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EMENI:NIRA

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Species (Taxon ID) Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL194 / M139) (Aspergillus nidulans). (227321)
Gene Name(s) nirA
Protein Name(s) Nitrogen assimilation transcription factor nirA
External Links
UniProt P28348
EMBL M68900
AACD01000004
BN001308
PIR A41697
RefSeq XP_657702.1
ProteinModelPortal P28348
STRING 162425.CADANIAP00002651
EnsemblFungi [example_ID CADANIAT00002651]
GeneID 2875872
KEGG ani:AN0098.2
eggNOG NOG75868
HOGENOM HOG000176191
InParanoid P28348
OMA SPRRICT
OrthoDB EOG7NCVC1
Proteomes UP000000560
GO GO:0005634
GO:0003677
GO:0043565
GO:0000981
GO:0003700
GO:0044212
GO:0008270
GO:0006338
GO:0042128
GO:0016584
GO:0006808
GO:0006355
GO:0005982
Gene3D 4.10.240.10
InterPro IPR007219
IPR001138
Pfam PF04082
PF00172
SMART SM00906
SM00066
SUPFAM SSF57701
PROSITE PS00463
PS50048

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0003700

sequence-specific DNA binding transcription factor activity

PMID:1922075[1]

ECO:0000314

F

Figure 6,7. These figures show that the NIRA protein binds to the cis-acting sites of niaD and niiA.

complete
CACAO 2413

enables

GO:0003700

DNA-binding transcription factor activity

PMID:1922075[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:9488449[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:7565720[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:11972792[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016584

nucleosome positioning

PMID:16390440[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006808

regulation of nitrogen utilization

PMID:347305[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006808

regulation of nitrogen utilization

PMID:11972792[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006338

chromatin remodeling

PMID:18673441[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16390440[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:1922075[1]

ECO:0000247

sequence alignment evidence used in manual assertion

SGD:S000006169

F

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0000981

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001138
InterPro:IPR036864

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007219

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001138
InterPro:IPR007219
InterPro:IPR036864

C

Seeded From UniProt

complete

involved_in

GO:0006351

transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007219

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001138
InterPro:IPR036864

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001138
InterPro:IPR007219
InterPro:IPR036864

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0042128

nitrate assimilation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0534

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Burger, G et al. (1991) nirA, the pathway-specific regulatory gene of nitrate assimilation in Aspergillus nidulans, encodes a putative GAL4-type zinc finger protein and contains four introns in highly conserved regions. Mol. Cell. Biol. 11 5746-55 PubMed GONUTS page
  2. Strauss, J et al. (1998) The regulator of nitrate assimilation in ascomycetes is a dimer which binds a nonrepeated, asymmetrical sequence. Mol. Cell. Biol. 18 1339-48 PubMed GONUTS page
  3. Punt, PJ et al. (1995) The intergenic region between the divergently transcribed niiA and niaD genes of Aspergillus nidulans contains multiple NirA binding sites which act bidirectionally. Mol. Cell. Biol. 15 5688-99 PubMed GONUTS page
  4. 4.0 4.1 Narendja, F et al. (2002) Nitrate and the GATA factor AreA are necessary for in vivo binding of NirA, the pathway-specific transcriptional activator of Aspergillus nidulans. Mol. Microbiol. 44 573-83 PubMed GONUTS page
  5. 5.0 5.1 Berger, H et al. (2006) The GATA factor AreA regulates localization and in vivo binding site occupancy of the nitrate activator NirA. Mol. Microbiol. 59 433-46 PubMed GONUTS page
  6. Rand, KN & Arst, HN Jr (1978) Mutations in nirA gene of Aspergillus nidulans and nitrogen metabolism. Nature 272 732-4 PubMed GONUTS page
  7. Berger, H et al. (2008) Dissecting individual steps of nitrogen transcription factor cooperation in the Aspergillus nidulans nitrate cluster. Mol. Microbiol. 69 1385-98 PubMed GONUTS page