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PMID:8463208
| Citation |
McLaughlin, S and Dixon, JE (1993) Alternative splicing gives rise to a nuclear protein tyrosine phosphatase in Drosophila. J. Biol. Chem. 268:6839-42 |
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| Abstract |
A novel Drosophila protein tyrosine phosphatase gene (dPTP61F) undergoes alternative splicing to encode two non-receptor-like proteins of 61,000 daltons. This splice selection occurs at the 3' end of the message, altering the carboxyl termini of the encoded proteins. These carboxyl-terminal sequences govern the targeting of each protein tyrosine phosphatase either to a cytoplasmic membrane or to the nucleus. The catalytic activity of the two protein products is indistinguishable, suggesting that substrate specificity is modulated by the protein's subcellular location. |
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| Keywords |
Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Nucleus/enzymology; DNA; Drosophila; Fluorescent Antibody Technique; Humans; Molecular Sequence Data; Phosphorylation; Protein Tyrosine Phosphatases/genetics; Protein Tyrosine Phosphatases/metabolism; Sequence Homology, Amino Acid |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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