DROME:TRA2

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	tra2 (synonyms: tra-2)
Protein Name(s)	Transformer-2 sex-determining protein
External Links
UniProt	P19018
EMBL	M23633 X57484 M30939 M30939 M30939 M30939 M76381 AE013599 AE013599 AE013599 AE013599 AE013599 AE013599 AY058768 J03155
PIR	A32373 D35846 S12003
RefSeq	NP_476763.1 NP_476764.1 NP_476765.1 NP_476766.1 NP_599107.1 NP_995834.1 NP_995835.1
UniGene	Dm.4216
ProteinModelPortal	P19018
SMR	P19018
BioGrid	62366
DIP	DIP-17430N
IntAct	P19018
MINT	MINT-277223
PaxDb	P19018
PRIDE	P19018
EnsemblMetazoa	FBtr0089617 FBtr0089620 FBtr0089621
GeneID	36619
KEGG	dme:Dmel_CG10128
CTD	36619
FlyBase	FBgn0003742
eggNOG	NOG297815
GeneTree	ENSGT00710000106295
InParanoid	P19018
KO	K12897
OMA	SITERPH
OrthoDB	EOG7SFHZZ
PhylomeDB	P19018
GenomeRNAi	36619
NextBio	799520
Proteomes	UP000000803
Bgee	P19018
GO	GO:0071011 GO:0042802 GO:0003729 GO:0000166 GO:0036002 GO:0003723 GO:0030154 GO:0030237 GO:0019101 GO:0019102 GO:0006397 GO:0000398 GO:0000381 GO:0000003 GO:0007530 GO:0007548 GO:0007283 GO:0000245
Gene3D	3.30.70.330
InterPro	IPR012677 IPR000504
Pfam	PF00076
SMART	SM00360
PROSITE	PS50102

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0030237	female sex determination	PMID:2116360^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030237	female sex determination	PMID:2120049^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007530	sex determination	PMID:3144434^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	PMID:2493992^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	PMID:1674449^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:8124712^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:3144434^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:8334698^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:8124712^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000003	reproduction	PMID:2120049^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000003	reproduction	PMID:8124712^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001215 FB:FBgn0004237 FB:FBgn0004838 MGI:MGI:1916394 PANTHER:PTN002689974 UniProtKB:P09651 UniProtKB:P19338 UniProtKB:P22626 UniProtKB:Q14103 UniProtKB:Q96EP5 UniProtKB:Q99729	C	Seeded From UniProt	complete
involved_in	GO:0048026	positive regulation of mRNA splicing, via spliceosome	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106016 PANTHER:PTN000391532 RGD:1306751 UniProtKB:P62995	P	Seeded From UniProt	complete
part_of	GO:0005681	spliceosomal complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000391532 UniProtKB:P62995	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104819 MGI:MGI:1330294 MGI:MGI:893588 MGI:MGI:97286 PANTHER:PTN002689974 RGD:1306751 RGD:1310403 RGD:1310906 RGD:3153 RGD:69234 SGD:S000003391 SGD:S000005483 TAIR:locus:2019622 TAIR:locus:2076096 TAIR:locus:2079874 TAIR:locus:2083810 TAIR:locus:2122009 TAIR:locus:2159401 TAIR:locus:2179939 UniProtKB:P19338 UniProtKB:P22626 UniProtKB:P38159 UniProtKB:P62995 UniProtKB:Q03250 UniProtKB:Q13148 UniProtKB:Q14103 UniProtKB:Q9SVM8	F	Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:19218244^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:18981222^[10]	ECO:0000305	curator inference used in manual assertion	GO:0071011	P	Seeded From UniProt	complete
part_of	GO:0071011	precatalytic spliceosome	PMID:18981222^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007530	sex determination	PMID:12486700^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007530	sex determination	PMID:11092827^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:10908586^[13]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
involved_in	GO:0000245	spliceosomal complex assembly	PMID:10648226^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:8970731^[15]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:8124712^[6]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0003742	F	Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:8124712^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0036002	pre-mRNA binding	PMID:8124712^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:1518835^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0036002	pre-mRNA binding	PMID:1518835^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000504 InterPro:IPR035979	F	Seeded From UniProt	complete
involved_in	GO:0019101	female somatic sex determination	PMID:8970731^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019102	male somatic sex determination	PMID:8970731^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0744	P	Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0508	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0007548	sex differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0726	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mattox, W et al. (1990) Alternative splicing of the sex determination gene transformer-2 is sex-specific in the germ line but not in the soma. Genes Dev. 4 789-805 PubMed GONUTS page
↑ ^2.0 ^2.1 Amrein, H et al. (1990) Alternatively spliced transcripts of the sex-determining gene tra-2 of Drosophila encode functional proteins of different size. EMBO J. 9 3619-29 PubMed GONUTS page
↑ ^3.0 ^3.1 Amrein, H et al. (1988) The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein. Cell 55 1025-35 PubMed GONUTS page
↑ Goralski, TJ et al. (1989) The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins. Cell 56 1011-8 PubMed GONUTS page
↑ Hedley, ML & Maniatis, T (1991) Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell 65 579-86 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Amrein, H et al. (1994) The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. Cell 76 735-46 PubMed GONUTS page
↑ Tian, M & Maniatis, T (1993) A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell 74 105-14 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Katzenberger, RJ et al. (2009) Control of alternative splicing by signal-dependent degradation of splicing-regulatory proteins. J. Biol. Chem. 284 10737-46 PubMed GONUTS page
↑ ^10.0 ^10.1 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page
↑ Emmons, SW & Lipton, J (2003) Genetic basis of male sexual behavior. J. Neurobiol. 54 93-110 PubMed GONUTS page
↑ Greenspan, RJ & Ferveur, JF (2000) Courtship in Drosophila. Annu. Rev. Genet. 34 205-232 PubMed GONUTS page
↑ Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
↑ Schütt, C & Nöthiger, R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127 667-77 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Williamson, A & Lehmann, R (1996) Germ cell development in Drosophila. Annu. Rev. Cell Dev. Biol. 12 365-91 PubMed GONUTS page
↑ ^16.0 ^16.1 Inoue, K et al. (1992) Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing. Proc. Natl. Acad. Sci. U.S.A. 89 8092-6 PubMed GONUTS page

[PMID:2116360-1] Mattox, W et al. (1990) Alternative splicing of the sex determination gene transformer-2 is sex-specific in the germ line but not in the soma. Genes Dev. 4 789-805 PubMed GONUTS page

[PMID:2120049-2] 2.0 ^2.1 Amrein, H et al. (1990) Alternatively spliced transcripts of the sex-determining gene tra-2 of Drosophila encode functional proteins of different size. EMBO J. 9 3619-29 PubMed GONUTS page

[PMID:3144434-3] 3.0 ^3.1 Amrein, H et al. (1988) The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein. Cell 55 1025-35 PubMed GONUTS page

[PMID:2493992-4] Goralski, TJ et al. (1989) The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins. Cell 56 1011-8 PubMed GONUTS page

[PMID:1674449-5] Hedley, ML & Maniatis, T (1991) Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell 65 579-86 PubMed GONUTS page

[PMID:8124712-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Amrein, H et al. (1994) The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. Cell 76 735-46 PubMed GONUTS page

[PMID:8334698-7] Tian, M & Maniatis, T (1993) A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell 74 105-14 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19218244-9] Katzenberger, RJ et al. (2009) Control of alternative splicing by signal-dependent degradation of splicing-regulatory proteins. J. Biol. Chem. 284 10737-46 PubMed GONUTS page

[PMID:18981222-10] 10.0 ^10.1 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page

[PMID:12486700-11] Emmons, SW & Lipton, J (2003) Genetic basis of male sexual behavior. J. Neurobiol. 54 93-110 PubMed GONUTS page

[PMID:11092827-12] Greenspan, RJ & Ferveur, JF (2000) Courtship in Drosophila. Annu. Rev. Genet. 34 205-232 PubMed GONUTS page

[PMID:10908586-13] Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page

[PMID:10648226-14] Schütt, C & Nöthiger, R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127 667-77 PubMed GONUTS page

[PMID:8970731-15] 15.0 ^15.1 ^15.2 Williamson, A & Lehmann, R (1996) Germ cell development in Drosophila. Annu. Rev. Cell Dev. Biol. 12 365-91 PubMed GONUTS page

[PMID:1518835-16] 16.0 ^16.1 Inoue, K et al. (1992) Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing. Proc. Natl. Acad. Sci. U.S.A. 89 8092-6 PubMed GONUTS page

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DROME:TRA2

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Annotations

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