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DROME:Q9NFX0

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Acon (ECO:0000313 with FlyBase:FBgn0010100) (synonyms: mAc (ECO:0000313 with EMBL:CAB93522.1))
Protein Name(s) Mitochondrial aconitase (ECO:0000313 with EMBL:CAB93522.1)
External Links
UniProt Q9NFX0
EMBL AJ252019
FlyBase FBgn0010100
ChiTaRS Acon
GO GO:0005811
GO:0005739
GO:0003994
GO:0006099

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0051539

4 iron, 4 sulfur cluster binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
PANTHER:PTN000186533
RGD:621360
UniProtKB:P20004

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010100
PANTHER:PTN000186533
RGD:621360
SGD:S000004295
UniProtKB:Q8ZRS8
UniProtKB:Q99798

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
PANTHER:PTN001705783
SGD:S000004295

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010100
MGI:MGI:87880
PANTHER:PTN000186534
PomBase:SPAC24C9.06c
PomBase:SPBP4H10.15
RGD:621360
UniProtKB:P20004

C

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
MGI:MGI:87880
PANTHER:PTN000186533
RGD:621360
SGD:S000004295
UniProtKB:C8VG90
UniProtKB:P20004
UniProtKB:Q4WLN1
UniProtKB:Q8ZRS8
UniProtKB:Q99798

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:19317464[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:23637640[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000110

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99798

C

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

GO_REF:0000110

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99798

F

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

PMID:11095759[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

PMID:23438437[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:16212416[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
  3. Esposito, G et al. (2013) Aconitase causes iron toxicity in Drosophila pink1 mutants. PLoS Genet. 9 e1003478 PubMed GONUTS page
  4. Zou, S et al. (2000) Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 97 13726-31 PubMed GONUTS page
  5. Cheng, Z et al. (2013) Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency. Biochem. Biophys. Res. Commun. 433 145-50 PubMed GONUTS page
  6. Alonso, J et al. () Characterization of the Drosophila melanogaster mitochondrial proteome. J. Proteome Res. 4 1636-45 PubMed GONUTS page