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ECOBD:C5W9C5

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Species (Taxon ID) Escherichia coli (strain B / BL21-DE3). (469008)
Gene Name(s) No Information Provided. (synonyms: hflB (ECO:0000313 with EMBL:ACT44847.1))
Protein Name(s) ATP-dependent zinc metalloprotease FtsH (ECO:0000256 with HAMAP-Rule:MF_01458)
External Links
UniProt C5W9C5
EMBL CP001509
AM946981
RefSeq YP_003000752.1
YP_003055618.1
ProteinModelPortal C5W9C5
SMR C5W9C5
EnsemblBacteria ACT44847
CAQ33511
GeneID 8113130
8179941
KEGG ebe:B21_02994
ebl:ECD_03043
eggNOG COG0465
HOGENOM HOG000217276
KO K03798
Proteomes UP000001509
UP000009074
GO GO:0016021
GO:0005886
GO:0005524
GO:0016887
GO:0004222
GO:0008270
GO:0030163
Gene3D 3.40.50.300
HAMAP MF_01458
InterPro IPR003593
IPR003959
IPR003960
IPR005936
IPR027417
IPR011546
IPR000642
Pfam PF00004
PF06480
PF01434
SMART SM00382
SUPFAM SSF52540
TIGRFAMs TIGR01241
PROSITE PS00674

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006508

proteolysis

PMID:10809689[1]

IDA: Inferred from Direct Assay

P

Figure 4 demonstrates proteolysis of β-casein by FtsH.

complete

GO:0006508

proteolysis

PMID:9712851[2]

IDA: Inferred from Direct Assay

P

Figure 2 shows in vivo degradation of the λCII protein

complete

GO:0016021

integral to membrane

PMID:9712851[2]

IDA: Inferred from Direct Assay

C

Figure 5 shows impaired FtsH-FtsH interaction by a periplasmic deletion.

complete

GO:0000166

nucleotide binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded From UniProt

complete

GO:0000166

nucleotide binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0004222

metalloendopeptidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000642
InterPro:IPR005936
InterPro:IPR011546

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000642
InterPro:IPR003959
InterPro:IPR003960
InterPro:IPR011546

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01458

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0997

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000040

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0037

C

Seeded From UniProt

complete

GO:0006200

obsolete ATP catabolic process

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01458

P

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000642

P

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

GO:0008233

peptidase activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01458

F

Seeded From UniProt

complete

GO:0008233

peptidase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

GO:0008237

metallopeptidase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0482

F

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011546

F

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01458

F

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005936

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011546

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0016887

ATPase activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01458

F

Seeded From UniProt

complete

GO:0017111

nucleoside-triphosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded From UniProt

complete

GO:0030163

protein catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005936

P

Seeded From UniProt

complete

GO:0030163

protein catabolic process

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01458

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Shotland, Y et al. (2000) Proteolysis of bacteriophage lambda CII by Escherichia coli FtsH (HflB). J. Bacteriol. 182 3111-6 PubMed GONUTS page
  2. 2.0 2.1 Akiyama, Y et al. (1998) Roles of the periplasmic domain of Escherichia coli FtsH (HflB) in protein interactions and activity modulation. J. Biol. Chem. 273 22326-33 PubMed GONUTS page