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ECOLI:KAD

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) adk (ECO:0000255 with HAMAP-Rule:MF_00235) (synonyms: dnaW, plsA)
Protein Name(s) Adenylate kinase (ECO:0000255 with HAMAP-Rule:MF_00235)

AK (ECO:0000255 with HAMAP-Rule:MF_00235) ATP-AMP transphosphorylase (ECO:0000255 with HAMAP-Rule:MF_00235) ATP:AMP phosphotransferase (ECO:0000255 with HAMAP-Rule:MF_00235) Adenylate monophosphate kinase (ECO:0000255 with HAMAP-Rule:MF_00235)

External Links
UniProt P69441
EMBL X03038
U82664
U00096
AP009048
M38777
D90259
PIR A24275
RefSeq NP_415007.1
YP_488765.1
PDB 1AKE
1ANK
1E4V
1E4Y
2ECK
3HPQ
3HPR
4AKE
PDBsum 1AKE
1ANK
1E4V
1E4Y
2ECK
3HPQ
3HPR
4AKE
ProteinModelPortal P69441
SMR P69441
DIP DIP-47903N
IntAct P69441
STRING 511145.b0474
PhosSite P0809368
SWISS-2DPAGE P69441
PaxDb P69441
PRIDE P69441
EnsemblBacteria AAC73576
BAE76253
GeneID 12932619
945097
KEGG ecj:Y75_p0461
eco:b0474
PATRIC 32116105
EchoBASE EB0031
EcoGene EG10032
eggNOG COG0563
HOGENOM HOG000238772
InParanoid P69441
KO K00939
OMA TAYHKID
OrthoDB EOG679TH4
PhylomeDB P69441
BioCyc EcoCyc:ADENYL-KIN-MONOMER
ECOL316407:JW0463-MONOMER
MetaCyc:ADENYL-KIN-MONOMER
SABIO-RK P69441
UniPathway UPA00588
EvolutionaryTrace P69441
PRO PR:P69441
Proteomes UP000000318
UP000000625
Genevestigator P69441
GO GO:0005829
GO:0004017
GO:0016208
GO:0005524
GO:0000287
GO:0006172
GO:0044209
GO:0046939
GO:0008654
GO:0015951
GO:0032774
GO:0006412
Gene3D 3.40.50.300
HAMAP MF_00235
InterPro IPR006259
IPR000850
IPR007862
IPR027417
PANTHER PTHR23359
Pfam PF05191
PRINTS PR00094
SUPFAM SSF52540
TIGRFAMs TIGR01351
PROSITE PS00113

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0032774

RNA biosynthetic process

PMID:166976[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008654

phospholipid biosynthetic process

PMID:166976[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006412

translation

PMID:166976[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006172

ADP biosynthetic process

PMID:166976[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004017

adenylate kinase activity

PMID:166976[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:19029291[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016208

AMP binding

PMID:10736163[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0015951

purine ribonucleotide interconversion

PMID:166976[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:17309111[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:17272300[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15911532[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:10736163[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004017

adenylate kinase activity

PMID:6311616[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:19029291[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046940

nucleoside monophosphate phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004017

P

Seeded From UniProt

complete

involved_in

GO:0046940

nucleoside monophosphate phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004017

P

Seeded From UniProt

complete

involved_in

GO:0046940

nucleoside monophosphate phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004017

P

Seeded From UniProt

complete

involved_in

GO:0046940

nucleoside monophosphate phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004017

P

Seeded From UniProt

complete

involved_in

GO:0046940

nucleoside monophosphate phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004017

P

Seeded From UniProt

complete

enables

GO:0004017

adenylate kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006259
InterPro:IPR007862

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000850
InterPro:IPR006259

F

Seeded From UniProt

complete

involved_in

GO:0006139

nucleobase-containing compound metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000850

P

Seeded From UniProt

complete

enables

GO:0016776

phosphotransferase activity, phosphate group as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006259

F

Seeded From UniProt

complete

enables

GO:0019205

nucleobase-containing compound kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000850

F

Seeded From UniProt

complete

enables

GO:0004017

adenylate kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.4.3

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000333685

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000333685

C

Seeded From UniProt

complete

involved_in

GO:0009165

nucleotide biosynthetic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000333685

P

Seeded From UniProt

complete

enables

GO:0004017

adenylate kinase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000333685

F

Seeded From UniProt

complete

involved_in

GO:0009165

nucleotide biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0545

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0044209

AMP salvage

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00588

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Glaser, M et al. (1975) Role of adenylate kinase in the regulation of macromolecular biosynthesis in a putative mutant of Escherichia coli defective in membrane phospholipid biosynthesis. J. Bacteriol. 123 128-36 PubMed GONUTS page
  2. ↑ 2.0 2.1 Tan, YW et al. (2009) Direct Mg(2+) binding activates adenylate kinase from Escherichia coli. J. Biol. Chem. 284 3306-13 PubMed GONUTS page
  3. ↑ 3.0 3.1 Lin, Y & Nageswara Rao, BD (2000) Structural characterization of adenine nucleotides bound to Escherichia coli adenylate kinase. 2. 31P and 13C relaxation measurements in the presence of cobalt(II) and manganese(II). Biochemistry 39 3647-55 PubMed GONUTS page
  4. ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  5. ↑ Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page
  6. ↑ Watt, RM et al. (2007) Visualizing the proteome of Escherichia coli: an efficient and versatile method for labeling chromosomal coding DNA sequences (CDSs) with fluorescent protein genes. Nucleic Acids Res. 35 e37 PubMed GONUTS page
  7. ↑ Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page
  8. ↑ Bârzu, O & Michelson, S (1983) Simple and fast purification of Escherichia coli adenylate kinase. FEBS Lett. 153 280-4 PubMed GONUTS page
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