DROME:Q9U470

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	No Information Provided.
Protein Name(s)	Phosphatase and tensin homolog (ECO:0000313 with EMBL:AAF23236.1)
External Links
UniProt	Q9U470
EMBL	AF201905
ProteinModelPortal	Q9U470
PRIDE	Q9U470
FlyBase	FBgn0026379
Reactome	REACT_180738 REACT_180765 REACT_184384 REACT_235957 REACT_249658
SignaLink	Q9U470
Bgee	Q9U470
ExpressionAtlas	Q9U470
GO	GO:0003779 GO:0051717 GO:0004726 GO:0030165 GO:0016314 GO:0051800 GO:0004438 GO:0004721 GO:0004722 GO:0004725 GO:0008138 GO:0030036 GO:0007015 GO:0006915 GO:0006914 GO:0007155 GO:0008283 GO:0009987 GO:0034613 GO:0007010 GO:0031104 GO:0007425 GO:0046855 GO:0008286 GO:0002164 GO:0035069 GO:0007436 GO:0006629 GO:0019915 GO:0035011 GO:0007552 GO:0048681 GO:0045786 GO:0030308 GO:0030336 GO:0008285 GO:0045792 GO:0051895 GO:0045926 GO:0046627 GO:0040015 GO:0046621 GO:0051898 GO:0016322 GO:0009887 GO:0035335 GO:0046856 GO:0006470 GO:0043491 GO:0010506 GO:1901888 GO:0008360 GO:0008361 GO:0050773 GO:0090175 GO:0035206 GO:0040014 GO:0046620 GO:0031647 GO:0042594 GO:0042052 GO:0007525 GO:0009888
Gene3D	3.90.190.10
InterPro	IPR000008 IPR000340 IPR029021 IPR014020 IPR029023 IPR016130
Pfam	PF00782 PF10409
SUPFAM	SSF49562 SSF52799
PROSITE	PS51182 PS51181 PS00383

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0008283	cell proliferation	PMID:22363644^[1]	ECO:0000314			P	Figure 1 shows cell proliferation in pten mutants to be within a statistically significant time as the positive control. Figure 2 shows the similarity in pten mutants compared to oncogenic cultures known for cell proliferation.	complete CACAO 4457
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P	Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P	Seeded From UniProt	complete
enables	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F	Seeded From UniProt	complete
enables	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F	Seeded From UniProt	complete
involved_in	GO:0046855	inositol phosphate dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P	Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	PMID:10790335^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8INB9	P	Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P	Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P	Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F	Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F	Seeded From UniProt	complete
enables	GO:0004438	phosphatidylinositol-3-phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F	Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PMID:10617573^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:9588	F	Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PMID:10617573^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015279	F	Seeded From UniProt	complete
involved_in	GO:0046856	phosphatidylinositol dephosphorylation	PMID:12559758^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	PMID:12163412^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0040015	negative regulation of multicellular organism growth	PMID:12163412^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007425	epithelial cell fate determination, open tracheal system	PMID:11740943^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:10908588^[7]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
enables	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	PMID:10908587^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:10908587^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046621	negative regulation of organ growth	PMID:10962553^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009888	tissue development	PMID:10790335^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035069	larval midgut histolysis	PMID:22555456^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0260945	P	Seeded From UniProt	complete
involved_in	GO:0035011	melanotic encapsulation of foreign target	PMID:21947570^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035206	regulation of hemocyte proliferation	PMID:20688956^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050773	regulation of dendrite development	PMID:19778508^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:9588	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:9588	C	Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	PMID:15808505^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:15808505^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:17136098^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042052	rhabdomere development	PMID:16431366^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:10790335^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	PMID:10790335^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009987	cellular process	PMID:10790335^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046621	negative regulation of organ growth	PMID:10679387^[17]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	PMID:10617573^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:9588	F	Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	PMID:10617573^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:10617573^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:9588	P	Seeded From UniProt	complete
involved_in	GO:0008361	regulation of cell size	PMID:10617573^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:10617573^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	PMID:16182527^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007552	metamorphosis	PMID:16182527^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002164	larval development	PMID:16182527^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007436	larval salivary gland morphogenesis	PMID:15963974^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:15743877^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:15296715^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:10617573^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035212	cell competition in a multicellular organism	PMID:26287461^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030707	ovarian follicle cell development	PMID:26205122^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071711	basement membrane organization	PMID:24828534^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007525	somatic muscle development	PMID:24191061^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	PMID:23853710^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:23853709^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:23707736^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901888	regulation of cell junction assembly	PMID:23707736^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090175	regulation of establishment of planar polarity	PMID:23707736^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:22952930^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048681	negative regulation of axon regeneration	PMID:22759636^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031104	dendrite regeneration	PMID:22759636^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035069	larval midgut histolysis	PMID:22555456^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0035850	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004725	P	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016130	F	Seeded From UniProt	complete
enables	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000340	F	Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000340 InterPro:IPR016130	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0045926	negative regulation of growth	PMID:12559758^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	PMID:10679387^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Justiniano, SE et al. (2012) Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines. PLoS ONE 7 e31417 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gao, X et al. (2000) Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. Dev. Biol. 221 404-18 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Goberdhan, DC et al. (1999) Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev. 13 3244-58 PubMed GONUTS page
↑ ^4.0 ^4.1 Oldham, S & Hafen, E (2003) Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13 79-85 PubMed GONUTS page
↑ ^5.0 ^5.1 Oldham, S et al. (2002) The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels. Development 129 4103-9 PubMed GONUTS page
↑ Jin, J et al. (2001) Regulation of Drosophila tracheal system development by protein kinase B. Dev. Cell 1 817-27 PubMed GONUTS page
↑ Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
↑ Scanga, SE et al. (2000) The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19 3971-7 PubMed GONUTS page
↑ ^10.0 ^10.1 Denton, D et al. (2012) Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death Differ. 19 1299-307 PubMed GONUTS page
↑ Howell, L et al. (2012) A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. Immunogenetics 64 155-61 PubMed GONUTS page
↑ Sinenko, SA et al. (2010) Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood 116 4612-20 PubMed GONUTS page
↑ Parrish, JZ et al. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63 788-802 PubMed GONUTS page
↑ ^14.0 ^14.1 Gao, T et al. (2005) PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 18 13-24 PubMed GONUTS page
↑ Gutierrez, E et al. (2007) Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature 445 275-80 PubMed GONUTS page
↑ Pinal, N et al. (2006) Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells. Curr. Biol. 16 140-9 PubMed GONUTS page
↑ ^17.0 ^17.1 Weinkove, D & Leevers, SJ (2000) The genetic control of organ growth: insights from Drosophila. Curr. Opin. Genet. Dev. 10 75-80 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Mirth, C et al. (2005) The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. Curr. Biol. 15 1796-807 PubMed GONUTS page
↑ Takeo, S et al. (2005) Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog. Dev. Biol. 284 204-18 PubMed GONUTS page
↑ von Stein, W et al. (2005) Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling. Development 132 1675-86 PubMed GONUTS page
↑ Rusten, TE et al. (2004) Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev. Cell 7 179-92 PubMed GONUTS page
↑ Levayer, R et al. (2015) Cell mixing induced by myc is required for competitive tissue invasion and destruction. Nature 524 476-80 PubMed GONUTS page
↑ Jia, D et al. (2015) A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches. Sci Rep 5 12328 PubMed GONUTS page
↑ Devergne, O et al. (2014) Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U.S.A. 111 7689-94 PubMed GONUTS page
↑ Tixier, V et al. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc. Natl. Acad. Sci. U.S.A. 110 18982-7 PubMed GONUTS page
↑ Rousso, T et al. (2013) Apical targeting of the formin Diaphanous in Drosophila tubular epithelia. Elife 2 e00666 PubMed GONUTS page
↑ Nowak, K et al. (2013) Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues. Elife 2 e00380 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Bardet, PL et al. (2013) PTEN controls junction lengthening and stability during cell rearrangement in epithelial tissue. Dev. Cell 25 534-46 PubMed GONUTS page
↑ Pircs, K et al. (2012) Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila. PLoS ONE 7 e44214 PubMed GONUTS page
↑ ^30.0 ^30.1 Song, Y et al. (2012) Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev. 26 1612-25 PubMed GONUTS page

[PMID:22363644-1] Justiniano, SE et al. (2012) Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines. PLoS ONE 7 e31417 PubMed GONUTS page

[PMID:10790335-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gao, X et al. (2000) Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. Dev. Biol. 221 404-18 PubMed GONUTS page

[PMID:10617573-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Goberdhan, DC et al. (1999) Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev. 13 3244-58 PubMed GONUTS page

[PMID:12559758-4] 4.0 ^4.1 Oldham, S & Hafen, E (2003) Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13 79-85 PubMed GONUTS page

[PMID:12163412-5] 5.0 ^5.1 Oldham, S et al. (2002) The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels. Development 129 4103-9 PubMed GONUTS page

[PMID:11740943-6] Jin, J et al. (2001) Regulation of Drosophila tracheal system development by protein kinase B. Dev. Cell 1 817-27 PubMed GONUTS page

[PMID:10908588-7] Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page

[PMID:10908587-8] 8.0 ^8.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page

[PMID:10962553-9] Scanga, SE et al. (2000) The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19 3971-7 PubMed GONUTS page

[PMID:22555456-10] 10.0 ^10.1 Denton, D et al. (2012) Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death Differ. 19 1299-307 PubMed GONUTS page

[PMID:21947570-11] Howell, L et al. (2012) A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. Immunogenetics 64 155-61 PubMed GONUTS page

[PMID:20688956-12] Sinenko, SA et al. (2010) Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood 116 4612-20 PubMed GONUTS page

[PMID:19778508-13] Parrish, JZ et al. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63 788-802 PubMed GONUTS page

[PMID:15808505-14] 14.0 ^14.1 Gao, T et al. (2005) PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 18 13-24 PubMed GONUTS page

[PMID:17136098-15] Gutierrez, E et al. (2007) Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature 445 275-80 PubMed GONUTS page

[PMID:16431366-16] Pinal, N et al. (2006) Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells. Curr. Biol. 16 140-9 PubMed GONUTS page

[PMID:10679387-17] 17.0 ^17.1 Weinkove, D & Leevers, SJ (2000) The genetic control of organ growth: insights from Drosophila. Curr. Opin. Genet. Dev. 10 75-80 PubMed GONUTS page

[PMID:16182527-18] 18.0 ^18.1 ^18.2 Mirth, C et al. (2005) The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. Curr. Biol. 15 1796-807 PubMed GONUTS page

[PMID:15963974-19] Takeo, S et al. (2005) Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog. Dev. Biol. 284 204-18 PubMed GONUTS page

[PMID:15743877-20] von Stein, W et al. (2005) Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling. Development 132 1675-86 PubMed GONUTS page

[PMID:15296715-21] Rusten, TE et al. (2004) Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev. Cell 7 179-92 PubMed GONUTS page

[PMID:26287461-22] Levayer, R et al. (2015) Cell mixing induced by myc is required for competitive tissue invasion and destruction. Nature 524 476-80 PubMed GONUTS page

[PMID:26205122-23] Jia, D et al. (2015) A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches. Sci Rep 5 12328 PubMed GONUTS page

[PMID:24828534-24] Devergne, O et al. (2014) Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U.S.A. 111 7689-94 PubMed GONUTS page

[PMID:24191061-25] Tixier, V et al. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc. Natl. Acad. Sci. U.S.A. 110 18982-7 PubMed GONUTS page

[PMID:23853710-26] Rousso, T et al. (2013) Apical targeting of the formin Diaphanous in Drosophila tubular epithelia. Elife 2 e00666 PubMed GONUTS page

[PMID:23853709-27] Nowak, K et al. (2013) Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues. Elife 2 e00380 PubMed GONUTS page

[PMID:23707736-28] 28.0 ^28.1 ^28.2 Bardet, PL et al. (2013) PTEN controls junction lengthening and stability during cell rearrangement in epithelial tissue. Dev. Cell 25 534-46 PubMed GONUTS page

[PMID:22952930-29] Pircs, K et al. (2012) Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila. PLoS ONE 7 e44214 PubMed GONUTS page

[PMID:22759636-30] 30.0 ^30.1 Song, Y et al. (2012) Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev. 26 1612-25 PubMed GONUTS page

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DROME:Q9U470

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