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DROME:PARP

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Parp
Protein Name(s) Poly [ADP-ribose] polymerase

PARP NAD(+) ADP-ribosyltransferase ADPRT Poly[ADP-ribose] synthase

External Links
UniProt P35875
EMBL D13806
AF051548
AF051544
AF051545
AF051546
AF051547
AF533701
CM000459
BT015238
AY118947
PIR A47474
RefSeq NP_001104452.1
UniGene Dm.7847
ProteinModelPortal P35875
SMR P35875
BioGrid 78234
DIP DIP-23413N
IntAct P35875
MINT MINT-836001
PaxDb P35875
PRIDE P35875
EnsemblMetazoa FBtr0113885
GeneID 3355109
KEGG dme:Dmel_CG40411
CTD 3355109
FlyBase FBgn0010247
eggNOG NOG243963
GeneTree ENSGT00390000017341
InParanoid P35875
KO K10798
OMA DAKVPNW
OrthoDB EOG7KM5S0
PhylomeDB P35875
Reactome REACT_181669
GenomeRNAi 3355109
NextBio 850624
PRO PR:P35875
Proteomes UP000000803
Bgee P35875
GO GO:0015030
GO:0005694
GO:0035363
GO:0005719
GO:0005730
GO:0005700
GO:0005703
GO:0003677
GO:0042393
GO:0051287
GO:0003950
GO:0008270
GO:0030576
GO:0016568
GO:0051276
GO:0035080
GO:0045087
GO:0051457
GO:0007552
GO:0048812
GO:0007000
GO:0035079
GO:0006963
GO:0006471
GO:0043484
GO:0006355
GO:0009303
Gene3D 1.20.142.10
2.20.140.10
3.30.1740.10
3.40.50.10190
3.90.228.10
InterPro IPR001357
IPR008288
IPR012982
IPR012317
IPR004102
IPR008893
IPR001510
Pfam PF00533
PF08063
PF00644
PF02877
PF05406
PF00645
PIRSF PIRSF000489
SMART SM00292
SM00773
SUPFAM SSF142921
SSF47587
SSF52113
PROSITE PS50172
PS51060
PS51059
PS00347
PS50064

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001510
InterPro:IPR008288

F

Seeded From UniProt

complete

GO:1900182

positive regulation of protein localization to nucleus

PMID:24055367[1]

IMP: Inferred from Mutant Phenotype

P

Fig 3C

complete
CACAO 8989

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003950

NAD+ ADP-ribosyltransferase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004102
InterPro:IPR008288
InterPro:IPR012317
InterPro:IPR012982

F

Seeded From UniProt

complete

GO:0003950

NAD+ ADP-ribosyltransferase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.4.2.30

F

Seeded From UniProt

complete

GO:0003950

NAD+ ADP-ribosyltransferase activity

PMID:17827147[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008288
InterPro:IPR012982

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005694

chromosome

PMID:16219773[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005700

polytene chromosome

PMID:12543962[4]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005700

polytene chromosome

PMID:12543974[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005700

polytene chromosome

PMID:15273990[6]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005703

polytene chromosome puff

PMID:12543962[4]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005703

polytene chromosome puff

PMID:12543974[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005719

nuclear euchromatin

PMID:12543974[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005730

nucleolus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

GO:0005730

nucleolus

PMID:12543962[4]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005730

nucleolus

PMID:15273990[6]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005730

nucleolus

PMID:16219773[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006302

double-strand break repair

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000396873

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

PMID:12543962[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006471

protein ADP-ribosylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004102
InterPro:IPR008288

P

Seeded From UniProt

complete

GO:0006471

protein ADP-ribosylation

PMID:12183365[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006471

protein ADP-ribosylation

PMID:12543962[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006963

positive regulation of antibacterial peptide biosynthetic process

PMID:12543974[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007000

nucleolus organization

PMID:12183365[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007000

nucleolus organization

PMID:16219773[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007552

metamorphosis

PMID:12543962[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008069

dorsal/ventral axis specification, ovarian follicular epithelium

PMID:24069162[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0004882

P

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001510
InterPro:IPR008288

F

Seeded From UniProt

complete

GO:0009303

rRNA transcription

PMID:12543962[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0015030

Cajal body

PMID:19229318[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016568

chromatin modification

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

GO:0030576

Cajal body organization

PMID:19229318[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035079

polytene chromosome puffing

PMID:12543962[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0035079

polytene chromosome puffing

PMID:15273990[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0035080

heat shock-mediated polytene chromosome puffing

PMID:12543974[5]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0035080

heat shock-mediated polytene chromosome puffing

PMID:12543974[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035363

histone locus body

PMID:19229318[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0042393

histone binding

PMID:17827147[2]

IPI: Inferred from Physical Interaction

FB:FBgn0001196

F

Seeded From UniProt

complete

GO:0042393

histone binding

PMID:17827147[2]

IPI: Inferred from Physical Interaction

FB:FBgn0001198

F

Seeded From UniProt

complete

GO:0042393

histone binding

PMID:17827147[2]

IPI: Inferred from Physical Interaction

FB:FBgn0001199

F

Seeded From UniProt

complete

GO:0042393

histone binding

PMID:17827147[2]

IPI: Inferred from Physical Interaction

FB:FBgn0001200

F

Seeded From UniProt

complete

GO:0043484

regulation of RNA splicing

PMID:19346337[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045087

innate immune response

PMID:12543974[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0048812

neuron projection morphogenesis

PMID:18604272[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051276

chromosome organization

PMID:12543962[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0051287

NAD binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008288

F

Seeded From UniProt

complete

GO:0051457

maintenance of protein location in nucleus

PMID:16219773[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1900182

positive regulation of protein localization to nucleus

PMID:24055367[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Ong, CT et al. (2013) Poly(ADP-ribosyl)ation regulates insulator function and intrachromosomal interactions in Drosophila. Cell 155 148-59 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Pinnola, A et al. (2007) Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity. J. Biol. Chem. 282 32511-9 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Tulin, A et al. (2006) Drosophila poly(ADP-ribose) glycohydrolase mediates chromatin structure and SIR2-dependent silencing. Genetics 172 363-71 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Pirrotta, V (2003) Transcription. Puffing with PARP. Science 299 528-9 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Tulin, A & Spradling, A (2003) Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science 299 560-2 PubMed GONUTS page
  6. 6.0 6.1 6.2 Amé, JC et al. (2004) The PARP superfamily. Bioessays 26 882-93 PubMed GONUTS page
  7. 7.0 7.1 Tulin, A et al. (2002) The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development. Genes Dev. 16 2108-19 PubMed GONUTS page
  8. Costa, A et al. (2013) Rasputin functions as a positive regulator of orb in Drosophila oogenesis. PLoS ONE 8 e72864 PubMed GONUTS page
  9. 9.0 9.1 9.2 Kotova, E et al. (2009) Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. PLoS Genet. 5 e1000387 PubMed GONUTS page
  10. Ji, Y & Tulin, AV (2009) Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing. Nucleic Acids Res. 37 3501-13 PubMed GONUTS page
  11. Sepp, KJ et al. (2008) Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet. 4 e1000111 PubMed GONUTS page