HORSE:F6R7B4

Species (Taxon ID)	Equus caballus (Horse). (9796)
Gene Name(s)	MMP8 (ECO:0000313 with VGNC:VGNC:20236)
Protein Name(s)	Matrix metalloproteinase (ECO:0000256 with RuleBase:RU364080)
External Links
UniProt	F6R7B4
ProteinModelPortal	F6R7B4
STRING	9796.ENSECAP00000018911
MEROPS	M10.002
PaxDb	F6R7B4
Ensembl	ENSECAT00000022856
VGNC	VGNC:20236
eggNOG	KOG1565 ENOG410XQ5D
GeneTree	ENSGT00760000118870
InParanoid	F6R7B4
OMA	NYTPQLS
OrthoDB	EOG091G03DP
TreeFam	TF315428
Proteomes	UP000002281
Bgee	ENSECAG00000021476
GO	GO:0031012 GO:0005615 GO:0004222 GO:0004252 GO:0008270 GO:0035987
CDD	cd00094 cd04278
Gene3D	1.10.101.10 2.110.10.10 3.40.390.10
InterPro	IPR000585 IPR036375 IPR018487 IPR018486 IPR033739 IPR024079 IPR028709 IPR001818 IPR021190 IPR006026 IPR002477 IPR036365 IPR036366
PANTHER	PTHR10201:SF137
Pfam	PF00045 PF00413 PF01471
PIRSF	PIRSF001191
PRINTS	PR00138
SMART	SM00120 SM00235
SUPFAM	SSF47090 SSF50923
PROSITE	PS00024 PS51642

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0030574	collagen catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101900 MGI:MGI:1276107 MGI:MGI:1340026 MGI:MGI:97008 MGI:MGI:97009 MGI:MGI:97011 PANTHER:PTN001303987 RGD:621316 RGD:621320 UniProtKB:P45452	P	Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033438 FB:FBgn0035049 MGI:MGI:1340026 MGI:MGI:1353466 MGI:MGI:97008 MGI:MGI:97011 PANTHER:PTN001303987 UniProtKB:P45452 WB:WBGene00006987 ZFIN:ZDB-GENE-040426-2132	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97005 MGI:MGI:97009 PANTHER:PTN000810753 RGD:3100 RGD:620196 RGD:621316 RGD:621317 RGD:621320 RGD:631408 UniProtKB:B5DFD5 UniProtKB:P02790 UniProtKB:P08253 UniProtKB:P14780 UniProtKB:P22894 UniProtKB:P39900 UniProtKB:P50281 UniProtKB:Q90611	C	Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033438 MGI:MGI:101900 MGI:MGI:1340026 MGI:MGI:1341867 MGI:MGI:97009 MGI:MGI:97011 PANTHER:PTN001303987 RGD:620196 TAIR:locus:2020548 TAIR:locus:2025891 TAIR:locus:2032467 TAIR:locus:2055605 TAIR:locus:2130928 UniProtKB:O60882 UniProtKB:O75900 UniProtKB:P03956 UniProtKB:P14780 UniProtKB:P39900 UniProtKB:P45452 UniProtKB:P51512 UniProtKB:Q90611 UniProtKB:Q99542	F	Seeded From UniProt	complete
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:1903980	positive regulation of microglial cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:0150078	positive regulation of neuroinflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:0032693	negative regulation of interleukin-10 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70138 ensembl:ENSMUSP00000018765	P	Seeded From UniProt	complete
involved_in	GO:0035987	endodermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22894 ensembl:ENSP00000236826	P	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22894 ensembl:ENSP00000236826	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22894 ensembl:ENSP00000236826	C	Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22894 ensembl:ENSP00000236826	F	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22894 ensembl:ENSP00000236826	F	Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR021190 InterPro:IPR028709	F	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR006026 InterPro:IPR021190 InterPro:IPR028709	P	Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006026 InterPro:IPR024079 InterPro:IPR033739	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR006026 InterPro:IPR021190 InterPro:IPR028709 InterPro:IPR033739	F	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR021190	C	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F	Seeded From UniProt	complete
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Notes

Scavenger Hunt Item: #29

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HORSE:F6R7B4

Contents

Annotations

Notes

References

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