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DROME:TRH

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) trh
Protein Name(s) Protein trachealess
External Links
UniProt Q24119
EMBL U33427
U42699
AE014296
AE014296
BT031114
AY094911
RefSeq NP_001036575.1
NP_001097461.2
NP_001261207.1
NP_523872.2
UniGene Dm.7330
ProteinModelPortal Q24119
SMR Q24119
BioGrid 63620
EnsemblMetazoa FBtr0330146
GeneID 38065
KEGG dme:Dmel_CG42865
CTD 7200
FlyBase FBgn0262139
eggNOG NOG287666
GeneTree ENSGT00760000118788
InParanoid Q24119
KO K09098
OMA PMPVLLM
OrthoDB EOG718KBW
GenomeRNAi 38065
NextBio 806807
PRO PR:Q24119
Proteomes UP000000803
Bgee Q24119
ExpressionAtlas Q24119
GO GO:0005634
GO:0046982
GO:0043565
GO:0000981
GO:0003700
GO:0004871
GO:0048813
GO:0007425
GO:0072175
GO:0046331
GO:0007443
GO:0007424
GO:0045944
GO:0007431
GO:0007435
GO:0035277
GO:0006366
InterPro IPR011598
IPR001610
IPR000014
IPR013767
IPR013655
Pfam PF00989
PF08447
SMART SM00353
SM00086
SM00091
SUPFAM SSF47459
SSF55785
PROSITE PS50888
PS50112

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0007424

open tracheal system development

PMID:21963537[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007431

salivary gland development

PMID:8557198[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007424

open tracheal system development

PMID:8557198[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8557198[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P05709

C

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0039411
FB:FBgn0262139
FB:FBgn0266411
MGI:MGI:106918
MGI:MGI:109169
MGI:MGI:2664186
PANTHER:PTN001127032
RGD:61928
RGD:68404
RGD:70332
UniProtKB:Q16665
UniProtKB:Q8IUM7
UniProtKB:Q99814
WB:WBGene00000521
WB:WBGene00001851

P

Seeded From UniProt

complete

GO:0007424

open tracheal system development

PMID:21963537[1]

ECO:0000315

P

Fig 2 shows tracheal gene expression is absent in trh mutants.

complete
CACAO 6744

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0039411
PANTHER:PTN000548738
UniProtKB:Q9Y2N7

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004666
FB:FBgn0039411
FB:FBgn0262139
FB:FBgn0266411
MGI:MGI:106918
MGI:MGI:109169
MGI:MGI:109205
MGI:MGI:1351610
MGI:MGI:1859778
MGI:MGI:2664186
MGI:MGI:98306
MGI:MGI:98307
PANTHER:PTN000548738
RGD:61928
RGD:68404
RGD:70332
UniProtKB:Q16665
UniProtKB:Q9XTA5
WB:WBGene00001851

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106918
MGI:MGI:2664186
PANTHER:PTN000548738
UniProtKB:Q8IUM7

F

Seeded From UniProt

complete

contributes_to

GO:0003700

DNA-binding transcription factor activity

PMID:21061019[4]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0264075

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21061019[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21693579[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:17652079[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:17652079[6]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0264075

F

Seeded From UniProt

complete

involved_in

GO:0060173

limb development

PMID:17187773[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007435

salivary gland morphogenesis

PMID:12798300[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007431

salivary gland development

PMID:12742168[9]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007425

epithelial cell fate determination, open tracheal system

PMID:11740943[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007443

Malpighian tubule morphogenesis

PMID:10502111[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035277

spiracle morphogenesis, open tracheal system

PMID:10491268[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

contributes_to

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:9409674[13]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0264075

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:9409674[13]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0264075

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:8557189[14]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0004666

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8557189[14]

ECO:0000250

sequence similarity evidence used in manual assertion

HGNC:4910

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:8557189[14]

ECO:0000250

sequence similarity evidence used in manual assertion

HGNC:4910

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8557189[14]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0004666

C

Seeded From UniProt

complete

involved_in

GO:0072175

epithelial tube formation

PMID:8557189[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035202

tracheal pit formation in open tracheal system

PMID:16818611[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013767

P

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011598
InterPro:IPR036638

F

Seeded From UniProt

complete

involved_in

GO:0007424

open tracheal system development

PMID:11598957[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007435

salivary gland morphogenesis

PMID:11598957[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Chung, S et al. (2011) Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis. Dev. Biol. 360 160-72 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Wilk, R et al. (1996) trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila. Genes Dev. 10 93-102 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 Morozova, T et al. (2010) The Drosophila jing gene is a downstream target in the Trachealess/Tango tracheal pathway. Dev. Genes Evol. 220 191-206 PubMed GONUTS page
  5. ↑ Araújo, SJ & Casanova, J (2011) Sequoia establishes tip-cell number in Drosophila trachea by regulating FGF levels. J. Cell. Sci. 124 2335-40 PubMed GONUTS page
  6. ↑ 6.0 6.1 Jiang, L & Crews, ST (2007) Transcriptional specificity of Drosophila dysfusion and the control of tracheal fusion cell gene expression. J. Biol. Chem. 282 28659-68 PubMed GONUTS page
  7. ↑ Tajiri, R et al. (2007) Fate determination of Drosophila leg distal regions by trachealess and tango through repression and stimulation, respectively, of Bar homeobox gene expression in the future pretarsus and tarsus. Dev. Biol. 303 461-73 PubMed GONUTS page
  8. ↑ Haberman, AS et al. (2003) Specification of cell fates within the salivary gland primordium. Dev. Biol. 258 443-53 PubMed GONUTS page
  9. ↑ Abrams, EW et al. (2003) Constructing an organ: the Drosophila salivary gland as a model for tube formation. Trends Cell Biol. 13 247-54 PubMed GONUTS page
  10. ↑ Jin, J et al. (2001) Regulation of Drosophila tracheal system development by protein kinase B. Dev. Cell 1 817-27 PubMed GONUTS page
  11. ↑ Jack, J & Myette, G (1999) Mutations that alter the morphology of the malpighian tubules in Drosophila. Dev. Genes Evol. 209 546-54 PubMed GONUTS page
  12. ↑ Hu, N & Castelli-Gair, J (1999) Study of the posterior spiracles of Drosophila as a model to understand the genetic and cellular mechanisms controlling morphogenesis. Dev. Biol. 214 197-210 PubMed GONUTS page
  13. ↑ 13.0 13.1 Sonnenfeld, M et al. (1997) The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development. Development 124 4571-82 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 14.3 14.4 Isaac, DD & Andrew, DJ (1996) Tubulogenesis in Drosophila: a requirement for the trachealess gene product. Genes Dev. 10 103-17 PubMed GONUTS page
  15. ↑ Brodu, V & Casanova, J (2006) The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination. Genes Dev. 20 1817-28 PubMed GONUTS page
  16. ↑ 16.0 16.1 Bradley, PL et al. (2001) Organ formation in Drosophila: specification and morphogenesis of the salivary gland. Bioessays 23 901-11 PubMed GONUTS page
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