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ECOLI:SYD

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) aspS (ECO:0000255 with HAMAP-Rule:MF_00044) (synonyms: tls)
Protein Name(s) Aspartate--tRNA ligase (ECO:0000255 with HAMAP-Rule:MF_00044)

Aspartyl-tRNA synthetase (ECO:0000255 with HAMAP-Rule:MF_00044) AspRS (ECO:0000255 with HAMAP-Rule:MF_00044)

External Links
UniProt P21889
EMBL X53863
U00096
AP009048
X53984
D10165
PIR JT0942
RefSeq NP_416380.1
YP_490128.1
PDB 1C0A
1EQR
1IL2
PDBsum 1C0A
1EQR
1IL2
ProteinModelPortal P21889
SMR P21889
DIP DIP-9182N
IntAct P21889
MINT MINT-1249167
STRING 511145.b1866
BindingDB P21889
SWISS-2DPAGE P21889
PaxDb P21889
PRIDE P21889
EnsemblBacteria AAC74936
BAA15677
GeneID 12930336
946385
KEGG ecj:Y75_p1842
eco:b1866
PATRIC 32119055
EchoBASE EB0095
EcoGene EG10097
eggNOG COG0173
HOGENOM HOG000275159
InParanoid P21889
KO K01876
OMA YQLDVEM
OrthoDB EOG68Q0NX
PhylomeDB P21889
BioCyc EcoCyc:ASPS-MONOMER
ECOL316407:JW1855-MONOMER
MetaCyc:ASPS-MONOMER
SABIO-RK P21889
EvolutionaryTrace P21889
PRO PR:P21889
Proteomes UP000000318
UP000000625
Genevestigator P21889
GO GO:0005829
GO:0004815
GO:0005524
GO:0003676
GO:0006422
Gene3D 2.40.50.140
3.30.1360.30
HAMAP MF_00044
InterPro IPR004364
IPR018150
IPR006195
IPR004524
IPR002312
IPR004115
IPR029351
IPR012340
IPR004365
PANTHER PTHR22594
PTHR22594:SF5
Pfam PF02938
PF00152
PF01336
PRINTS PR01042
SUPFAM SSF50249
SSF55261
TIGRFAMs TIGR00459
PROSITE PS50862

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005829

cytosol

PMID:16858726[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006422

aspartyl-tRNA aminoacylation

PMID:9171418[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004815

aspartate-tRNA ligase activity

PMID:9171418[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002312
InterPro:IPR004364

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004365

F

Seeded From UniProt

complete

enables

GO:0004812

aminoacyl-tRNA ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002312
InterPro:IPR004115
InterPro:IPR004364

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002312
InterPro:IPR004115
InterPro:IPR004364
InterPro:IPR004524

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004115

C

Seeded From UniProt

complete

involved_in

GO:0006418

tRNA aminoacylation for protein translation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002312
InterPro:IPR004364

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004524

F

Seeded From UniProt

complete

enables

GO:0004815

aspartate-tRNA ligase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.1.1.12

F

Seeded From UniProt

complete

involved_in

GO:0006422

aspartyl-tRNA aminoacylation

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000334366

P

Seeded From UniProt

complete

enables

GO:0004815

aspartate-tRNA ligase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000334366

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000334366

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000334366

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0004812

aminoacyl-tRNA ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0030

F

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0006412

translation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0648

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed GONUTS page
  2. 2.0 2.1 Martin, F et al. (1997) Characterization of a thermosensitive Escherichia coli aspartyl-tRNA synthetase mutant. J. Bacteriol. 179 3691-6 PubMed GONUTS page
  3. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page