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PMID:3144434
| Citation |
Amrein, H, Gorman, M and Nöthiger, R (1988) The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein. Cell 55:1025-35 |
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| Abstract |
The gene transformer-2 (tra-2) of Drosophila is necessary not only for female sexual differentiation but also for normal spermatogenesis in males. We have cloned and characterized the tra-2 gene. Its putative protein has a domain that is homologous to RNA binding proteins. This suggests that the tra-2 protein might achieve the female-specific splicing of the transcript of dsx, a sex-determining gene whose mode of expression depends on tra-2. The protein coding region of the tra-2 transcript is identical in males and females. In both sexes, a low level of transcript is present in the soma and a high level in the germ line. This indicates that tra-2 is regulated in a way different from other sex-determining genes. |
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| Keywords |
Animals; Base Sequence; Carrier Proteins/genetics; Cloning, Molecular; Drosophila/genetics; Female; Gene Expression Regulation; Male; Molecular Sequence Data; RNA-Binding Proteins; Sex Differentiation; Spermatogenesis; Transcription, Genetic |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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