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DROME:Q9U470

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Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0008283

cell proliferation

PMID:22363644[1]

IDA: Inferred from Direct Assay

P

Figure 1 shows cell proliferation in pten mutants to be within a statistically significant time as the positive control. Figure 2 shows the similarity in pten mutants compared to oncogenic cultures known for cell proliferation.

complete
CACAO 4457

GO:0002164

larval development

PMID:16182527[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003779

actin binding

PMID:10908588[3]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0004438

phosphatidylinositol-3-phosphatase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

F

Seeded From UniProt

complete

GO:0004721

phosphoprotein phosphatase activity

PMID:10556061[4]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0004721

phosphoprotein phosphatase activity

PMID:10617573[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:9588

F

Seeded From UniProt

complete

GO:0004722

protein serine/threonine phosphatase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

F

Seeded From UniProt

complete

GO:0004722

protein serine/threonine phosphatase activity

PMID:15808505[6]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

F

Seeded From UniProt

complete

GO:0004726

non-membrane spanning protein tyrosine phosphatase activity

PMID:10556061[4]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005634

nucleus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

HGNC:9588

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

HGNC:9588

C

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000340

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:10617573[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:9588

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:10908587[7]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:15808505[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006629

lipid metabolic process

PMID:17136098[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006914

autophagy

PMID:15296715[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10556061[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:11897402[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007010

cytoskeleton organization

PMID:10617573[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007015

actin filament organization

PMID:14527345[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

PMID:14527345[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007425

epithelial cell fate determination, open tracheal system

PMID:11740943[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007436

larval salivary gland morphogenesis

PMID:15963974[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007525

somatic muscle development

PMID:24191061[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007552

metamorphosis

PMID:16182527[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008138

protein tyrosine/serine/threonine phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000340

F

Seeded From UniProt

complete

GO:0008138

protein tyrosine/serine/threonine phosphatase activity

PMID:10556061[4]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0008138

protein tyrosine/serine/threonine phosphatase activity

PMID:10908587[7]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0008283

cell proliferation

PMID:10617573[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008283

cell proliferation

PMID:10790335[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008285

negative regulation of cell proliferation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:10556061[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0015279

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:10556061[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0024248

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:11782950[16]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008360

regulation of cell shape

PMID:10617573[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008360

regulation of cell shape

PMID:14527345[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008360

regulation of cell shape

PMID:23707736[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008361

regulation of cell size

PMID:10556061[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008361

regulation of cell size

PMID:10617573[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008361

regulation of cell size

PMID:11897402[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0009887

organ morphogenesis

PMID:10790335[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009888

tissue development

PMID:10790335[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009987

cellular process

PMID:10790335[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010506

regulation of autophagy

PMID:22952930[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016311

dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016130

P

Seeded From UniProt

complete

GO:0016314

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

PMID:10617573[5]

IGI: Inferred from Genetic Interaction

FB:FBgn0015279

F

Seeded From UniProt

complete

GO:0016314

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

PMID:10617573[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:9588

F

Seeded From UniProt

complete

GO:0016322

neuron remodeling

PMID:24068890[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016791

phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0019915

lipid storage

PMID:17079271[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030036

actin cytoskeleton organization

PMID:15743877[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030165

PDZ domain binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

F

Seeded From UniProt

complete

GO:0030308

negative regulation of cell growth

PMID:11782950[16]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0030336

negative regulation of cell migration

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

P

Seeded From UniProt

complete

GO:0031104

dendrite regeneration

PMID:22759636[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031647

regulation of protein stability

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

P

Seeded From UniProt

complete

GO:0034613

cellular protein localization

PMID:23853710[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035011

melanotic encapsulation of foreign target

PMID:21947570[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035069

larval midgut histolysis

PMID:22555456[25]

IGI: Inferred from Genetic Interaction

FB:FBgn0035850

P

Seeded From UniProt

complete

GO:0035069

larval midgut histolysis

PMID:22555456[25]

IGI: Inferred from Genetic Interaction

FB:FBgn0260945

P

Seeded From UniProt

complete

GO:0035206

regulation of hemocyte proliferation

PMID:20688956[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016130

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:10556061[4]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0040014

regulation of multicellular organism growth

PMID:11897402[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0040014

regulation of multicellular organism growth

PMID:16182527[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040015

negative regulation of multicellular organism growth

PMID:12163412[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042052

rhabdomere development

PMID:16431366[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042594

response to starvation

PMID:12163412[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043491

protein kinase B signaling

PMID:10790335[15]

IGI: Inferred from Genetic Interaction

UniProtKB:Q8INB9

P

Seeded From UniProt

complete

GO:0045786

negative regulation of cell cycle

PMID:11897402[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045792

negative regulation of cell size

PMID:10679387[29]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045792

negative regulation of cell size

PMID:11377964[30]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045926

negative regulation of growth

PMID:12559758[31]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046620

regulation of organ growth

PMID:11897402[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046621

negative regulation of organ growth

PMID:10679387[29]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046621

negative regulation of organ growth

PMID:10962553[32]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046621

negative regulation of organ growth

PMID:11128988[33]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046621

negative regulation of organ growth

PMID:11377964[30]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:11128988[33]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:11377964[30]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:11897402[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046855

inositol phosphate dephosphorylation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

P

Seeded From UniProt

complete

GO:0046856

phosphatidylinositol dephosphorylation

PMID:11128988[33]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046856

phosphatidylinositol dephosphorylation

PMID:12559758[31]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0048681

negative regulation of axon regeneration

PMID:22759636[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050773

regulation of dendrite development

PMID:19778508[34]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051717

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

F

Seeded From UniProt

complete

GO:0051726

regulation of cell cycle

PMID:23853709[35]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051800

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

F

Seeded From UniProt

complete

GO:0051895

negative regulation of focal adhesion assembly

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

P

Seeded From UniProt

complete

GO:0051898

negative regulation of protein kinase B signaling

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P60484

P

Seeded From UniProt

complete

GO:0071711

basement membrane organization

PMID:24828534[36]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0090175

regulation of establishment of planar polarity

PMID:23707736[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1901888

regulation of cell junction assembly

PMID:23707736[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Justiniano, SE et al. (2012) Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines. PLoS ONE 7 e31417 PubMed GONUTS page
  2. 2.0 2.1 2.2 Mirth, C et al. (2005) The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. Curr. Biol. 15 1796-807 PubMed GONUTS page
  3. Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Huang, H et al. (1999) PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development 126 5365-72 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Goberdhan, DC et al. (1999) Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev. 13 3244-58 PubMed GONUTS page
  6. 6.0 6.1 Gao, T et al. (2005) PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 18 13-24 PubMed GONUTS page
  7. 7.0 7.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  8. Gutierrez, E et al. (2007) Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature 445 275-80 PubMed GONUTS page
  9. Rusten, TE et al. (2004) Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev. Cell 7 179-92 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 10.5 Claeys, I et al. (2002) Insulin-related peptides and their conserved signal transduction pathway. Peptides 23 807-16 PubMed GONUTS page
  11. 11.0 11.1 11.2 Kiger, AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J. Biol. 2 27 PubMed GONUTS page
  12. Jin, J et al. (2001) Regulation of Drosophila tracheal system development by protein kinase B. Dev. Cell 1 817-27 PubMed GONUTS page
  13. Takeo, S et al. (2005) Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog. Dev. Biol. 284 204-18 PubMed GONUTS page
  14. Tixier, V et al. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc. Natl. Acad. Sci. U.S.A. 110 18982-7 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 15.4 Gao, X et al. (2000) Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. Dev. Biol. 221 404-18 PubMed GONUTS page
  16. 16.0 16.1 Johnston, LA & Gallant, P (2002) Control of growth and organ size in Drosophila. Bioessays 24 54-64 PubMed GONUTS page
  17. 17.0 17.1 17.2 Bardet, PL et al. (2013) PTEN controls junction lengthening and stability during cell rearrangement in epithelial tissue. Dev. Cell 25 534-46 PubMed GONUTS page
  18. Pircs, K et al. (2012) Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila. PLoS ONE 7 e44214 PubMed GONUTS page
  19. Wong, JJ et al. (2013) A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. PLoS Biol. 11 e1001657 PubMed GONUTS page
  20. Vereshchagina, N & Wilson, C (2006) Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells. Development 133 4731-5 PubMed GONUTS page
  21. von Stein, W et al. (2005) Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling. Development 132 1675-86 PubMed GONUTS page
  22. 22.0 22.1 Song, Y et al. (2012) Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev. 26 1612-25 PubMed GONUTS page
  23. Rousso, T et al. (2013) Apical targeting of the formin Diaphanous in Drosophila tubular epithelia. Elife 2 e00666 PubMed GONUTS page
  24. Howell, L et al. (2012) A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. Immunogenetics 64 155-61 PubMed GONUTS page
  25. 25.0 25.1 Denton, D et al. (2012) Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death Differ. 19 1299-307 PubMed GONUTS page
  26. Sinenko, SA et al. (2010) Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood 116 4612-20 PubMed GONUTS page
  27. 27.0 27.1 Oldham, S et al. (2002) The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels. Development 129 4103-9 PubMed GONUTS page
  28. Pinal, N et al. (2006) Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells. Curr. Biol. 16 140-9 PubMed GONUTS page
  29. 29.0 29.1 Weinkove, D & Leevers, SJ (2000) The genetic control of organ growth: insights from Drosophila. Curr. Opin. Genet. Dev. 10 75-80 PubMed GONUTS page
  30. 30.0 30.1 30.2 Potter, CJ & Xu, T (2001) Mechanisms of size control. Curr. Opin. Genet. Dev. 11 279-86 PubMed GONUTS page
  31. 31.0 31.1 Oldham, S & Hafen, E (2003) Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13 79-85 PubMed GONUTS page
  32. Scanga, SE et al. (2000) The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19 3971-7 PubMed GONUTS page
  33. 33.0 33.1 33.2 Oldham, S et al. (2000) Genetic control of size in Drosophila. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 945-52 PubMed GONUTS page
  34. Parrish, JZ et al. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63 788-802 PubMed GONUTS page
  35. Nowak, K et al. (2013) Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues. Elife 2 e00380 PubMed GONUTS page
  36. Devergne, O et al. (2014) Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U.S.A. 111 7689-94 PubMed GONUTS page