DROME:PTP69

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Ptp69D (synonyms: DPTP)
Protein Name(s)	Tyrosine-protein phosphatase 69D Protein-tyrosine-phosphate phosphohydrolase DPTP
External Links
UniProt	P16620
EMBL	M27699 AE014296 AE014296 BT001531
PIR	B36182
RefSeq	NP_524048.2 NP_788502.1
UniGene	Dm.945
ProteinModelPortal	P16620
SMR	P16620
BioGrid	64791
IntAct	P16620
MINT	MINT-5227360
PaxDb	P16620
PRIDE	P16620
EnsemblMetazoa	FBtr0075913
GeneID	39443
KEGG	dme:Dmel_CG10975
CTD	39443
FlyBase	FBgn0014007
eggNOG	COG5599
GeneTree	ENSGT00760000118900
InParanoid	P16620
KO	K01104
OMA	YNGWPTV
OrthoDB	EOG7034G2
PhylomeDB	P16620
Reactome	REACT_214284 REACT_242620
GenomeRNAi	39443
NextBio	813657
Proteomes	UP000000803
Bgee	P16620
ExpressionAtlas	P16620
GO	GO:0030424 GO:0016021 GO:0005886 GO:0004725 GO:0005001 GO:0007411 GO:0007414 GO:0007409 GO:0007155 GO:0007415 GO:0048813 GO:0046331 GO:0008045 GO:0035335 GO:0006470
Gene3D	2.60.40.10 3.90.190.10
InterPro	IPR003961 IPR007110 IPR013783 IPR003599 IPR003598 IPR029021 IPR000387 IPR016130 IPR000242
Pfam	PF00041 PF00102
PRINTS	PR00700
SMART	SM00060 SM00409 SM00408 SM00194
SUPFAM	SSF49265 SSF52799
PROSITE	PS50853 PS50835 PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0008045	motor neuron axon guidance	PMID:8598046^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:8598046^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004369	P	Seeded From UniProt	complete
involved_in	GO:0007415	defasciculation of motor neuron axon	PMID:8598046^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007415	defasciculation of motor neuron axon	PMID:8598046^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004369	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:2554325^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	PMID:2554325^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:25294944^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19317464^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:23764287^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0002306	P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:23764287^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004370	P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:18516287^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:18237413^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:18237413^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004368,FB:FBgn0004370	P	Seeded From UniProt	complete
involved_in	GO:0097155	fasciculation of sensory neuron axon	PMID:17164414^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	PMID:17164414^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:11178866^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004370	P	Seeded From UniProt	complete
involved_in	GO:0016201	synaptic target inhibition	PMID:27780041^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR016130	F	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242	P	Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P	Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P	Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Desai, CJ et al. (1996) Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell 84 599-609 PubMed GONUTS page
↑ ^2.0 ^2.1 Streuli, M et al. (1989) A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila. Proc. Natl. Acad. Sci. U.S.A. 86 8698-702 PubMed GONUTS page
↑ Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page
↑ Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
↑ ^5.0 ^5.1 Lee, HK et al. (2013) Interactions between a receptor tyrosine phosphatase and a cell surface ligand regulate axon guidance and glial-neuronal communication. Neuron 78 813-26 PubMed GONUTS page
↑ Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page
↑ ^7.0 ^7.1 Jeon, M et al. (2008) Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev 3 3 PubMed GONUTS page
↑ ^8.0 ^8.1 Grueber, WB et al. (2007) Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. Development 134 55-64 PubMed GONUTS page
↑ Sun, Q et al. (2001) Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Mol. Cell. Neurosci. 17 274-91 PubMed GONUTS page
↑ Oliva, C et al. (2016) Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex. Dev. Cell 39 267-278 PubMed GONUTS page

[PMID:8598046-1] 1.0 ^1.1 ^1.2 ^1.3 Desai, CJ et al. (1996) Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell 84 599-609 PubMed GONUTS page

[PMID:2554325-2] 2.0 ^2.1 Streuli, M et al. (1989) A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila. Proc. Natl. Acad. Sci. U.S.A. 86 8698-702 PubMed GONUTS page

[PMID:25294944-3] Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page

[PMID:19317464-4] Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page

[PMID:23764287-5] 5.0 ^5.1 Lee, HK et al. (2013) Interactions between a receptor tyrosine phosphatase and a cell surface ligand regulate axon guidance and glial-neuronal communication. Neuron 78 813-26 PubMed GONUTS page

[PMID:18516287-6] Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page

[PMID:18237413-7] 7.0 ^7.1 Jeon, M et al. (2008) Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev 3 3 PubMed GONUTS page

[PMID:17164414-8] 8.0 ^8.1 Grueber, WB et al. (2007) Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. Development 134 55-64 PubMed GONUTS page

[PMID:11178866-9] Sun, Q et al. (2001) Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Mol. Cell. Neurosci. 17 274-91 PubMed GONUTS page

[PMID:27780041-10] Oliva, C et al. (2016) Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex. Dev. Cell 39 267-278 PubMed GONUTS page

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DROME:PTP69

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