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ECOLI:MAZF
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | mazF (synonyms: chpA, chpAK) | |
| Protein Name(s) | Endoribonuclease toxin MazF
Toxin MazF mRNA interferase MazF (ECO:0000303 with PMID:15537630[1]) | |
| External Links | ||
| UniProt | P0AE70 | |
| EMBL | D16450 J04039 U29580 U00096 AP009048 | |
| PIR | B49339 | |
| RefSeq | NP_417262.1 WP_000254738.1 | |
| PDB | 1UB4 3NFC 5CK9 5CKB 5CKD 5CKE 5CKF 5CKH 5CO7 5CQX 5CQY 5CR2 | |
| PDBsum | 1UB4 3NFC 5CK9 5CKB 5CKD 5CKE 5CKF 5CKH 5CO7 5CQX 5CQY 5CR2 | |
| DisProt | DP00299 | |
| ProteinModelPortal | P0AE70 | |
| SMR | P0AE70 | |
| BioGrid | 4262300 | |
| IntAct | P0AE70 | |
| STRING | 316385.ECDH10B_2949 | |
| BindingDB | P0AE70 | |
| ChEMBL | CHEMBL1795096 | |
| PaxDb | P0AE70 | |
| PRIDE | P0AE70 | |
| EnsemblBacteria | AAC75824 BAE76856 | |
| GeneID | 947252 | |
| KEGG | ecj:JW2753 eco:b2782 | |
| PATRIC | fig|1411691.4.peg.3953 | |
| EchoBASE | EB1229 | |
| EcoGene | EG11249 | |
| eggNOG | ENOG4105MZG COG2337 | |
| HOGENOM | HOG000290185 | |
| InParanoid | P0AE70 | |
| KO | K07171 | |
| PhylomeDB | P0AE70 | |
| BioCyc | EcoCyc:EG11249-MONOMER MetaCyc:EG11249-MONOMER | |
| EvolutionaryTrace | P0AE70 | |
| PRO | PR:P0AE70 | |
| Proteomes | UP000000318 UP000000625 | |
| GO | GO:0043234 GO:0003677 GO:0004521 GO:0032403 GO:0042803 GO:0003723 GO:0051607 GO:0006402 GO:0030308 GO:0051291 GO:0009372 GO:0006355 GO:0006417 GO:0016075 GO:0006351 | |
| Gene3D | 2.30.30.110 | |
| InterPro | IPR003477 IPR011067 | |
| Pfam | PF02452 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051291 |
protein heterooligomerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016075 |
rRNA catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006402 |
mRNA catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030308 |
negative regulation of cell growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004521 |
endoribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0043068 |
positive regulation of programmed cell death |
ECO:0000315 |
P |
Fig (1a,b,c) shows that more E.coli cells with a disrupted mazEF gene survived treatment with the antibiotics rifampin, chloramphenicol, and spectinomycin (all of which inhibit transcription) than wild type cells. |
complete | |||||
|
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004519 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004518 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090502 |
RNA phosphodiester bond hydrolysis, endonucleolytic |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004521 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009372 |
quorum sensing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004519 |
endonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006417 |
regulation of translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Zhang, Y et al. (2005) Insights into the mRNA cleavage mechanism by MazF, an mRNA interferase. J. Biol. Chem. 280 3143-50 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Kamada, K et al. (2003) Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition. Mol. Cell 11 875-84 PubMed GONUTS page
- ↑ Vesper, O et al. (2011) Selective translation of leaderless mRNAs by specialized ribosomes generated by MazF in Escherichia coli. Cell 147 147-57 PubMed GONUTS page
- ↑ 4.0 4.1 Christensen, SK et al. (2003) Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA. J. Mol. Biol. 332 809-19 PubMed GONUTS page
- ↑ Aizenman, E et al. (1996) An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death. Proc. Natl. Acad. Sci. U.S.A. 93 6059-63 PubMed GONUTS page
- ↑ Sat, B et al. (2001) Programmed cell death in Escherichia coli: some antibiotics can trigger mazEF lethality. J. Bacteriol. 183 2041-5 PubMed GONUTS page
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