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DROME:PTP69

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Ptp69D (synonyms: DPTP)
Protein Name(s) Tyrosine-protein phosphatase 69D

Protein-tyrosine-phosphate phosphohydrolase DPTP

External Links
UniProt P16620
EMBL M27699
AE014296
AE014296
BT001531
PIR B36182
RefSeq NP_524048.2
NP_788502.1
UniGene Dm.945
ProteinModelPortal P16620
SMR P16620
BioGrid 64791
IntAct P16620
MINT MINT-5227360
PaxDb P16620
PRIDE P16620
EnsemblMetazoa FBtr0075913
GeneID 39443
KEGG dme:Dmel_CG10975
CTD 39443
FlyBase FBgn0014007
eggNOG COG5599
GeneTree ENSGT00760000118900
InParanoid P16620
KO K01104
OMA YNGWPTV
OrthoDB EOG7034G2
PhylomeDB P16620
Reactome REACT_214284
REACT_242620
GenomeRNAi 39443
NextBio 813657
Proteomes UP000000803
Bgee P16620
ExpressionAtlas P16620
GO GO:0030424
GO:0016021
GO:0005886
GO:0004725
GO:0005001
GO:0007411
GO:0007414
GO:0007409
GO:0007155
GO:0007415
GO:0048813
GO:0046331
GO:0008045
GO:0035335
GO:0006470
Gene3D 2.60.40.10
3.90.190.10
InterPro IPR003961
IPR007110
IPR013783
IPR003599
IPR003598
IPR029021
IPR000387
IPR016130
IPR000242
Pfam PF00041
PF00102
PRINTS PR00700
SMART SM00060
SM00409
SM00408
SM00194
SUPFAM SSF49265
SSF52799
PROSITE PS50853
PS50835
PS00383
PS50056
PS50055

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242
InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.48

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:10908587[1]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:2554325[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005001

transmembrane receptor protein tyrosine phosphatase activity

PMID:2554325[2]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005886

plasma membrane

PMID:19317464[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:20462449[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:25294944[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:2554325[2]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0006470

protein dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:10908587[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:2554325[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:11891122[6]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:18516287[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:23764287[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0002306

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:23764287[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0004370

P

Seeded From UniProt

complete

GO:0007414

axonal defasciculation

PMID:9529614[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007415

defasciculation of motor neuron axon

PMID:8598046[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0004369

P

Seeded From UniProt

complete

GO:0007415

defasciculation of motor neuron axon

PMID:8598046[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:11178866[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0004370

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:18237413[12]

IGI: Inferred from Genetic Interaction

FB:FBgn0004368
FB:FBgn0004370

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:8598046[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0004369

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:8598046[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016311

dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000387
InterPro:IPR016130

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0016791

phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000387
InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0030424

axon

PMID:18237413[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242
InterPro:IPR016130

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.48

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:10908587[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:2554325[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:2554325[2]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0046331

lateral inhibition

PMID:19363474[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048813

dendrite morphogenesis

PMID:17164414[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0097155

fasciculation of sensory neuron axon

PMID:17164414[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Streuli, M et al. (1989) A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila. Proc. Natl. Acad. Sci. U.S.A. 86 8698-702 PubMed GONUTS page
  3. Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
  4. Khanna, MR et al. (2010) Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. BMC Genomics 11 302 PubMed GONUTS page
  5. Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page
  6. Patel, BN & Van Vactor, DL (2002) Axon guidance: the cytoplasmic tail. Curr. Opin. Cell Biol. 14 221-9 PubMed GONUTS page
  7. Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page
  8. 8.0 8.1 Lee, HK et al. (2013) Interactions between a receptor tyrosine phosphatase and a cell surface ligand regulate axon guidance and glial-neuronal communication. Neuron 78 813-26 PubMed GONUTS page
  9. Van Vactor, D et al. (1998) Genetic analysis of protein tyrosine phosphatases. Curr. Opin. Genet. Dev. 8 112-26 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Desai, CJ et al. (1996) Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell 84 599-609 PubMed GONUTS page
  11. Sun, Q et al. (2001) Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Mol. Cell. Neurosci. 17 274-91 PubMed GONUTS page
  12. 12.0 12.1 Jeon, M et al. (2008) Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev 3 3 PubMed GONUTS page
  13. Mummery-Widmer, JL et al. (2009) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature 458 987-92 PubMed GONUTS page
  14. 14.0 14.1 Grueber, WB et al. (2007) Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. Development 134 55-64 PubMed GONUTS page