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DROME:Q9VV74

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Smn
Protein Name(s) LD23602p

Survival motor neuron protein SMN Survival motor neuron, isoform A Survival motor neuron, isoform B

External Links
UniProt Q9VV74
EMBL AE014296
AF296281
AY058529
AE014296
RefSeq NP_001261954.1
NP_524112.1
UniGene Dm.2679
PDB 1VU2
1VU3
4F77
PDBsum 1VU2
1VU3
4F77
DIP DIP-18223N
MINT MINT-750365
STRING 7227.FBpp0075153
EnsemblMetazoa FBtr0075395
FBtr0329921
GeneID 39844
KEGG dme:Dmel_CG16725
UCSC CG16725-RA
CTD 39844
FlyBase FBgn0036641
eggNOG NOG296671
GeneTree ENSGT00560000077236
InParanoid Q9VV74
KO K13129
OMA SAMLMSW
OrthoDB EOG473N7S
GenomeRNAi 39844
NextBio 815685
PRO PR:Q9VV74
GO GO:0015030
GO:0071254
GO:0031594
GO:0030018
GO:0003723
GO:0007528
GO:0030240
GO:0000387
GO:0035154
InterPro IPR010304
IPR002999
Pfam PF06003
SMART SM00333

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0035209

pupal development

PMID:21490958[1]

IMP: Inferred from Mutant Phenotype

P

Fig 8F.

Using daughterless-GAL4 (da-GAL4) and a functional SMN-YFP transgene: the da-GAL4; SMN-YFP larvae had irregular pupation patterns with many larvae pupated earlier than the da-GAL4 controls.

complete

GO:0007419

ventral cord development

PMID:21490958[1]

IMP: Inferred from Mutant Phenotype

P

Fig 8(A-C).

At 3 and 4 days after hatching the ventral nerve cord of the larvae were measured. da-GAL4; SMN-YFP CNS are larger than control at each time point.

complete

GO:0000387

spliceosomal snRNP assembly

PMID:17353360[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002999

F

complete

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010304

F

complete

GO:0005515

protein binding

PMID:14605208[3]

IPI: Inferred from Physical Interaction

UniProtKB:P48554

F

complete

GO:0005515

protein binding

PMID:14605208[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q8IMM5

F

complete

GO:0005515

protein binding

PMID:14605208[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9V3C4

F

complete

GO:0005515

protein binding

PMID:14605208[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VI58

F

complete

GO:0005515

protein binding

PMID:14605208[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VVX0

F

complete

GO:0005515

protein binding

PMID:14715275[4]

IPI: Inferred from Physical Interaction

UniProtKB:P63162

F

complete

GO:0005515

protein binding

PMID:14715275[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q2MGL3

F

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010304

C

complete

GO:0005634

nucleus

PMID:17353360[2]

IDA: Inferred from Direct Assay

C

complete

GO:0005737

cytoplasm

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010304

C

complete

GO:0005737

cytoplasm

PMID:16533947[5]

IDA: Inferred from Direct Assay

C

complete

GO:0005737

cytoplasm

PMID:18923150[6]

IDA: Inferred from Direct Assay

C

complete

GO:0006397

mRNA processing

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010304

P

complete

GO:0007528

neuromuscular junction development

PMID:18791638[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0015030

Cajal body

PMID:16533947[5]

IDA: Inferred from Direct Assay

C

complete

GO:0015030

Cajal body

PMID:17595295[8]

IDA: Inferred from Direct Assay

C

complete

GO:0015030

Cajal body

PMID:18791638[7]

IDA: Inferred from Direct Assay

C

complete

GO:0015030

Cajal body

PMID:18923150[6]

IDA: Inferred from Direct Assay

C

complete

GO:0022618

ribonucleoprotein complex assembly

PMID:18923150[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0030018

Z disc

PMID:17353360[2]

IDA: Inferred from Direct Assay

C

complete

GO:0030240

skeletal muscle thin filament assembly

PMID:17353360[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0031594

neuromuscular junction

PMID:18791638[7]

IDA: Inferred from Direct Assay

C

complete

GO:0031674

I band

PMID:17353360[2]

IDA: Inferred from Direct Assay

C

complete

GO:0042802

identical protein binding

PMID:14715275[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VV74

F

complete

GO:0000245

spliceosomal complex assembly

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000292279

P

Seeded From UniProt

complete

GO:0051393

alpha-actinin binding

PMID:17353360[2]

IPI: Inferred from Physical Interaction

FB:FBgn0000667

F

complete

GO:0000387

spliceosomal snRNP assembly

PMID:17353360[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071254

cytoplasmic U snRNP body

PMID:17595295[8]

IDA: Inferred from Direct Assay

C

complete

GO:0000387

spliceosomal snRNP assembly

PMID:18621711[9]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0000387

spliceosomal snRNP assembly

PMID:22813737[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000398

mRNA splicing, via spliceosome

PMID:22813737[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000398

mRNA splicing, via spliceosome

PMID:23063131[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0002164

larval development

PMID:12783845[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010304

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14715275[4]

IPI: Inferred from Physical Interaction

UniProtKB:P63162

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14715275[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q2MGL3

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010304

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:17353360[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005681

spliceosomal complex

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000292279

C

Seeded From UniProt

complete

GO:0005681

spliceosomal complex

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0747

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010304

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:16533947[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:18923150[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:19464282[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:21490958[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:21939654[14]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006397

mRNA processing

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010304

P

Seeded From UniProt

complete

GO:0006397

mRNA processing

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

GO:0007274

neuromuscular synaptic transmission

PMID:23063130[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007274

neuromuscular synaptic transmission

PMID:23063131[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007417

central nervous system development

PMID:21490958[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007528

neuromuscular junction development

PMID:12783845[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007528

neuromuscular junction development

PMID:18791638[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008345

larval locomotory behavior

PMID:12783845[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008345

larval locomotory behavior

PMID:22813737[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008345

larval locomotory behavior

PMID:23063130[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008345

larval locomotory behavior

PMID:23063131[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008380

RNA splicing

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

GO:0009790

embryo development

PMID:12783845[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0015030

Cajal body

PMID:16533947[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0015030

Cajal body

PMID:17595295[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0015030

Cajal body

PMID:18791638[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0015030

Cajal body

PMID:18923150[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0017145

stem cell division

PMID:21490958[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0022618

ribonucleoprotein complex assembly

PMID:18923150[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030018

Z disc

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0314

C

Seeded From UniProt

complete

GO:0030018

Z disc

PMID:17353360[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030240

skeletal muscle thin filament assembly

PMID:17353360[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031594

neuromuscular junction

PMID:18791638[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0031674

I band

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0478

C

Seeded From UniProt

complete

GO:0031674

I band

PMID:17353360[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0032224

positive regulation of synaptic transmission, cholinergic

PMID:23063130[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0032224

positive regulation of synaptic transmission, cholinergic

PMID:23063131[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0033962

cytoplasmic mRNA processing body assembly

PMID:19464282[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034718

SMN-Gemin2 complex

PMID:18621711[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0034730

SmD-containing SMN-Sm protein complex

PMID:18621711[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0035154

terminal cell fate specification, open tracheal system

PMID:23029159[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042802

identical protein binding

PMID:14605208[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VV74

F

Seeded From UniProt

complete

GO:0042802

identical protein binding

PMID:14715275[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VV74

F

Seeded From UniProt

complete

GO:0045175

basal protein localization

PMID:21490958[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048601

oocyte morphogenesis

PMID:12783845[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048863

stem cell differentiation

PMID:21490958[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051276

chromosome organization

PMID:19464282[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051393

alpha-actinin binding

PMID:17353360[2]

IPI: Inferred from Physical Interaction

FB:FBgn0000667

F

Seeded From UniProt

complete

GO:0060079

excitatory postsynaptic potential

PMID:12783845[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060079

excitatory postsynaptic potential

PMID:23063130[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060079

excitatory postsynaptic potential

PMID:23063131[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071254

cytoplasmic U snRNP body

PMID:17595295[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0071254

cytoplasmic U snRNP body

PMID:19464282[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0071254

cytoplasmic U snRNP body

PMID:21939654[14]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0072089

stem cell proliferation

PMID:21490958[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0072553

terminal button organization

PMID:12783845[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0097113

AMPA glutamate receptor clustering

PMID:12783845[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0097504

Gemini of coiled bodies

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0127

C

Seeded From UniProt

complete

GO:0097504

Gemini of coiled bodies

PMID:19464282[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:1990194

cytoplasmic U snRNP body assembly

PMID:19464282[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Grice, SJ & Liu, JL (2011) Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in Drosophila. PLoS Genet. 7 e1002030 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Rajendra, TK et al. (2007) A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle. J. Cell Biol. 176 831-41 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Giot, L et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302 1727-36 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Hua, Y & Zhou, J (2004) Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress. Biochem. Biophys. Res. Commun. 314 268-76 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Liu, JL et al. (2006) The Drosophila melanogaster Cajal body. J. Cell Biol. 172 875-84 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Shpargel, KB et al. (2009) Gemin3 is an essential gene required for larval motor function and pupation in Drosophila. Mol. Biol. Cell 20 90-101 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 Chang, HC et al. (2008) Modeling spinal muscular atrophy in Drosophila. PLoS ONE 3 e3209 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Liu, JL & Gall, JG (2007) U bodies are cytoplasmic structures that contain uridine-rich small nuclear ribonucleoproteins and associate with P bodies. Proc. Natl. Acad. Sci. U.S.A. 104 11655-9 PubMed GONUTS page
  9. 9.0 9.1 9.2 Kroiss, M et al. (2008) Evolution of an RNP assembly system: a minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 105 10045-50 PubMed GONUTS page
  10. 10.0 10.1 10.2 Praveen, K et al. (2012) A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep 1 624-31 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 Lotti, F et al. (2012) An SMN-dependent U12 splicing event essential for motor circuit function. Cell 151 440-54 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 12.4 12.5 12.6 12.7 Chan, YB et al. (2003) Neuromuscular defects in a Drosophila survival motor neuron gene mutant. Hum. Mol. Genet. 12 1367-76 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 13.4 13.5 Lee, L et al. (2009) The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway. Dev. Biol. 332 142-55 PubMed GONUTS page
  14. 14.0 14.1 Buckingham, M & Liu, JL (2011) U bodies respond to nutrient stress in Drosophila. Exp. Cell Res. 317 2835-44 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 Imlach, WL et al. (2012) SMN is required for sensory-motor circuit function in Drosophila. Cell 151 427-39 PubMed GONUTS page
  16. Ruiz, OE et al. (2012) Drosophila Zpr1 (Zinc finger protein 1) is required downstream of both EGFR and FGFR signaling in tracheal subcellular lumen formation. PLoS ONE 7 e45649 PubMed GONUTS page