DROME:PTP61

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Ptp61F
Protein Name(s)	Tyrosine-protein phosphatase non-receptor type 61F dPTP61F
External Links
UniProt	Q9W0G1
EMBL	L11250 L11249 L11251 L11249 L11250 L11252 L11253 L14849 AE014296 AE014296 AE014296 AY069713
PIR	A46101 B46101
RefSeq	NP_476687.1 NP_476688.1 NP_728600.1
UniGene	Dm.1991
ProteinModelPortal	Q9W0G1
SMR	Q9W0G1
BioGrid	63702
IntAct	Q9W0G1
MINT	MINT-823894
PaxDb	Q9W0G1
PRIDE	Q9W0G1
EnsemblMetazoa	FBtr0072718
GeneID	38160
KEGG	dme:Dmel_CG9181
CTD	38160
FlyBase	FBgn0003138
eggNOG	COG5599
GeneTree	ENSGT00770000120472
InParanoid	Q9W0G1
KO	K05696
OMA	FCLVDCC
OrthoDB	EOG7RV9G4
PhylomeDB	Q9W0G1
Reactome	REACT_229887
GenomeRNAi	38160
NextBio	807270
PRO	PR:Q9W0G1
Proteomes	UP000000803
Bgee	Q9W0G1
ExpressionAtlas	Q9W0G1
GO	GO:0012505 GO:0016020 GO:0005740 GO:0005634 GO:0004725 GO:0007377
Gene3D	3.90.190.10
InterPro	IPR029021 IPR000387 IPR016130 IPR000242
Pfam	PF00102
PRINTS	PR00700
SMART	SM00194
SUPFAM	SSF52799
PROSITE	PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048570	notochord morphogenesis	PMID:8663600^[1]	ECO:0000314			P		Figure 3-Both messages have overlapping expression patterns in the brain (b) and ventral nerve cord (vnc)	complete CACAO 6075
	GO:0043631	RNA polyadenylation	PMID:8663600^[1]	ECO:0000314			P		Figure 3	complete CACAO 6077
	GO:0003735	structural constituent of ribosome	PMID:8663600^[1]	ECO:0000314			F		Figure 3	complete CACAO 6078
	GO:0016020	membrane	PMID:8663600^[1]	ECO:0000314			C		Figure 3	complete CACAO 6079
	GO:0043631	granulocyte colony-stimulating factor receptor activity	PMID:8663600^[1]	ECO:0000314			F		Figure 3	complete CACAO 6125
involved_in	GO:0007377	germ-band extension	PMID:9256342^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005740	mitochondrial envelope	PMID:8463208^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	PMID:28544778^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0031888	P		Seeded From UniProt	complete
involved_in	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	PMID:28544778^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003731	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	PMID:24752400^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003205	P		Seeded From UniProt	complete
involved_in	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	PMID:24752400^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015279	P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:24752400^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0283499	P		Seeded From UniProt	complete
involved_in	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	PMID:24752400^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0010379	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	PMID:24752400^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003256	P		Seeded From UniProt	complete
involved_in	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	PMID:24752400^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003731	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:23339871^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:22825871^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:22825871^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:21707536^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0283499	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:21707536^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(FB:FBgn0283499) part_of:(GO:0046627)	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:21707536^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:18653470^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:17804420^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:17804420^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:17804420^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:17804420^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:17804420^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:17306545^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	PMID:16094372^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:8663600^[1]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0010583	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:8463208^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8463208^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:8463208^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:8463208^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:28544778^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0016917	F	has_direct_input:(FB:FBgn0016917) part_of:(GO:0046426)\|has_direct_input(FB:FBgn0004864) part_of:(GO:0046426)	Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:28544778^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0010583	P		Seeded From UniProt	complete
involved_in	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	PMID:28544778^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046329	negative regulation of JNK cascade	PMID:28544778^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0031888	P	part_of:(GO:0030948)	Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	PMID:28544778^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003731	P	part_of:(GO:0042059)	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR016130	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
involved_in	GO:0007259	receptor signaling pathway via JAK-STAT	Reactome:R-DME-209405	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-DME-210662	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	Reactome:R-DME-210662	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Clemens, JC et al. (1996) A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance. J. Biol. Chem. 271 17002-5 PubMed GONUTS page
↑ Ursuliak, Z et al. (1997) Differential accumulation of DPTP61F alternative transcripts: regulation of a protein tyrosine phosphatase by segmentation genes. Mech. Dev. 65 19-30 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 McLaughlin, S & Dixon, JE (1993) Alternative splicing gives rise to a nuclear protein tyrosine phosphatase in Drosophila. J. Biol. Chem. 268 6839-42 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Willoughby, LF et al. (2017) Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants. FEBS J. 284 2231-2250 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Tchankouo-Nguetcheu, S et al. (2014) Negative regulation of MAP kinase signaling in Drosophila by Ptp61F/PTP1B. Mol. Genet. Genomics 289 795-806 PubMed GONUTS page
↑ Buszard, BJ et al. (2013) The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity. Mol. Cell. Biol. 33 1345-56 PubMed GONUTS page
↑ ^7.0 ^7.1 Chen, DY et al. (2012) The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration. J. Cell. Sci. 125 4841-52 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Wu, CL et al. (2011) Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling. Biochem. J. 439 151-9 PubMed GONUTS page
↑ Lee, SJ et al. (2008) An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol. Biol. Cell 19 4051-61 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Huang, CH et al. (2007) The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J. Biol. Chem. 282 32442-52 PubMed GONUTS page
↑ Chen, F et al. (2007) Multiple protein phosphatases are required for mitosis in Drosophila. Curr. Biol. 17 293-303 PubMed GONUTS page
↑ Müller, P et al. (2005) Identification of JAK/STAT signalling components by genome-wide RNA interference. Nature 436 871-5 PubMed GONUTS page

[PMID:8663600-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Clemens, JC et al. (1996) A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance. J. Biol. Chem. 271 17002-5 PubMed GONUTS page

[PMID:9256342-2] Ursuliak, Z et al. (1997) Differential accumulation of DPTP61F alternative transcripts: regulation of a protein tyrosine phosphatase by segmentation genes. Mech. Dev. 65 19-30 PubMed GONUTS page

[PMID:8463208-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 McLaughlin, S & Dixon, JE (1993) Alternative splicing gives rise to a nuclear protein tyrosine phosphatase in Drosophila. J. Biol. Chem. 268 6839-42 PubMed GONUTS page

[PMID:28544778-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Willoughby, LF et al. (2017) Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants. FEBS J. 284 2231-2250 PubMed GONUTS page

[PMID:24752400-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Tchankouo-Nguetcheu, S et al. (2014) Negative regulation of MAP kinase signaling in Drosophila by Ptp61F/PTP1B. Mol. Genet. Genomics 289 795-806 PubMed GONUTS page

[PMID:23339871-6] Buszard, BJ et al. (2013) The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity. Mol. Cell. Biol. 33 1345-56 PubMed GONUTS page

[PMID:22825871-7] 7.0 ^7.1 Chen, DY et al. (2012) The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration. J. Cell. Sci. 125 4841-52 PubMed GONUTS page

[PMID:21707536-8] 8.0 ^8.1 ^8.2 Wu, CL et al. (2011) Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling. Biochem. J. 439 151-9 PubMed GONUTS page

[PMID:18653470-9] Lee, SJ et al. (2008) An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol. Biol. Cell 19 4051-61 PubMed GONUTS page

[PMID:17804420-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Huang, CH et al. (2007) The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J. Biol. Chem. 282 32442-52 PubMed GONUTS page

[PMID:17306545-11] Chen, F et al. (2007) Multiple protein phosphatases are required for mitosis in Drosophila. Curr. Biol. 17 293-303 PubMed GONUTS page

[PMID:16094372-12] Müller, P et al. (2005) Identification of JAK/STAT signalling components by genome-wide RNA interference. Nature 436 871-5 PubMed GONUTS page

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DROME:PTP61

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Annotations

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References

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