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ECOLI:MEPA
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | mepA | |
| Protein Name(s) | Penicillin-insensitive murein endopeptidase
D-alanyl-D-alanine-endopeptidase DD-endopeptidase | |
| External Links | ||
| UniProt | P0C0T5 | |
| EMBL | X16909 U00096 AP009048 | |
| PIR | S08345 | |
| RefSeq | NP_416831.1 YP_490570.1 | |
| PDB | 1TZP 1U10 | |
| PDBsum | 1TZP 1U10 | |
| ProteinModelPortal | P0C0T5 | |
| SMR | P0C0T5 | |
| IntAct | P0C0T5 | |
| STRING | 511145.b2328 | |
| MEROPS | M74.001 | |
| PaxDb | P0C0T5 | |
| PRIDE | P0C0T5 | |
| EnsemblBacteria | AAC75388 BAA16184 | |
| GeneID | 12930653 946812 | |
| KEGG | ecj:Y75_p2294 eco:b2328 | |
| PATRIC | 32120029 | |
| EchoBASE | EB0575 | |
| EcoGene | EG10580 | |
| eggNOG | COG3770 | |
| HOGENOM | HOG000276210 | |
| InParanoid | P0C0T5 | |
| KO | K07261 | |
| OMA | VRPWWGH | |
| OrthoDB | EOG6F295X | |
| BioCyc | EcoCyc:EG10580-MONOMER ECOL316407:JW2325-MONOMER MetaCyc:EG10580-MONOMER | |
| EvolutionaryTrace | P0C0T5 | |
| PRO | PR:P0C0T5 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P0C0T5 | |
| GO | GO:0030288 GO:0004175 GO:0046872 GO:0004222 GO:0008233 GO:0004252 GO:0009252 GO:0000270 GO:0042493 | |
| Gene3D | 3.30.1380.10 | |
| HAMAP | MF_01623 | |
| InterPro | IPR009045 IPR005073 | |
| Pfam | PF03411 | |
| PIRSF | PIRSF018455 | |
| SUPFAM | SSF55166 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009252 |
peptidoglycan biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004175 |
endopeptidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004175 |
endopeptidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000270 |
peptidoglycan metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000270 |
peptidoglycan metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000270 |
peptidoglycan metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000270 |
peptidoglycan metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030288 |
outer membrane-bounded periplasmic space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000080056 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000270 |
peptidoglycan metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000080056 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0042597 |
periplasmic space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000080056 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0042597 |
periplasmic space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Smulski, DR et al. (2001) Combined, functional genomic-biochemical approach to intermediary metabolism: interaction of acivicin, a glutamine amidotransferase inhibitor, with Escherichia coli K-12. J. Bacteriol. 183 3353-64 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Engel, H et al. (1992) Enzymatic preparation of 1,6-anhydro-muropeptides by immobilized murein hydrolases from Escherichia coli fused to staphylococcal protein A. Appl. Microbiol. Biotechnol. 37 772-83 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Keck, W et al. (1990) Cloning and characterization of mepA, the structural gene of the penicillin-insensitive murein endopeptidase from Escherichia coli. Mol. Microbiol. 4 209-19 PubMed GONUTS page
- ↑ 4.0 4.1 Iida, K et al. (1983) Mutants of Escherichia coli defective in penicillin-insensitive murein DD-endopeptidase. Mol. Gen. Genet. 189 215-21 PubMed GONUTS page
- ↑ Heidrich, C et al. (2001) Involvement of N-acetylmuramyl-L-alanine amidases in cell separation and antibiotic-induced autolysis of Escherichia coli. Mol. Microbiol. 41 167-78 PubMed GONUTS page
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