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DROME:Q9VIE8

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided. (synonyms: mAc (ECO:0000313 with EMBL:CAB93521.1))
Protein Name(s) Aconitase, isoform B (ECO:0000313 with EMBL:AAF53973.2)

Aconitase, isoform D (ECO:0000313 with EMBL:ACZ94316.1) Aconitase, isoform E (ECO:0000313 with EMBL:ABV53697.2) Aconitase, isoform F (ECO:0000313 with EMBL:AHN54633.1) LD24561p (ECO:0000313 with EMBL:AAK93129.1) Mitochondrial aconitase (ECO:0000313 with EMBL:CAB93521.1)

External Links
UniProt Q9VIE8
EMBL AE014134
AY051705
AE014134
AE014134
AE014134
AJ252018
RefSeq NP_001163030.1
NP_524708.1
UniGene Dm.7227
SMR Q9VIE8
IntAct Q9VIE8
MINT MINT-994599
EnsemblMetazoa FBtr0081473
FBtr0300425
GeneID 44149
KEGG dme:Dmel_CG9244
UCSC CG9244-RB
CTD 44149
FlyBase FBgn0010100
GeneTree ENSGT00760000119287
KO K01681
OMA PLKCIIK
PhylomeDB Q9VIE8
Reactome REACT_218888
ChiTaRS Acon
GenomeRNAi 44149
NextBio 836873
PRO PR:Q9VIE8
Proteomes UP000000803
GO GO:0005811
GO:0005739
GO:0051539
GO:0003994
GO:0006099
Gene3D 3.20.19.10
3.30.499.10
3.40.1060.10
InterPro IPR015931
IPR015937
IPR001030
IPR015928
IPR015932
IPR018136
IPR006248
IPR000573
PANTHER PTHR11670
Pfam PF00330
PF00694
PRINTS PR00415
SUPFAM SSF52016
SSF53732
TIGRFAMs TIGR01340
PROSITE PS00450
PS01244

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

Contributes to

GO:0003994

aconitate hydratase activity

PMID:22493725[1]

ECO:0000314

F

Found in fruit flies and pathogenic to plants; floats in the cytosol of bacteria.

complete
CACAO 10557

enables

GO:0051539

4 iron, 4 sulfur cluster binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
PANTHER:PTN000186533
RGD:621360
UniProtKB:P20004

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010100
PANTHER:PTN000186533
RGD:621360
SGD:S000004295
UniProtKB:Q8ZRS8
UniProtKB:Q99798

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
PANTHER:PTN001705783
SGD:S000004295

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010100
MGI:MGI:87880
PANTHER:PTN000186534
PomBase:SPAC24C9.06c
PomBase:SPBP4H10.15
RGD:621360
UniProtKB:P20004

C

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
MGI:MGI:87880
PANTHER:PTN000186533
RGD:621360
SGD:S000004295
UniProtKB:C8VG90
UniProtKB:P20004
UniProtKB:Q4WLN1
UniProtKB:Q8ZRS8
UniProtKB:Q99798

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:19317464[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:23637640[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

PMID:23438437[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000110

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99798

C

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

GO_REF:0000110

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99798

F

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

PMID:11095759[6]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:16212416[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006248

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006248

P

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006248

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0051536

iron-sulfur cluster binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0411

F

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000040

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000137797

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000137797

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Kirchberg, J et al. (2012) Aconitase B is required for optimal growth of Xanthomonas campestris pv. vesicatoria in pepper plants. PLoS ONE 7 e34941 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
  4. Esposito, G et al. (2013) Aconitase causes iron toxicity in Drosophila pink1 mutants. PLoS Genet. 9 e1003478 PubMed GONUTS page
  5. Cheng, Z et al. (2013) Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency. Biochem. Biophys. Res. Commun. 433 145-50 PubMed GONUTS page
  6. Zou, S et al. (2000) Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 97 13726-31 PubMed GONUTS page
  7. Alonso, J et al. () Characterization of the Drosophila melanogaster mitochondrial proteome. J. Proteome Res. 4 1636-45 PubMed GONUTS page