AF499437 AE006462 Z69720 Z69720 CH471112 BC014991 S51033 X56528 M71215 M99626 | |
| CCDS | CCDS32345.1 CCDS32346.1 CCDS42087.1 | |
| PIR | A40798 A41230 A47471 JN0062 | |
| RefSeq | NP_001015052.1 NP_001015054.1 NP_002425.2 | |
| UniGene | Hs.459596 | |
| PDB | 1BNK 1EWN 1F4R 1F6O 3QI5 3UBY | |
| PDBsum | 1BNK 1EWN 1F4R 1F6O 3QI5 3UBY | |
| ProteinModelPortal | P29372 | |
| SMR | P29372 | |
| BioGrid | 110490 | |
| IntAct | P29372 | |
| MINT | MINT-135511 | |
| STRING | 9606.ENSP00000219431 | |
| PhosphoSite | P29372 | |
| MaxQB | P29372 | |
| PaxDb | P29372 | |
| PRIDE | P29372 | |
| DNASU | 4350 | |
| Ensembl | ENST00000219431 ENST00000356432 ENST00000397817 | |
| GeneID | 4350 | |
| KEGG | hsa:4350 | |
| UCSC | uc002cfm.4 uc002cfo.4 | |
| CTD | 4350 | |
| GeneCards | GC16P000127 | |
| HGNC | HGNC:7211 | |
| HPA | HPA006531 | |
| MIM | 156565 | |
| neXtProt | NX_P29372 | |
| PharmGKB | PA30917 | |
| eggNOG | COG2094 | |
| GeneTree | ENSGT00390000009825 | |
| HOGENOM | HOG000224224 | |
| HOVERGEN | HBG000019 | |
| InParanoid | P29372 | |
| KO | K03652 | |
| OMA | THYPLRF | |
| PhylomeDB | P29372 | |
| TreeFam | TF331768 | |
| Reactome | REACT_1064 REACT_1729 REACT_2176 | |
| ChiTaRS | MPG | |
| EvolutionaryTrace | P29372 | |
| GeneWiki | MPG_(gene) | |
| GenomeRNAi | 4350 | |
| NextBio | 17110 | |
| PRO | PR:P29372 | |
| Proteomes | UP000005640 | |
| Bgee | P29372 | |
| CleanEx | HS_MID1 HS_MPG | |
| ExpressionAtlas | P29372 | |
| Genevestigator | P29372 | |
| GO | GO:0042645 GO:0005654 GO:0003905 GO:0003684 GO:0008725 GO:0052822 GO:0052821 GO:0043916 GO:0006284 GO:0006285 GO:0045007 GO:0006307 GO:0006281 | |
| Gene3D | 3.10.300.10 | |
| HAMAP | MF_00527 | |
| InterPro | IPR011034 IPR003180 | |
| PANTHER | PTHR10429 | |
| Pfam | PF02245 | |
| SUPFAM | SSF50486 | |
| TIGRFAMs | TIGR00567 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006284 |
base-excision repair |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97073 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003905 |
alkylbase DNA N-glycosylase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97073 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006284 |
base-excision repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04841 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003905 |
alkylbase DNA N-glycosylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q04841 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003905 |
alkylbase DNA N-glycosylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006284 |
base-excision repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003905 |
alkylbase DNA N-glycosylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008725 |
DNA-3-methyladenine glycosylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052822 |
DNA-3-methylguanine glycosylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052821 |
DNA-7-methyladenine glycosylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043916 |
DNA-7-methylguanine glycosylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006307 |
DNA dealkylation involved in DNA repair |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006284 |
base-excision repair |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
PMID:10854423[3] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0003684 |
damaged DNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045007 |
depurination |
Reactome:R-HSA-110331 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
enables |
GO:0019104 |
DNA N-glycosylase activity |
Reactome:R-HSA-110251 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042645 |
mitochondrial nucleoid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ O'Connor, TR & Laval, J (1991) Human cDNA expressing a functional DNA glycosylase excising 3-methyladenine and 7-methylguanine. Biochem. Biophys. Res. Commun. 176 1170-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Miao, F et al. (2000) 3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins. J. Biol. Chem. 275 28433-8 PubMed GONUTS page
d
- GO:0003684 ! damaged DNA binding
- GO:0045007 ! depurination
- GO:0008725 ! DNA-3-methyladenine glycosylase activity
- GO:0052822 ! DNA-3-methylguanine glycosylase activity
- GO:0043916 ! DNA-7-methylguanine glycosylase activity
- GO:0052821 ! DNA-7-methyladenine glycosylase activity
- GO:0006307 ! DNA alkylation repair
- GO:0003677 ! DNA binding
- GO:0006974 ! DNA damage response
- GO:0019104 ! DNA N-glycosylase activity
- GO:0006281 ! DNA repair
p
