PMID:15996552

Citation	Yuan, Q, Lin, F, Zheng, X and Sehgal, A (2005) Serotonin modulates circadian entrainment in Drosophila. Neuron 47:115-27
Abstract	Entrainment of the Drosophila circadian clock to light involves the light-induced degradation of the clock protein timeless (TIM). We show here that this entrainment mechanism is inhibited by serotonin, acting through the Drosophila serotonin receptor 1B (d5-HT1B). d5-HT1B is expressed in clock neurons, and alterations of its levels affect molecular and behavioral responses of the clock to light. Effects of d5-HT1B are synergistic with a mutation in the circadian photoreceptor cryptochrome (CRY) and are mediated by SHAGGY (SGG), Drosophila glycogen synthase kinase 3beta (GSK3beta), which phosphorylates TIM. Levels of serotonin are decreased in flies maintained in extended constant darkness, suggesting that modulation of the clock by serotonin may vary under different environmental conditions. These data identify a molecular connection between serotonin signaling and the central clock component TIM and suggest a homeostatic mechanism for the regulation of circadian photosensitivity in Drosophila.
Links	PubMed Online version:10.1016/j.neuron.2005.05.027
Keywords	5-Hydroxytryptophan/pharmacology; Animals; Animals, Genetically Modified; Brain Chemistry; Circadian Rhythm/drug effects; Circadian Rhythm/genetics; Circadian Rhythm/physiology; Citalopram/pharmacology; Drosophila/physiology; Fluoxetine/pharmacology; Glycogen Synthase Kinase 3/physiology; Immunohistochemistry; Light; Mutation/physiology; Phosphorylation; RNA Interference; Receptor, Serotonin, 5-HT1A/drug effects; Receptor, Serotonin, 5-HT1B/drug effects; Serotonin/metabolism; Serotonin/physiology; Serotonin Uptake Inhibitors/pharmacology
edit table

Annotations

Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
edit table

References

See Help:References for how to manage references in GONUTS.