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DROME:Q9VV74
Contents
Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
Gene Name(s) | Smn | |
Protein Name(s) | LD23602p
Survival motor neuron protein SMN Survival motor neuron, isoform A Survival motor neuron, isoform B | |
External Links | ||
UniProt | Q9VV74 | |
EMBL | AE014296 AF296281 AY058529 AE014296 | |
RefSeq | NP_001261954.1 NP_524112.1 | |
UniGene | Dm.2679 | |
PDB | 1VU2 1VU3 4F77 | |
PDBsum | 1VU2 1VU3 4F77 | |
DIP | DIP-18223N | |
MINT | MINT-750365 | |
STRING | 7227.FBpp0075153 | |
EnsemblMetazoa | FBtr0075395 FBtr0329921 | |
GeneID | 39844 | |
KEGG | dme:Dmel_CG16725 | |
UCSC | CG16725-RA | |
CTD | 39844 | |
FlyBase | FBgn0036641 | |
eggNOG | NOG296671 | |
GeneTree | ENSGT00560000077236 | |
InParanoid | Q9VV74 | |
KO | K13129 | |
OMA | SAMLMSW | |
OrthoDB | EOG473N7S | |
GenomeRNAi | 39844 | |
NextBio | 815685 | |
PRO | PR:Q9VV74 | |
GO | GO:0015030 GO:0071254 GO:0031594 GO:0030018 GO:0003723 GO:0007528 GO:0030240 GO:0000387 GO:0035154 | |
InterPro | IPR010304 IPR002999 | |
Pfam | PF06003 | |
SMART | SM00333 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0035209 |
pupal development |
ECO:0000315 |
P |
Fig 8F. Using daughterless-GAL4 (da-GAL4) and a functional SMN-YFP transgene: the da-GAL4; SMN-YFP larvae had irregular pupation patterns with many larvae pupated earlier than the da-GAL4 controls. |
complete | |||||
GO:0007419 |
ventral cord development |
ECO:0000315 |
P |
Fig 8(A-C). At 3 and 4 days after hatching the ventral nerve cord of the larvae were measured. da-GAL4; SMN-YFP CNS are larger than control at each time point. |
complete | |||||
involved_in |
GO:1990194 |
cytoplasmic U snRNP body assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0097504 |
Gemini of coiled bodies |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000026) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097113 |
AMPA glutamate receptor clustering |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072553 |
terminal button organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072089 |
stem cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0071254 |
cytoplasmic U snRNP body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000026)|part_of:(CL:0000023) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060079 |
excitatory postsynaptic potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060079 |
excitatory postsynaptic potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060079 |
excitatory postsynaptic potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051276 |
chromosome organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000026)|occurs_in:(CL:0000023)|occurs_in:(CL:0000477) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048863 |
stem cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0048601 |
oocyte morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045175 |
basal protein localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0034730 |
SmD-containing SMN-Sm protein complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0034718 |
SMN-Gemin2 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0033962 |
cytoplasmic mRNA processing body assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032224 |
positive regulation of synaptic transmission, cholinergic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032224 |
positive regulation of synaptic transmission, cholinergic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0017145 |
stem cell division |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0009792 |
embryo development ending in birth or egg hatching |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008345 |
larval locomotory behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008345 |
larval locomotory behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008345 |
larval locomotory behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008345 |
larval locomotory behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007528 |
neuromuscular junction development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007417 |
central nervous system development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007274 |
neuromuscular synaptic transmission |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007274 |
neuromuscular synaptic transmission |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000477)|part_of:(CL:0000022)|part_of:(CL:0000722) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000031)|part_of:(UBERON:0000473) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002164 |
larval development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000398 |
mRNA splicing, via spliceosome |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:Q9VX39) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000398 |
mRNA splicing, via spliceosome |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000387 |
spliceosomal snRNP assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0032797 |
SMN complex |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0011802 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035154 |
terminal cell fate specification, open tracheal system |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000387 |
spliceosomal snRNP assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0071254 |
cytoplasmic U snRNP body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0022618 |
ribonucleoprotein complex assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0015030 |
Cajal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031594 |
neuromuscular junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007528 |
neuromuscular junction development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0015030 |
Cajal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0015030 |
Cajal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0071254 |
cytoplasmic U snRNP body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000387 |
spliceosomal snRNP assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030018 |
Z disc |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031674 |
I band |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030240 |
skeletal muscle thin filament assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051393 |
alpha-actinin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
FB:FBgn0000667 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0015030 |
Cajal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0097113 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098794 |
postsynapse |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0060079 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098794 |
postsynapse |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0060079 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098794 |
postsynapse |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0060079 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005681 |
spliceosomal complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031674 |
I band |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0097504 |
Gemini of coiled bodies |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030018 |
Z disc |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Grice, SJ & Liu, JL (2011) Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in Drosophila. PLoS Genet. 7 e1002030 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Lee, L et al. (2009) The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway. Dev. Biol. 332 142-55 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Chan, YB et al. (2003) Neuromuscular defects in a Drosophila survival motor neuron gene mutant. Hum. Mol. Genet. 12 1367-76 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Lotti, F et al. (2012) An SMN-dependent U12 splicing event essential for motor circuit function. Cell 151 440-54 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Imlach, WL et al. (2012) SMN is required for sensory-motor circuit function in Drosophila. Cell 151 427-39 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Kroiss, M et al. (2008) Evolution of an RNP assembly system: a minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 105 10045-50 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Praveen, K et al. (2012) A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep 1 624-31 PubMed GONUTS page
- ↑ Hua, Y & Zhou, J (2004) Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress. Biochem. Biophys. Res. Commun. 314 268-76 PubMed GONUTS page
- ↑ Giot, L et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302 1727-36 PubMed GONUTS page
- ↑ Borg, RM et al. (2015) Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila. PLoS ONE 10 e0130974 PubMed GONUTS page
- ↑ Ruiz, OE et al. (2012) Drosophila Zpr1 (Zinc finger protein 1) is required downstream of both EGFR and FGFR signaling in tracheal subcellular lumen formation. PLoS ONE 7 e45649 PubMed GONUTS page
- ↑ 12.0 12.1 Buckingham, M & Liu, JL (2011) U bodies respond to nutrient stress in Drosophila. Exp. Cell Res. 317 2835-44 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Shpargel, KB et al. (2009) Gemin3 is an essential gene required for larval motor function and pupation in Drosophila. Mol. Biol. Cell 20 90-101 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Chang, HC et al. (2008) Modeling spinal muscular atrophy in Drosophila. PLoS ONE 3 e3209 PubMed GONUTS page
- ↑ 15.0 15.1 Liu, JL & Gall, JG (2007) U bodies are cytoplasmic structures that contain uridine-rich small nuclear ribonucleoproteins and associate with P bodies. Proc. Natl. Acad. Sci. U.S.A. 104 11655-9 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 16.4 16.5 Rajendra, TK et al. (2007) A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle. J. Cell Biol. 176 831-41 PubMed GONUTS page
- ↑ 17.0 17.1 Liu, JL et al. (2006) The Drosophila melanogaster Cajal body. J. Cell Biol. 172 875-84 PubMed GONUTS page
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- GO:0030240 ! skeletal muscle thin filament assembly
- GO:0034730 ! SmD-containing SMN-Sm protein complex
- GO:0034718 ! SMN-Gemin2 complex
- GO:0032797 ! SMN complex
- Sophophora
- GO:0005681 ! spliceosomal complex
- GO:0000387 ! spliceosomal snRNP assembly
- GO:0048863 ! stem cell differentiation
- GO:0017145 ! stem cell division
- GO:0072089 ! stem cell proliferation
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