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DROME:PTP61

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Ptp61F
Protein Name(s) Tyrosine-protein phosphatase non-receptor type 61F

dPTP61F

External Links
UniProt Q9W0G1
EMBL L11250
L11249
L11251
L11249
L11250
L11252
L11253
L14849
AE014296
AE014296
AE014296
AY069713
PIR A46101
B46101
RefSeq NP_476687.1
NP_476688.1
NP_728600.1
UniGene Dm.1991
ProteinModelPortal Q9W0G1
SMR Q9W0G1
BioGrid 63702
IntAct Q9W0G1
MINT MINT-823894
PaxDb Q9W0G1
PRIDE Q9W0G1
EnsemblMetazoa FBtr0072718
GeneID 38160
KEGG dme:Dmel_CG9181
CTD 38160
FlyBase FBgn0003138
eggNOG COG5599
GeneTree ENSGT00770000120472
InParanoid Q9W0G1
KO K05696
OMA FCLVDCC
OrthoDB EOG7RV9G4
PhylomeDB Q9W0G1
Reactome REACT_229887
GenomeRNAi 38160
NextBio 807270
PRO PR:Q9W0G1
Proteomes UP000000803
Bgee Q9W0G1
ExpressionAtlas Q9W0G1
GO GO:0012505
GO:0016020
GO:0005740
GO:0005634
GO:0004725
GO:0007377
Gene3D 3.90.190.10
InterPro IPR029021
IPR000387
IPR016130
IPR000242
Pfam PF00102
PRINTS PR00700
SMART SM00194
SUPFAM SSF52799
PROSITE PS00383
PS50056
PS50055

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0048570

notochord morphogenesis

PMID:8663600[1]

IDA: Inferred from Direct Assay

P

Figure 3-Both messages have overlapping expression patterns in the brain (b) and ventral nerve cord (vnc)

complete
CACAO 6075

GO:0043631

RNA polyadenylation

PMID:8663600[1]

IDA: Inferred from Direct Assay

P

Figure 3

complete
CACAO 6077

GO:0003735

structural constituent of ribosome

PMID:8663600[1]

IDA: Inferred from Direct Assay

F

Figure 3

complete
CACAO 6078

GO:0016020

membrane

PMID:8663600[1]

IDA: Inferred from Direct Assay

C

Figure 3

complete
CACAO 6079

GO:0043631

granulocyte colony-stimulating factor receptor activity

PMID:8663600[1]

IDA: Inferred from Direct Assay

F

Figure 3

complete
CACAO 6125

GO:0000278

mitotic cell cycle

PMID:17306545[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242
InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.48

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:10908587[3]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:11095759[4]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:17804420[5]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:21707536[6]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:8463208[7]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17804420[5]

IPI: Inferred from Physical Interaction

FB:FBgn0020510

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:8663600[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q24218

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:8463208[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:8463208[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005740

mitochondrial envelope

PMID:8463208[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:10908587[3]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:8463208[7]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007176

regulation of epidermal growth factor-activated receptor activity

PMID:24752400[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0003731

P

Seeded From UniProt

complete

GO:0007377

germ-band extension

PMID:9256342[9]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:8663600[1]

IPI: Inferred from Physical Interaction

FB:FBgn0010583

P

Seeded From UniProt

complete

GO:0008285

negative regulation of cell proliferation

PMID:23339871[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0012505

endomembrane system

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0147

C

Seeded From UniProt

complete

GO:0014067

negative regulation of phosphatidylinositol 3-kinase signaling

PMID:24752400[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0010379

P

Seeded From UniProt

complete

GO:0014067

negative regulation of phosphatidylinositol 3-kinase signaling

PMID:24752400[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0015279

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016311

dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000387
InterPro:IPR016130

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0016791

phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000387
InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0031647

regulation of protein stability

PMID:17804420[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0032880

regulation of protein localization

PMID:17804420[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:21707536[6]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0043407

negative regulation of MAP kinase activity

PMID:24752400[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0003256

P

Seeded From UniProt

complete

GO:0046426

negative regulation of JAK-STAT cascade

PMID:16094372[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046580

negative regulation of Ras protein signal transduction

PMID:24752400[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0003205

P

Seeded From UniProt

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:21707536[6]

IGI: Inferred from Genetic Interaction

FB:FBgn0013984

P

Seeded From UniProt

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:24752400[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0013984

P

Seeded From UniProt

complete

GO:0048471

perinuclear region of cytoplasm

PMID:17804420[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0050732

negative regulation of peptidyl-tyrosine phosphorylation

PMID:17804420[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071456

cellular response to hypoxia

PMID:18653470[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Clemens, JC et al. (1996) A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance. J. Biol. Chem. 271 17002-5 PubMed GONUTS page
  2. Chen, F et al. (2007) Multiple protein phosphatases are required for mitosis in Drosophila. Curr. Biol. 17 293-303 PubMed GONUTS page
  3. 3.0 3.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  4. Zou, S et al. (2000) Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 97 13726-31 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Huang, CH et al. (2007) The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J. Biol. Chem. 282 32442-52 PubMed GONUTS page
  6. 6.0 6.1 6.2 Wu, CL et al. (2011) Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling. Biochem. J. 439 151-9 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 McLaughlin, S & Dixon, JE (1993) Alternative splicing gives rise to a nuclear protein tyrosine phosphatase in Drosophila. J. Biol. Chem. 268 6839-42 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 Tchankouo-Nguetcheu, S et al. (2014) Negative regulation of MAP kinase signaling in Drosophila by Ptp61F/PTP1B. Mol. Genet. Genomics 289 795-806 PubMed GONUTS page
  9. Ursuliak, Z et al. (1997) Differential accumulation of DPTP61F alternative transcripts: regulation of a protein tyrosine phosphatase by segmentation genes. Mech. Dev. 65 19-30 PubMed GONUTS page
  10. Buszard, BJ et al. (2013) The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity. Mol. Cell. Biol. 33 1345-56 PubMed GONUTS page
  11. Müller, P et al. (2005) Identification of JAK/STAT signalling components by genome-wide RNA interference. Nature 436 871-5 PubMed GONUTS page
  12. Lee, SJ et al. (2008) An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol. Biol. Cell 19 4051-61 PubMed GONUTS page