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ECOLI:ACRB

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) acrB (synonyms: acrE)
Protein Name(s) Multidrug efflux pump subunit AcrB

AcrAB-TolC multidrug efflux pump subunit AcrB Acridine resistance protein B

External Links
UniProt P31224
EMBL M94248
U00734
U82664
U00096
AP009048
PIR B36938
RefSeq NP_414995.1
YP_488753.1
PDB 1IWG
1OY6
1OY8
1OY9
1OYD
1OYE
1T9T
1T9U
1T9V
1T9W
1T9X
1T9Y
2DHH
2DR6
2DRD
2GIF
2HQC
2HQD
2HQF
2HQG
2HRT
2I6W
2J8S
2RDD
2W1B
3AOA
3AOB
3AOC
3AOD
3D9B
3NOC
3NOG
3W9H
4C48
4CDI
4DX5
4DX6
4DX7
4K7Q
4U8V
4U8Y
4U95
4U96
PDBsum 1IWG
1OY6
1OY8
1OY9
1OYD
1OYE
1T9T
1T9U
1T9V
1T9W
1T9X
1T9Y
2DHH
2DR6
2DRD
2GIF
2HQC
2HQD
2HQF
2HQG
2HRT
2I6W
2J8S
2RDD
2W1B
3AOA
3AOB
3AOC
3AOD
3D9B
3NOC
3NOG
3W9H
4C48
4CDI
4DX5
4DX6
4DX7
4K7Q
4U8V
4U8Y
4U95
4U96
ProteinModelPortal P31224
SMR P31224
DIP DIP-9049N
IntAct P31224
MINT MINT-1286285
STRING 511145.b0462
BindingDB P31224
ChEMBL CHEMBL1681614
TCDB 2.A.6.2.2
PaxDb P31224
PRIDE P31224
EnsemblBacteria AAC73564
BAE76241
GeneID 12930865
945108
KEGG ecj:Y75_p0449
eco:b0462
PATRIC 32116077
EchoBASE EB1655
EcoGene EG11704
eggNOG COG0841
HOGENOM HOG000158129
InParanoid P31224
KO K18138
OMA WSGLSYE
OrthoDB EOG683S5M
PhylomeDB P31224
BioCyc EcoCyc:ACRB-MONOMER
ECOL316407:JW0451-MONOMER
RETL1328306-WGS:GSTH-3471-MONOMER
EvolutionaryTrace P31224
PRO PR:P31224
Proteomes UP000000318
UP000000625
Genevestigator P31224
GO GO:0005887
GO:0016020
GO:0015238
GO:0015307
GO:0046618
GO:0006855
GO:0042493
Gene3D 3.30.2090.10
InterPro IPR027463
IPR001036
IPR004764
Pfam PF00873
PRINTS PR00702
SUPFAM SSF82714
TIGRFAMs TIGR00915

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0016020

membrane

PMID:16858726[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25451234[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31224

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:23812586[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31224

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22451937[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31224

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22121023[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31224

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18223659[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31224

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16915237[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31224

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16079137[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31224

F

Seeded From UniProt

complete

part_of

GO:1990281

efflux pump complex

PMID:15155734[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02930
UniProtKB:P0AE06

C

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:8407802[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0015307

obsolete drug:proton antiporter activity

PMID:10377390[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0015238

drug transmembrane transporter activity

PMID:8407802[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006855

drug transmembrane transport

PMID:8550435[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:8407802[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:8407802[10]

ECO:0000245

automatically integrated combinatorial evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:17309111[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15919996[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046618

drug export

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015307

P

Seeded From UniProt

complete

involved_in

GO:0006855

drug transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004764

P

Seeded From UniProt

complete

enables

GO:0015562

efflux transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004764

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001036

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004764

C

Seeded From UniProt

complete

enables

GO:0022857

transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001036

F

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001036

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-KW:KW-0997
UniProtKB-SubCell:SL-0037

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed GONUTS page
  2. ↑ Ly, K et al. (2014) A novel packing arrangement of AcrB in the lipid bilayer membrane. FEBS Lett. 588 4776-83 PubMed GONUTS page
  3. ↑ Nakashima, R et al. (2013) Structural basis for the inhibition of bacterial multidrug exporters. Nature 500 102-6 PubMed GONUTS page
  4. ↑ Eicher, T et al. (2012) Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc. Natl. Acad. Sci. U.S.A. 109 5687-92 PubMed GONUTS page
  5. ↑ Nakashima, R et al. (2011) Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket. Nature 480 565-9 PubMed GONUTS page
  6. ↑ Seeger, MA et al. (2008) Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB. Nat. Struct. Mol. Biol. 15 199-205 PubMed GONUTS page
  7. ↑ Murakami, S et al. (2006) Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 443 173-9 PubMed GONUTS page
  8. ↑ Stenberg, F et al. (2005) Protein complexes of the Escherichia coli cell envelope. J. Biol. Chem. 280 34409-19 PubMed GONUTS page
  9. ↑ Tikhonova, EB & Zgurskaya, HI (2004) AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex. J. Biol. Chem. 279 32116-24 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 Ma, D et al. (1993) Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J. Bacteriol. 175 6299-313 PubMed GONUTS page
  11. ↑ Zgurskaya, HI & Nikaido, H (1999) Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 96 7190-5 PubMed GONUTS page
  12. ↑ Okusu, H et al. (1996) AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J. Bacteriol. 178 306-8 PubMed GONUTS page
  13. ↑ Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page
  14. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page
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