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HUMAN:1C17

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) HLA-C (synonyms: D6S204, HLA-JY3, HLAC)
Protein Name(s) HLA class I histocompatibility antigen, Cw-17 alpha chain

MHC class I antigen Cw*17

External Links
UniProt Q95604
EMBL U62824
X98742
Y10520
AJ420252
D64149
Y18537
Y18538
Y18539
Y18540
Y18541
U06835
PIR A59028
UniGene Hs.656020
Hs.743218
Hs.77961
ProteinModelPortal Q95604
SMR Q95604
IntAct Q95604
DMDM 34395506
MaxQB Q95604
PaxDb Q95604
PRIDE Q95604
Ensembl ENST00000400341
ENST00000400394
GeneCards GC06M031236
GC06Mn31226
GC06Mo31229
HGNC HGNC:4933
MIM 142840
neXtProt NX_Q95604
eggNOG NOG42056
HOVERGEN HBG016709
InParanoid Q95604
PhylomeDB Q95604
Reactome REACT_111168
REACT_111178
REACT_11152
REACT_25078
REACT_25162
REACT_75795
ChiTaRS HLA-C
Proteomes UP000005640
CleanEx HS_HLA-C
Genevestigator Q95604
GO GO:0009986
GO:0031901
GO:0005783
GO:0012507
GO:0005794
GO:0000139
GO:0071556
GO:0042612
GO:0030670
GO:0005886
GO:0042605
GO:0042590
GO:0002479
GO:0002480
GO:0002474
GO:0019221
GO:0060333
GO:0001916
GO:0050776
GO:0060337
GO:0016032
Gene3D 2.60.40.10
3.30.500.10
InterPro IPR007110
IPR013783
IPR003006
IPR003597
IPR011161
IPR011162
IPR027648
IPR001039
IPR010579
Pfam PF07654
PF00129
PF06623
PRINTS PR01638
SMART SM00407
SUPFAM SSF54452
PROSITE PS50835
PS00290

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0042612

MHC class I protein complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30499

C

Seeded From UniProt

complete

enables

GO:0042605

peptide antigen binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P30499

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04222

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q29963

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q29963

C

Seeded From UniProt

complete

enables

GO:0042605

peptide antigen binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95904
MGI:MGI:95915
MGI:MGI:95938
PANTHER:PTN000422452
UniProtKB:P01891
UniProtKB:P13747
UniProtKB:Q31612
UniProtKB:Q95604

F

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107674
MGI:MGI:109431
MGI:MGI:109432
MGI:MGI:1861032
MGI:MGI:1925027
MGI:MGI:2179988
MGI:MGI:2179989
MGI:MGI:95896
MGI:MGI:95904
MGI:MGI:95915
MGI:MGI:95938
PANTHER:PTN002314307
UniProtKB:Q30201

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002314307
UniProtKB:P01891
UniProtKB:Q31612

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95896
PANTHER:PTN002314307
UniProtKB:Q95460
UniProtKB:Q9BZM6

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95929
PANTHER:PTN002314307
UniProtKB:P25311
UniProtKB:Q29983
UniProtKB:Q30201
UniProtKB:Q9BZM5

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000422452
UniProtKB:P01891
UniProtKB:P13747
UniProtKB:P17693
UniProtKB:Q31612

F

Seeded From UniProt

complete

involved_in

GO:0002486

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002497567
UniProtKB:P01891
UniProtKB:Q31612
UniProtKB:Q95604

P

Seeded From UniProt

complete

involved_in

GO:0002476

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95915
MGI:MGI:95938
PANTHER:PTN002497567
UniProtKB:P13747

P

Seeded From UniProt

complete

involved_in

GO:0001916

positive regulation of T cell mediated cytotoxicity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95896
MGI:MGI:95904
MGI:MGI:95915
MGI:MGI:95938
MGI:MGI:95957
PANTHER:PTN002497567
RGD:1595924
UniProtKB:P01891
UniProtKB:P13747
UniProtKB:Q31612

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010579

P

Seeded From UniProt

complete

involved_in

GO:0019882

antigen processing and presentation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010579

P

Seeded From UniProt

complete

part_of

GO:0071556

integral component of lumenal side of endoplasmic reticulum membrane

Reactome:R-HSA-983426
Reactome:R-HSA-983425
Reactome:R-HSA-983424
Reactome:R-HSA-983161
Reactome:R-HSA-983146
Reactome:R-HSA-983145
Reactome:R-HSA-983142
Reactome:R-HSA-983138
Reactome:R-HSA-8951499
Reactome:R-HSA-1031716
Reactome:R-HSA-1015702

ECO:0000304

author statement supported by traceable reference used in manual assertion











C

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

Reactome:R-HSA-909733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060333

interferon-gamma-mediated signaling pathway

Reactome:R-HSA-877300

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0055038

recycling endosome membrane

Reactome:R-HSA-8863973

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050776

regulation of immune response

Reactome:R-HSA-198933

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031901

early endosome membrane

Reactome:R-HSA-1236964
Reactome:R-HSA-1236954
Reactome:R-HSA-1236943

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0030670

phagocytic vesicle membrane

Reactome:R-HSA-8863973
Reactome:R-HSA-1236965

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0012507

ER to Golgi transport vesicle membrane

Reactome:R-HSA-983424
Reactome:R-HSA-983422
Reactome:R-HSA-983421

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-983427
Reactome:R-HSA-198955
Reactome:R-HSA-1236965
Reactome:R-HSA-1236964

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0002480

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

Reactome:R-HSA-1236977

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002479

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Reactome:R-HSA-1236974

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002474

antigen processing and presentation of peptide antigen via MHC class I

Reactome:R-HSA-983169

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

Reactome:R-HSA-983427
Reactome:R-HSA-983421

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0042612

MHC class I protein complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0490

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0002474

antigen processing and presentation of peptide antigen via MHC class I

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0490

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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