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ECOLI:SSB

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) ssb (synonyms: exrB, lexC)
Protein Name(s) Single-stranded DNA-binding protein (ECO:0000255 with HAMAP-Rule:MF_00984)

SSB (ECO:0000255 with HAMAP-Rule:MF_00984) Helix-destabilizing protein

External Links
UniProt P0AGE0
EMBL J01704
U00006
U00096
AP009048
PIR B65214
RefSeq NP_418483.1
YP_492202.1
PDB 1EQQ
1EYG
1KAW
1QVC
1SRU
3C94
3SXU
3UF7
4MZ9
PDBsum 1EQQ
1EYG
1KAW
1QVC
1SRU
3C94
3SXU
3UF7
4MZ9
ProteinModelPortal P0AGE0
SMR P0AGE0
DIP DIP-35980N
IntAct P0AGE0
MINT MINT-8298796
STRING 511145.b4059
SWISS-2DPAGE P0AGE0
PaxDb P0AGE0
PRIDE P0AGE0
EnsemblBacteria AAC77029
BAE78061
GeneID 12933677
948570
KEGG ecj:Y75_p3946
eco:b4059
PATRIC 32123663
EchoBASE EB0969
EcoGene EG10976
eggNOG COG0629
HOGENOM HOG000106483
InParanoid P0AGE0
KO K03111
OMA QQYNEPP
OrthoDB EOG6M9F32
PhylomeDB P0AGE0
BioCyc EcoCyc:EG10976-MONOMER
ECOL316407:JW4020-MONOMER
EvolutionaryTrace P0AGE0
PRO PR:P0AGE0
Proteomes UP000000318
UP000000625
Genevestigator P0AGE0
GO GO:0003697
GO:0006260
GO:0006298
GO:0000725
GO:0009432
Gene3D 2.40.50.140
HAMAP MF_00984
InterPro IPR012340
IPR000424
IPR011344
PANTHER PTHR10302
Pfam PF00436
PIRSF PIRSF002070
SUPFAM SSF50249
TIGRFAMs TIGR00621
PROSITE PS50935

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0043085

positive regulation of catalytic activity

PMID:18591666[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008047

enzyme activator activity

PMID:18591666[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051096

positive regulation of helicase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000033807
UniProtKB:Q04837

P

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10976
FB:FBgn0010438
PANTHER:PTN000033807
PomBase:SPAC2F3.04c
SGD:S000007222
TAIR:locus:2015353
UniProtKB:P9WGD5
UniProtKB:Q8I415

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:4566449[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:1090613[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:4566449[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:1090613[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000424
InterPro:IPR011344

F

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011344

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000119535

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000119535

P

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000119535

P

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000119535

F

Seeded From UniProt

complete

involved_in

GO:0009432

SOS response

PMID:2087220[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:2087220[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000725

recombinational repair

PMID:2087220[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0233

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Lu, D & Keck, JL (2008) Structural basis of Escherichia coli single-stranded DNA-binding protein stimulation of exonuclease I. Proc. Natl. Acad. Sci. U.S.A. 105 9169-74 PubMed GONUTS page
  2. 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 Sigal, N et al. (1972) A DNA-unwinding protein isolated from Escherichia coli: its interaction with DNA and with DNA polymerases. Proc. Natl. Acad. Sci. U.S.A. 69 3537-41 PubMed GONUTS page
  4. 4.0 4.1 Weiner, JH et al. (1975) The deoxyribonucleic acid unwinding protein of Escherichia coli. Properties and functions in replication. J. Biol. Chem. 250 1972-80 PubMed GONUTS page
  5. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  6. 6.0 6.1 6.2 Meyer, RR & Laine, PS (1990) The single-stranded DNA-binding protein of Escherichia coli. Microbiol. Rev. 54 342-80 PubMed GONUTS page