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DROME:TERA

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) TER94 (synonyms: VCP)
Protein Name(s) Transitional endoplasmic reticulum ATPase TER94

Valosin-containing protein homolog

External Links
UniProt Q7KN62
EMBL AF047037
AF202034
AE013599
AE013599
AE013599
AF132553
RefSeq NP_001097249.1
NP_001097250.1
NP_477369.1
UniGene Dm.2968
ProteinModelPortal Q7KN62
SMR Q7KN62
BioGrid 61868
IntAct Q7KN62
PaxDb Q7KN62
PRIDE Q7KN62
EnsemblMetazoa FBtr0088391
GeneID 36040
KEGG dme:Dmel_CG2331
UCSC CG2331-RA
CTD 36040
FlyBase FBgn0261014
eggNOG COG0464
GeneTree ENSGT00740000115575
InParanoid Q7KN62
KO K13525
OMA SQDTIIH
OrthoDB EOG7H4DSW
PhylomeDB Q7KN62
Reactome REACT_227922
REACT_234235
REACT_258701
GenomeRNAi 36040
NextBio 796507
PRO PR:Q7KN62
Proteomes UP000000803
Bgee Q7KN62
ExpressionAtlas Q7KN62
GO GO:0005737
GO:0045169
GO:0005811
GO:0005875
GO:0031965
GO:0005634
GO:0043186
GO:0005886
GO:0000502
GO:0005524
GO:0016787
GO:0006200
GO:0098586
GO:0048813
GO:0016320
GO:0007029
GO:0030433
GO:0007030
GO:0000226
GO:0048477
GO:0007279
GO:0043525
GO:0032436
GO:0046598
GO:0006508
GO:0043523
GO:0007317
GO:0006810
GO:0006511
Gene3D 3.10.330.10
3.40.50.300
InterPro IPR003593
IPR005938
IPR009010
IPR003959
IPR003960
IPR004201
IPR029067
IPR003338
IPR027417
IPR015415
Pfam PF00004
PF02933
PF02359
PF09336
SMART SM00382
SM01072
SM01073
SUPFAM SSF50692
SSF52540
SSF54585
TIGRFAMs TIGR01243
PROSITE PS00674

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046907

intracellular transport

PMID:23790629[1]

ECO:0000255

PMID:19131956[2]


P

Table 1.Valosin-containing protein (VCP) homologue function categorized by DAVID and receiving the highest MASCOT score in anti-myc affinity purification and mass-spectrometry with the protein atlastin.

complete
CACAO 8890

GO:0016485

protein processing

PMID:23790629[1]

ECO:0000317

PMID:14597658[3] PMID:19131956[2] PMID:22641854[4]


P

Fig. 1B. Proteins are identified through DAVID and again through DroPNet and constructed into a web through Cytoscape. Valosin-containing protein (VCP) homologue (TER94) is found in th protein processing section of the atlastin interactome web.

complete
CACAO 9003

GO:0016485

protein processing

PMID:23790629[1]

ECO:0000316

UniProtKB:Q9VC57


P

Fig. 2A. VCP is confirmed to interact with atlastin, known to function in protein processing, through co-immunoprecipitation.

complete
CACAO 9005

GO:0007029

endoplasmic reticulum organization

PMID:23790629[1]

ECO:0000314

P

Fig. 2B,C, and D all show atlastin and VCP in ER regions.

complete
CACAO 9007

GO:0016485

protein processing

PMID:23790629[1]

ECO:0000315

P

Fig. 4. VCP contributes to atlastin function. VCP expression directly influences atlastin expression as seen by large or rough eyes.

complete
CACAO 9008

GO:0016485

protein processing

PMID:23790629[1]

ECO:0000314

P

Fig. 5. Loss of VCP causes a suppression of the atlastin overexpression phenotype, rough or small eyes.

complete
CACAO 9010

involved_in

GO:0097352

autophagosome maturation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261014
PANTHER:PTN000554506
UniProtKB:P55072

P

Seeded From UniProt

complete

involved_in

GO:0071712

ER-associated misfolded protein catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554506
SGD:S000002284
UniProtKB:P55072
WB:WBGene00007352
WB:WBGene00008053

P

Seeded From UniProt

complete

involved_in

GO:0051228

mitotic spindle disassembly

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554506
PomBase:SPAC1565.08
SGD:S000002284

P

Seeded From UniProt

complete

part_of

GO:0034098

VCP-NPL4-UFD1 AAA ATPase complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99919
PANTHER:PTN000554506
RGD:621595
SGD:S000002284
WB:WBGene00007352
WB:WBGene00008053

C

Seeded From UniProt

complete

enables

GO:0031593

polyubiquitin modification-dependent protein binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99919
PANTHER:PTN000554506
UniProtKB:P55072

F

Seeded From UniProt

complete

involved_in

GO:0030970

retrograde protein transport, ER to cytosol

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99919
PANTHER:PTN000554506
SGD:S000002284
UniProtKB:P55072

P

Seeded From UniProt

complete

involved_in

GO:0030433

ubiquitin-dependent ERAD pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554506
SGD:S000002284
UniProtKB:P46468
UniProtKB:P55072

P

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99919
PANTHER:PTN000554398
RGD:621595
SGD:S000001680
SGD:S000002284
SGD:S000004389
SGD:S000005273
UniProtKB:P46468
UniProtKB:P55072
UniProtKB:P9WQN5
UniProtKB:Q13608
WB:WBGene00007352
WB:WBGene00008053
WB:WBGene00010562

F

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554506
SGD:S000002284
UniProtKB:P55072

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554506
RGD:621595
SGD:S000002284
TAIR:locus:2085064
TAIR:locus:2101933
TAIR:locus:2831844
UniProtKB:P55072

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261014
PANTHER:PTN000554506
PomBase:SPAC1565.08
TAIR:locus:2085064
UniProtKB:P55072
WB:WBGene00007352
dictyBase:DDB_G0288065

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554506
PomBase:SPAC1565.08
SGD:S000002284
TAIR:locus:2085064
UniProtKB:P55072
WB:WBGene00007352
WB:WBGene00008053

C

Seeded From UniProt

complete

involved_in

GO:0045786

negative regulation of cell cycle

PMID:30002129[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006530

asparagine catabolic process

PMID:30002129[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035096

larval midgut cell programmed cell death

PMID:24550005[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:25369031[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0044754

autolysosome

PMID:26167652[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007040

lysosome organization

PMID:26167652[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097352

autophagosome maturation

PMID:26167652[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046716

muscle cell cellular homeostasis

PMID:26167652[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:19317464[10]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24292889[11]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

PMID:24292889[11]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:24292889[11]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0098586

cellular response to virus

PMID:24332855[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046598

positive regulation of viral entry into host cell

PMID:24332855[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:19782090[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043523

regulation of neuron apoptotic process

PMID:21343367[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048813

dendrite morphogenesis

PMID:21343367[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0045169

fusome

PMID:18355804[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007279

pole cell formation

PMID:18590813[16]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0283442

P

Seeded From UniProt

complete

involved_in

GO:0007279

pole cell formation

PMID:18590813[16]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0003891

P

Seeded From UniProt

complete

part_of

GO:0043186

P granule

PMID:18590813[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:15899868[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000502

proteasome complex

PMID:15899868[17]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:15899868[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043525

positive regulation of neuron apoptotic process

PMID:11859409[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007029

endoplasmic reticulum organization

PMID:10656772[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000226

microtubule cytoskeleton organization

PMID:10656772[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016320

endoplasmic reticulum membrane fusion

PMID:10656772[19]

ECO:0000250

sequence similarity evidence used in manual assertion

SGD:S000002284

P

Seeded From UniProt

complete

involved_in

GO:0007317

regulation of pole plasm oskar mRNA localization

PMID:10656772[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007030

Golgi organization

PMID:10656772[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10564274[20]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045169

fusome

PMID:10564274[20]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:24550005[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003959
InterPro:IPR003960

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005938

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0048477

oogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0896

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 O'Sullivan, NC et al. (2013) Characterization of the Drosophila atlastin interactome reveals VCP as a functionally related interactor. J Genet Genomics 40 297-306 PubMed GONUTS page
  2. ↑ 2.0 2.1 Huang, da W et al. (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4 44-57 PubMed GONUTS page
  3. ↑ Shannon, P et al. (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13 2498-504 PubMed GONUTS page
  4. ↑ Renaud, Y et al. (2012) DroPNet: a web portal for integrated analysis of Drosophila protein-protein interaction networks. Nucleic Acids Res. 40 W134-9 PubMed GONUTS page
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 Zülbahar, S et al. (2018) Differential expression of Öbek controls ploidy in the blood-brain barrier. Development 145 PubMed GONUTS page
  7. ↑ 7.0 7.1 Santhanam, A et al. (2014) Ecdysone-induced receptor tyrosine phosphatase PTP52F regulates Drosophila midgut histolysis by enhancement of autophagy and apoptosis. Mol. Cell. Biol. 34 1594-606 PubMed GONUTS page
  8. ↑ Reim, G et al. (2014) Protection of armadillo/β-Catenin by armless, a novel positive regulator of wingless signaling. PLoS Biol. 12 e1001988 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 Johnson, AE et al. (2015) VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo. Elife 4 PubMed GONUTS page
  10. ↑ Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 Lee, SY et al. (2014) Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10. Cell. Mol. Life Sci. 71 2747-58 PubMed GONUTS page
  12. ↑ 12.0 12.1 Panda, D et al. (2013) Genome-wide RNAi screen identifies SEC61A and VCP as conserved regulators of Sindbis virus entry. Cell Rep 5 1737-48 PubMed GONUTS page
  13. ↑ Beskow, A et al. (2009) A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. J. Mol. Biol. 394 732-46 PubMed GONUTS page
  14. ↑ 14.0 14.1 Rumpf, S et al. (2011) Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1. Development 138 1153-60 PubMed GONUTS page
  15. ↑ Lighthouse, DV et al. (2008) New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev. Biol. 317 59-71 PubMed GONUTS page
  16. ↑ 16.0 16.1 16.2 Thomson, T et al. () Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins. Mech. Dev. 125 865-73 PubMed GONUTS page
  17. ↑ 17.0 17.1 17.2 Lundgren, J et al. (2005) Identification and characterization of a Drosophila proteasome regulatory network. Mol. Cell. Biol. 25 4662-75 PubMed GONUTS page
  18. ↑ Higashiyama, H et al. (2002) Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration. Cell Death Differ. 9 264-73 PubMed GONUTS page
  19. ↑ 19.0 19.1 19.2 19.3 19.4 Ruden, DM et al. (2000) Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber. Dev. Biol. 218 314-25 PubMed GONUTS page
  20. ↑ 20.0 20.1 León, A & McKearin, D (1999) Identification of TER94, an AAA ATPase protein, as a Bam-dependent component of the Drosophila fusome. Mol. Biol. Cell 10 3825-34 PubMed GONUTS page
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