DROME:SGG

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	sgg (synonyms: gsk3, zw3)
Protein Name(s)	Protein kinase shaggy Protein zeste-white 3
External Links
UniProt	P18431
EMBL	X70862 X70863 X70864 X70865 X70866 X53332 AE014298 AE014298 AE014298 AE014298 AL024485 AL034544 AL121804 AL024485 AL121804 AL024485 AY122193 AY119664 X54005 X54006
PIR	S35325 S35327 S35328
RefSeq	NP_476714.1 NP_476715.1 NP_476716.2 NP_599105.1 NP_726822.1 NP_726823.1 NP_996335.1 NP_996336.1 NP_996337.1 NP_996338.1
UniGene	Dm.7795
ProteinModelPortal	P18431
SMR	P18431
BioGrid	57779
DIP	DIP-39170N
IntAct	P18431
STRING	7227.FBpp0304140
iPTMnet	P18431
PaxDb	P18431
PRIDE	P18431
EnsemblMetazoa	FBtr0070466 FBtr0070468 FBtr0070469 FBtr0070470 FBtr0070472 FBtr0070473
GeneID	31248
CTD	31248
FlyBase	FBgn0003371
eggNOG	KOG0658 COG0515
GeneTree	ENSGT00520000055635
InParanoid	P18431
OrthoDB	EOG7TF78V
BRENDA	2.7.11.26
Reactome	R-DME-195253 R-DME-196299 R-DME-3371453 R-DME-4641262 R-DME-5610785
SignaLink	P18431
ChiTaRS	sgg
GenomeRNAi	31248
NextBio	772634
PRO	PR:P18431
Proteomes	UP000000803
Bgee	P18431
Genevisible	P18431
GO	GO:0030424 GO:0005938 GO:0030054 GO:0005813 GO:0005737 GO:0005829 GO:0035324 GO:0045169 GO:0072686 GO:0031594 GO:0005654 GO:0005634 GO:0005524 GO:0016301 GO:0004672 GO:0004674 GO:0008407 GO:0035293 GO:0007623 GO:0009649 GO:0003382 GO:0090163 GO:0007143 GO:0046959 GO:0007507 GO:0045475 GO:0043508 GO:0045879 GO:0045886 GO:0030178 GO:0007219 GO:0008355 GO:0048477 GO:0030707 GO:0045842 GO:0032436 GO:0045732 GO:0006468 GO:0030589 GO:0070884 GO:0042752 GO:0045610 GO:0070507 GO:0042306 GO:0030162 GO:0072347 GO:0007622 GO:0007367 GO:0007423 GO:0035019 GO:0007051 GO:0051124 GO:0035309 GO:0016055
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045886	negative regulation of synaptic growth at neuromuscular junction	PMID:25764078^[1]	ECO:0000316		UniProtKB:P91634	P		Figure 3 shows negative regulation of synapses in the larval Drosophila Neuromuscular junction regardless of the presence of upstream regulator PI3k. This is noted as a study of NMJ in the beginning of the discussion.	complete CACAO 11246
part_of	GO:0072686	mitotic spindle	PMID:16570248^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070884	regulation of calcineurin-NFAT signaling cascade	PMID:22421435^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0007143)	Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:15269269^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035324	female germline ring canal	PMID:16570248^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	PMID:15269269^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030589	pseudocleavage involved in syncytial blastoderm formation	PMID:16570248^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:15269269^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:16570248^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15691767^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16570248^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15691767^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:25294944^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:25294944^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007143	female meiotic nuclear division	PMID:22421435^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:19364825^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:19364825^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035293	chitin-based larval cuticle pattern formation	PMID:19737741^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090163	establishment of epithelial cell planar polarity	PMID:21483653^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003382	epithelial cell morphogenesis	PMID:21483653^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0261854	P		Seeded From UniProt	complete
involved_in	GO:0003382	epithelial cell morphogenesis	PMID:21483653^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090163	establishment of epithelial cell planar polarity	PMID:21483653^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0261854	P		Seeded From UniProt	complete
part_of	GO:0045169	fusome	PMID:18355804^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0072347	response to anesthetic	PMID:19863272^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045886	negative regulation of synaptic growth at neuromuscular junction	PMID:18832361^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043508	negative regulation of JUN kinase activity	PMID:18832361^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:19029800^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007051	spindle organization	PMID:19029800^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	PMID:19029800^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:19029800^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19029800^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19029800^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	PMID:19029800^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046959	habituation	PMID:17360579^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008355	olfactory learning	PMID:17360579^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:17360579^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022416	chaeta development	PMID:16222340^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16222340^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(FB:FBgn0000117)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16326393^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035309	wing and notum subfield formation	PMID:16414040^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030707	ovarian follicle cell development	PMID:16542414^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009649	entrainment of circadian clock	PMID:15996552^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051124	synaptic growth at neuromuscular junction	PMID:15269269^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	PMID:12783796^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:12783796^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045879	negative regulation of smoothened signaling pathway	PMID:11912487^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11955435^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030162	regulation of proteolysis	PMID:11955435^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045879	negative regulation of smoothened signaling pathway	PMID:11955435^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11955435^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:11715043^[23]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008407	chaeta morphogenesis	PMID:11715043^[23]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:11440719^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007367	segment polarity determination	PMID:2570722^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:14966281^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11912487^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(FB:FBgn0004859) part_of:(GO:0045879)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11912487^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11927557^[27]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(FB:FBgn0000117)	Seeded From UniProt	complete
involved_in	GO:0035293	chitin-based larval cuticle pattern formation	PMID:9630748^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:9630748^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:7529201^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(FB:FBgn0000117)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:14966281^[26]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(FB:FBgn0000117) part_of:(GO:0090090) positively_regulates:(GO:0043161)\|has_direct_input(FB:FBgn0000499)	Seeded From UniProt	complete
involved_in	GO:0007367	segment polarity determination	PMID:12636921^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:12636921^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000117	P		Seeded From UniProt	complete
involved_in	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	PMID:21628596^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21628596^[31]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(FB:FBgn0000117)	Seeded From UniProt	complete
involved_in	GO:0008587	imaginal disc-derived wing margin morphogenesis	PMID:8162860^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:8162860^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:15024404^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000117	P		Seeded From UniProt	complete
involved_in	GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process	PMID:21951762^[34]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(FB:FBgn0262656)	Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:21951762^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR033573	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	Reactome:R-DME-432626	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-DME-209118	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-DME-881988 Reactome:R-DME-432559 Reactome:R-DME-209331 Reactome:R-DME-209293 Reactome:R-DME-209278 Reactome:R-DME-209224 Reactome:R-DME-209196 Reactome:R-DME-209187 Reactome:R-DME-209172 Reactome:R-DME-209168 Reactome:R-DME-209134 Reactome:R-DME-209120 Reactome:R-DME-209109 Reactome:R-DME-209102 Reactome:R-DME-209097 Reactome:R-DME-209094 Reactome:R-DME-209081 Reactome:R-DME-209075	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-DME-881988 Reactome:R-DME-209172 Reactome:R-DME-209118 Reactome:R-DME-209109	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042306	regulation of protein import into nucleus	PMID:12486701^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007622	rhythmic behavior	PMID:12486701^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:10973066^[36]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0007367	segment polarity determination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0709	P		Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0469	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Cuesto, G et al. (2015) GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS ONE 10 e0118475 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Bobinnec, Y et al. (2006) Shaggy/GSK-3beta kinase localizes to the centrosome and to specialized cytoskeletal structures in Drosophila. Cell Motil. Cytoskeleton 63 313-20 PubMed GONUTS page
↑ ^3.0 ^3.1 Takeo, S et al. (2012) Shaggy/glycogen synthase kinase 3β and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis. Proc. Natl. Acad. Sci. U.S.A. 109 6382-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Franco, B et al. (2004) Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila. J. Neurosci. 24 6573-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Zhang, W et al. (2005) Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev. Cell 8 267-78 PubMed GONUTS page
↑ ^6.0 ^6.1 Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page
↑ ^7.0 ^7.1 Galletti, M et al. (2009) Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases. Mol. Cell. Biol. 29 3424-34 PubMed GONUTS page
↑ Kaplan, NA et al. (2009) Epithelial polarity: interactions between junctions and apical-basal machinery. Genetics 183 897-904 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Kaplan, NA et al. (2011) Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis. PLoS ONE 6 e18616 PubMed GONUTS page
↑ Lighthouse, DV et al. (2008) New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev. Biol. 317 59-71 PubMed GONUTS page
↑ Campbell, JL et al. (2009) Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. J. Neurogenet. 23 412-21 PubMed GONUTS page
↑ ^12.0 ^12.1 Franciscovich, AL et al. (2008) Overexpression screen in Drosophila identifies neuronal roles of GSK-3 beta/shaggy as a regulator of AP-1-dependent developmental plasticity. Genetics 180 2057-71 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Wojcik, EJ (2008) A mitotic role for GSK-3beta kinase in Drosophila. Cell Cycle 7 3699-708 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Wolf, FW et al. (2007) GSK-3/Shaggy regulates olfactory habituation in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 104 4653-7 PubMed GONUTS page
↑ ^15.0 ^15.1 Kanuka, H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 24 3793-806 PubMed GONUTS page
↑ Jia, J et al. (2005) Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev. Cell 9 819-30 PubMed GONUTS page
↑ Mohit, P et al. (2006) Modulation of AP and DV signaling pathways by the homeotic gene Ultrabithorax during haltere development in Drosophila. Dev. Biol. 291 356-67 PubMed GONUTS page
↑ Jordan, KC et al. (2006) Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. BMC Dev. Biol. 6 16 PubMed GONUTS page
↑ Yuan, Q et al. (2005) Serotonin modulates circadian entrainment in Drosophila. Neuron 47 115-27 PubMed GONUTS page
↑ ^20.0 ^20.1 Song, X & Xie, T (2003) Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila. Development 130 3259-68 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Jia, J et al. (2002) Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 416 548-52 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Price, MA & Kalderon, D (2002) Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell 108 823-35 PubMed GONUTS page
↑ ^23.0 ^23.1 Sokolowski, MB (2001) Drosophila: genetics meets behaviour. Nat. Rev. Genet. 2 879-90 PubMed GONUTS page
↑ Martinek, S et al. (2001) A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell 105 769-79 PubMed GONUTS page
↑ Perrimon, N & Smouse, D (1989) Multiple functions of a Drosophila homeotic gene, zeste-white 3, during segmentation and neurogenesis. Dev. Biol. 135 287-305 PubMed GONUTS page
↑ ^26.0 ^26.1 Matsubayashi, H et al. (2004) Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Mol. Cell. Biol. 24 2012-24 PubMed GONUTS page
↑ Yanagawa, S et al. (2002) Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. EMBO J. 21 1733-42 PubMed GONUTS page
↑ ^28.0 ^28.1 Steitz, MC et al. (1998) Overexpression of zeste white 3 blocks wingless signaling in the Drosophila embryonic midgut. Dev. Biol. 197 218-33 PubMed GONUTS page
↑ Peifer, M et al. (1994) Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase. Dev. Biol. 166 543-56 PubMed GONUTS page
↑ ^30.0 ^30.1 Tolwinski, NS et al. (2003) Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. Dev. Cell 4 407-18 PubMed GONUTS page
↑ ^31.0 ^31.1 Swarup, S & Verheyen, EM (2011) Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling. Proc. Natl. Acad. Sci. U.S.A. 108 9887-92 PubMed GONUTS page
↑ ^32.0 ^32.1 Couso, JP et al. (1994) The wingless signalling pathway and the patterning of the wing margin in Drosophila. Development 120 621-36 PubMed GONUTS page
↑ Tolwinski, NS & Wieschaus, E (2004) A nuclear function for armadillo/beta-catenin. PLoS Biol. 2 E95 PubMed GONUTS page
↑ ^34.0 ^34.1 Parisi, F et al. (2011) Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo. BMC Biol. 9 65 PubMed GONUTS page
↑ ^35.0 ^35.1 Stanewsky, R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J. Neurobiol. 54 111-47 PubMed GONUTS page
↑ Chen, JN & Fishman, MC (2000) Genetics of heart development. Trends Genet. 16 383-8 PubMed GONUTS page

[PMID:25764078-1] Cuesto, G et al. (2015) GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS ONE 10 e0118475 PubMed GONUTS page

[PMID:16570248-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Bobinnec, Y et al. (2006) Shaggy/GSK-3beta kinase localizes to the centrosome and to specialized cytoskeletal structures in Drosophila. Cell Motil. Cytoskeleton 63 313-20 PubMed GONUTS page

[PMID:22421435-3] 3.0 ^3.1 Takeo, S et al. (2012) Shaggy/glycogen synthase kinase 3β and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis. Proc. Natl. Acad. Sci. U.S.A. 109 6382-9 PubMed GONUTS page

[PMID:15269269-4] 4.0 ^4.1 ^4.2 ^4.3 Franco, B et al. (2004) Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila. J. Neurosci. 24 6573-7 PubMed GONUTS page

[PMID:15691767-5] 5.0 ^5.1 Zhang, W et al. (2005) Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev. Cell 8 267-78 PubMed GONUTS page

[PMID:25294944-6] 6.0 ^6.1 Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page

[PMID:19364825-7] 7.0 ^7.1 Galletti, M et al. (2009) Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases. Mol. Cell. Biol. 29 3424-34 PubMed GONUTS page

[PMID:19737741-8] Kaplan, NA et al. (2009) Epithelial polarity: interactions between junctions and apical-basal machinery. Genetics 183 897-904 PubMed GONUTS page

[PMID:21483653-9] 9.0 ^9.1 ^9.2 ^9.3 Kaplan, NA et al. (2011) Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis. PLoS ONE 6 e18616 PubMed GONUTS page

[PMID:18355804-10] Lighthouse, DV et al. (2008) New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev. Biol. 317 59-71 PubMed GONUTS page

[PMID:19863272-11] Campbell, JL et al. (2009) Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. J. Neurogenet. 23 412-21 PubMed GONUTS page

[PMID:18832361-12] 12.0 ^12.1 Franciscovich, AL et al. (2008) Overexpression screen in Drosophila identifies neuronal roles of GSK-3 beta/shaggy as a regulator of AP-1-dependent developmental plasticity. Genetics 180 2057-71 PubMed GONUTS page

[PMID:19029800-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Wojcik, EJ (2008) A mitotic role for GSK-3beta kinase in Drosophila. Cell Cycle 7 3699-708 PubMed GONUTS page

[PMID:17360579-14] 14.0 ^14.1 ^14.2 Wolf, FW et al. (2007) GSK-3/Shaggy regulates olfactory habituation in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 104 4653-7 PubMed GONUTS page

[PMID:16222340-15] 15.0 ^15.1 Kanuka, H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 24 3793-806 PubMed GONUTS page

[PMID:16326393-16] Jia, J et al. (2005) Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev. Cell 9 819-30 PubMed GONUTS page

[PMID:16414040-17] Mohit, P et al. (2006) Modulation of AP and DV signaling pathways by the homeotic gene Ultrabithorax during haltere development in Drosophila. Dev. Biol. 291 356-67 PubMed GONUTS page

[PMID:16542414-18] Jordan, KC et al. (2006) Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. BMC Dev. Biol. 6 16 PubMed GONUTS page

[PMID:15996552-19] Yuan, Q et al. (2005) Serotonin modulates circadian entrainment in Drosophila. Neuron 47 115-27 PubMed GONUTS page

[PMID:12783796-20] 20.0 ^20.1 Song, X & Xie, T (2003) Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila. Development 130 3259-68 PubMed GONUTS page

[PMID:11912487-21] 21.0 ^21.1 ^21.2 Jia, J et al. (2002) Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 416 548-52 PubMed GONUTS page

[PMID:11955435-22] 22.0 ^22.1 ^22.2 ^22.3 Price, MA & Kalderon, D (2002) Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell 108 823-35 PubMed GONUTS page

[PMID:11715043-23] 23.0 ^23.1 Sokolowski, MB (2001) Drosophila: genetics meets behaviour. Nat. Rev. Genet. 2 879-90 PubMed GONUTS page

[PMID:11440719-24] Martinek, S et al. (2001) A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell 105 769-79 PubMed GONUTS page

[PMID:2570722-25] Perrimon, N & Smouse, D (1989) Multiple functions of a Drosophila homeotic gene, zeste-white 3, during segmentation and neurogenesis. Dev. Biol. 135 287-305 PubMed GONUTS page

[PMID:14966281-26] 26.0 ^26.1 Matsubayashi, H et al. (2004) Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Mol. Cell. Biol. 24 2012-24 PubMed GONUTS page

[PMID:11927557-27] Yanagawa, S et al. (2002) Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. EMBO J. 21 1733-42 PubMed GONUTS page

[PMID:9630748-28] 28.0 ^28.1 Steitz, MC et al. (1998) Overexpression of zeste white 3 blocks wingless signaling in the Drosophila embryonic midgut. Dev. Biol. 197 218-33 PubMed GONUTS page

[PMID:7529201-29] Peifer, M et al. (1994) Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase. Dev. Biol. 166 543-56 PubMed GONUTS page

[PMID:12636921-30] 30.0 ^30.1 Tolwinski, NS et al. (2003) Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. Dev. Cell 4 407-18 PubMed GONUTS page

[PMID:21628596-31] 31.0 ^31.1 Swarup, S & Verheyen, EM (2011) Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling. Proc. Natl. Acad. Sci. U.S.A. 108 9887-92 PubMed GONUTS page

[PMID:8162860-32] 32.0 ^32.1 Couso, JP et al. (1994) The wingless signalling pathway and the patterning of the wing margin in Drosophila. Development 120 621-36 PubMed GONUTS page

[PMID:15024404-33] Tolwinski, NS & Wieschaus, E (2004) A nuclear function for armadillo/beta-catenin. PLoS Biol. 2 E95 PubMed GONUTS page

[PMID:21951762-34] 34.0 ^34.1 Parisi, F et al. (2011) Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo. BMC Biol. 9 65 PubMed GONUTS page

[PMID:12486701-35] 35.0 ^35.1 Stanewsky, R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J. Neurobiol. 54 111-47 PubMed GONUTS page

[PMID:10973066-36] Chen, JN & Fishman, MC (2000) Genetics of heart development. Trends Genet. 16 383-8 PubMed GONUTS page

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