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DROME:RCOR

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) CoRest
Protein Name(s) REST corepressor

CoREST

External Links
UniProt Q59E36
EMBL AE014298
AE014298
AE014298
AE014298
AE014298
BT023817
AY060226
AY118507
RefSeq NP_001014752.2
NP_001014753.1
NP_001014754.1
NP_001014755.1
NP_001014756.1
UniGene Dm.4085
ProteinModelPortal Q59E36
SMR Q59E36
BioGrid 59243
IntAct Q59E36
MINT MINT-1651349
PaxDb Q59E36
PRIDE Q59E36
GeneID 32941
KEGG dme:Dmel_CG42687
UCSC CG33525-RA
CTD 32941
FlyBase FBgn0261573
eggNOG NOG326181
InParanoid Q59E36
OrthoDB EOG7MWGX1
GenomeRNAi 32941
NextBio 781152
Proteomes UP000000803
GO GO:0005634
GO:0017053
GO:0003682
GO:0003677
GO:0003714
GO:0016568
GO:0061086
GO:2000619
GO:0045892
GO:0045747
GO:0007221
GO:0006351
InterPro IPR000949
IPR009057
IPR001005
IPR017884
Pfam PF01448
SMART SM00717
SUPFAM SSF46689
PROSITE PS51156
PS51293

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:15306652[1]

ISS: Inferred from Sequence or Structural Similarity

HGNC:17441

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009057

F

Seeded From UniProt

complete

GO:0003682

chromatin binding

PMID:15306652[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003714

transcription corepressor activity

PMID:15306652[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15306652[1]

IPI: Inferred from Physical Interaction

FB:FBgn0003870

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15306652[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VW97

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16763555[2]

IPI: Inferred from Physical Interaction

FB:FBgn0015371

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:15306652[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0007221

positive regulation of transcription of Notch receptor target

PMID:22331351[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016568

chromatin modification

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

GO:0017053

transcriptional repressor complex

PMID:15306652[1]

IPI: Inferred from Physical Interaction

FB:FBgn0015805

C

Seeded From UniProt

complete

GO:0017053

transcriptional repressor complex

PMID:15306652[1]

IPI: Inferred from Physical Interaction

FB:FBgn0260397

C

Seeded From UniProt

complete

GO:0045747

positive regulation of Notch signaling pathway

PMID:22331351[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045892

negative regulation of transcription, DNA-templated

PMID:15306652[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0061086

negative regulation of histone H3-K27 methylation

PMID:22331351[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000619

negative regulation of histone H4-K16 acetylation

PMID:22331351[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Dallman, JE et al. (2004) A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation. J. Neurosci. 24 7186-93 PubMed GONUTS page
  2. Tsuda, L et al. (2006) An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila. EMBO J. 25 3191-202 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Domanitskaya, E & Schüpbach, T (2012) CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster. J. Cell. Sci. 125 399-410 PubMed GONUTS page