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DROME:SRF

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) bs (synonyms: Serf)
Protein Name(s) Serum response factor homolog

dSRF Protein blistered

External Links
UniProt Q24535
EMBL X77532
AE013599
AY095071
PIR S42825
RefSeq NP_001286837.1
NP_726438.1
UniGene Dm.3381
ProteinModelPortal Q24535
SMR Q24535
BioGrid 63464
STRING 7227.FBpp0072178
PaxDb Q24535
EnsemblMetazoa FBtr0072271
GeneID 37890
KEGG dme:Dmel_CG3411
CTD 12213
FlyBase FBgn0004101
eggNOG COG5068
GeneTree ENSGT00400000022158
InParanoid Q24535
KO K04378
OrthoDB EOG76DTVJ
PhylomeDB Q24535
GenomeRNAi 37890
NextBio 805887
PRO PR:Q24535
Proteomes UP000000803
Bgee Q24535
ExpressionAtlas Q24535
GO GO:0005634
GO:0033613
GO:0003677
GO:0007475
GO:0030154
GO:0045165
GO:0007476
GO:0008586
GO:0002168
GO:0007424
GO:0045944
GO:0035209
GO:0007614
GO:0030431
GO:0007430
GO:0035154
GO:0006351
GO:0035220
InterPro IPR002100
Pfam PF00319
PRINTS PR00404
SMART SM00432
SUPFAM SSF55455
PROSITE PS00350
PS50066

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002168

instar larval development

PMID:9550715[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002100

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:15239956[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:7600954[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006366

transcription from RNA polymerase II promoter

PMID:15314239[4]

IPI: Inferred from Physical Interaction

FB:FBgn0052296

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007424

open tracheal system development

PMID:11128983[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007424

open tracheal system development

PMID:7600954[3]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0007430

terminal branching, open tracheal system

PMID:10684581[6]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007430

terminal branching, open tracheal system

PMID:14570584[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007430

terminal branching, open tracheal system

PMID:8625824[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007430

terminal branching, open tracheal system

PMID:8787734[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007475

apposition of dorsal and ventral imaginal disc-derived wing surfaces

PMID:9136017[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:10625531[11]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:12508275[12]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:12717815[13]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:16648592[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:9550715[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007614

short-term memory

PMID:24012317[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008586

imaginal disc-derived wing vein morphogenesis

PMID:15314239[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

PMID:9550715[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030431

sleep

PMID:19342592[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0033613

activating transcription factor binding

PMID:15314239[4]

IPI: Inferred from Physical Interaction

FB:FBgn0052296

F

Seeded From UniProt

complete

GO:0035154

terminal cell fate specification, open tracheal system

PMID:10684581[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0035154

terminal cell fate specification, open tracheal system

PMID:11063940[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0035154

terminal cell fate specification, open tracheal system

PMID:12791296[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0035209

pupal development

PMID:9550715[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035220

wing disc development

PMID:9550715[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045165

cell fate commitment

PMID:10625531[11]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:15314239[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0046983

protein dimerization activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002100

F

Seeded From UniProt

complete

contributes_to

GO:0001077

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding

PMID:15314239[4]

IPI: Inferred from Physical Interaction

FB:FBgn0052296

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Roch, F et al. (1998) Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing. Development 125 1823-32 PubMed GONUTS page
  2. Somogyi, K & Rørth, P (2004) Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration. Dev. Cell 7 85-93 PubMed GONUTS page
  3. 3.0 3.1 Affolter, M et al. (1994) The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development. Development 120 743-53 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Han, Z et al. (2004) A myocardin-related transcription factor regulates activity of serum response factor in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 12567-72 PubMed GONUTS page
  5. Wilson, R & Leptin, M (2000) Fibroblast growth factor receptor-dependent morphogenesis of the Drosophila mesoderm. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 891-5 PubMed GONUTS page
  6. 6.0 6.1 Zelzer, E & Shilo, BZ (2000) Cell fate choices in Drosophila tracheal morphogenesis. Bioessays 22 219-26 PubMed GONUTS page
  7. Ghabrial, A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu. Rev. Cell Dev. Biol. 19 623-47 PubMed GONUTS page
  8. Guillemin, K et al. (1996) The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system. Development 122 1353-62 PubMed GONUTS page
  9. Montagne, J et al. (1996) The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered. Development 122 2589-97 PubMed GONUTS page
  10. Prout, M et al. (1997) Autosomal mutations affecting adhesion between wing surfaces in Drosophila melanogaster. Genetics 146 275-85 PubMed GONUTS page
  11. 11.0 11.1 Milán, M & Cohen, SM (2000) Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control? Dev. Biol. 217 1-9 PubMed GONUTS page
  12. Tyler, D & Baker, NE (2003) Size isn't everything. Bioessays 25 5-8 PubMed GONUTS page
  13. De Celis, JF (2003) Pattern formation in the Drosophila wing: The development of the veins. Bioessays 25 443-51 PubMed GONUTS page
  14. Dworkin, I & Gibson, G (2006) Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. Genetics 173 1417-31 PubMed GONUTS page
  15. Thran, J et al. (2013) Serum response factor-mediated gene regulation in a Drosophila visual working memory. Curr. Biol. 23 1756-63 PubMed GONUTS page
  16. Donlea, JM et al. (2009) Use-dependent plasticity in clock neurons regulates sleep need in Drosophila. Science 324 105-8 PubMed GONUTS page
  17. Affolter, M & Shilo, BZ (2000) Genetic control of branching morphogenesis during Drosophila tracheal development. Curr. Opin. Cell Biol. 12 731-5 PubMed GONUTS page
  18. Uv, A et al. (2003) Drosophila tracheal morphogenesis: intricate cellular solutions to basic plumbing problems. Trends Cell Biol. 13 301-9 PubMed GONUTS page