DROME:PARP

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Parp
Protein Name(s)	Poly [ADP-ribose] polymerase PARP NAD(+) ADP-ribosyltransferase ADPRT Poly[ADP-ribose] synthase
External Links
UniProt	P35875
EMBL	D13806 AF051548 AF051544 AF051545 AF051546 AF051547 AF533701 CM000459 BT015238 AY118947
PIR	A47474
RefSeq	NP_001104452.1
UniGene	Dm.7847
ProteinModelPortal	P35875
SMR	P35875
BioGrid	78234
DIP	DIP-23413N
IntAct	P35875
MINT	MINT-836001
PaxDb	P35875
PRIDE	P35875
EnsemblMetazoa	FBtr0113885
GeneID	3355109
KEGG	dme:Dmel_CG40411
CTD	3355109
FlyBase	FBgn0010247
eggNOG	NOG243963
GeneTree	ENSGT00390000017341
InParanoid	P35875
KO	K10798
OMA	DAKVPNW
OrthoDB	EOG7KM5S0
PhylomeDB	P35875
Reactome	REACT_181669
GenomeRNAi	3355109
NextBio	850624
PRO	PR:P35875
Proteomes	UP000000803
Bgee	P35875
GO	GO:0015030 GO:0005694 GO:0035363 GO:0005719 GO:0005730 GO:0005700 GO:0005703 GO:0003677 GO:0042393 GO:0051287 GO:0003950 GO:0008270 GO:0030576 GO:0016568 GO:0051276 GO:0035080 GO:0045087 GO:0051457 GO:0007552 GO:0048812 GO:0007000 GO:0035079 GO:0006963 GO:0006471 GO:0043484 GO:0006355 GO:0009303
Gene3D	1.20.142.10 2.20.140.10 3.30.1740.10 3.40.50.10190 3.90.228.10
InterPro	IPR001357 IPR008288 IPR012982 IPR012317 IPR004102 IPR008893 IPR001510
Pfam	PF00533 PF08063 PF00644 PF02877 PF05406 PF00645
PIRSF	PIRSF000489
SMART	SM00292 SM00773
SUPFAM	SSF142921 SSF47587 SSF52113
PROSITE	PS50172 PS51060 PS51059 PS00347 PS50064

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:1900182	positive regulation of protein localization to nucleus	PMID:24055367^[1]	ECO:0000315			P	Fig 3C	complete CACAO 8989
involved_in	GO:1900182	positive regulation of protein localization to nucleus	PMID:24055367^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:1990404	protein ADP-ribosylase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1340806 PANTHER:PTN000396992 UniProtKB:P09874 UniProtKB:Q9UGN5	F	Seeded From UniProt	complete
involved_in	GO:0070212	protein poly-ADP-ribosylation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1340806 PANTHER:PTN000396992 RGD:2053 UniProtKB:P09874 UniProtKB:P26446 WB:WBGene00004049 WB:WBGene00004050 dictyBase:DDB_G0278741 dictyBase:DDB_G0292820	P	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1340806 MGI:MGI:1891258 PANTHER:PTN000396992 UniProtKB:P09874 UniProtKB:Q9Y6F1 dictyBase:DDB_G0278741 dictyBase:DDB_G0292820	P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010247 MGI:MGI:1340806 MGI:MGI:1341112 PANTHER:PTN000396992 UniProtKB:P09874 UniProtKB:Q9UGN5	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1340806 MGI:MGI:1341112 PANTHER:PTN000396992 RGD:2053 TAIR:locus:2005523 UniProtKB:P09874 UniProtKB:Q9UGN5 dictyBase:DDB_G0278741 dictyBase:DDB_G0279195 dictyBase:DDB_G0292820	C	Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010247 MGI:MGI:1340806 MGI:MGI:1341112 PANTHER:PTN000396992 RGD:2053 TAIR:locus:2042511 UniProtKB:P09874 UniProtKB:Q9Y6F1 WB:WBGene00004049 WB:WBGene00004050	F	Seeded From UniProt	complete
involved_in	GO:0008069	dorsal/ventral axis specification, ovarian follicular epithelium	PMID:24069162^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004882	P	Seeded From UniProt	complete
involved_in	GO:0030576	Cajal body organization	PMID:19229318^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0015030	Cajal body	PMID:19229318^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0035363	histone locus body	PMID:19229318^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:17827147^[5]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0001196	F	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:17827147^[5]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0001200	F	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:17827147^[5]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0001199	F	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:17827147^[5]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0001198	F	Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:17827147^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043484	regulation of RNA splicing	PMID:19346337^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007000	nucleolus organization	PMID:16219773^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:16219773^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:16219773^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051457	maintenance of protein location in nucleus	PMID:16219773^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035080	heat shock-mediated polytene chromosome puffing	PMID:12543974^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035080	heat shock-mediated polytene chromosome puffing	PMID:12543974^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:12543974^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005703	polytene chromosome puff	PMID:12543974^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:12543974^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006963	positive regulation of antibacterial peptide biosynthetic process	PMID:12543974^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005700	polytene chromosome	PMID:12543974^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006471	protein ADP-ribosylation	PMID:12183365^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007000	nucleolus organization	PMID:12183365^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001510 InterPro:IPR008288 InterPro:IPR036957	F	Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004102 InterPro:IPR008288 InterPro:IPR012317 InterPro:IPR036616	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008288	C	Seeded From UniProt	complete
involved_in	GO:0006471	protein ADP-ribosylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004102 InterPro:IPR008288 InterPro:IPR036616	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001510 InterPro:IPR008288 InterPro:IPR036957	F	Seeded From UniProt	complete
enables	GO:0051287	NAD binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008288	F	Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.2.30	F	Seeded From UniProt	complete
part_of	GO:0005700	polytene chromosome	PMID:15273990^[10] PMID:12543962^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:15273990^[10] PMID:12543962^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0035079	polytene chromosome puffing	PMID:15273990^[10] PMID:12543962^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:12543962^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009303	rRNA transcription	PMID:12543962^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006471	protein ADP-ribosylation	PMID:12543962^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007552	metamorphosis	PMID:12543962^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051276	chromosome organization	PMID:12543962^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005703	polytene chromosome puff	PMID:12543962^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ong, CT et al. (2013) Poly(ADP-ribosyl)ation regulates insulator function and intrachromosomal interactions in Drosophila. Cell 155 148-59 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Costa, A et al. (2013) Rasputin functions as a positive regulator of orb in Drosophila oogenesis. PLoS ONE 8 e72864 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Kotova, E et al. (2009) Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. PLoS Genet. 5 e1000387 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Pinnola, A et al. (2007) Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity. J. Biol. Chem. 282 32511-9 PubMed GONUTS page
↑ Ji, Y & Tulin, AV (2009) Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing. Nucleic Acids Res. 37 3501-13 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Tulin, A et al. (2006) Drosophila poly(ADP-ribose) glycohydrolase mediates chromatin structure and SIR2-dependent silencing. Genetics 172 363-71 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Tulin, A & Spradling, A (2003) Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science 299 560-2 PubMed GONUTS page
↑ ^9.0 ^9.1 Tulin, A et al. (2002) The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development. Genes Dev. 16 2108-19 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Amé, JC et al. (2004) The PARP superfamily. Bioessays 26 882-93 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Pirrotta, V (2003) Transcription. Puffing with PARP. Science 299 528-9 PubMed GONUTS page

[PMID:24055367-1] 1.0 ^1.1 Ong, CT et al. (2013) Poly(ADP-ribosyl)ation regulates insulator function and intrachromosomal interactions in Drosophila. Cell 155 148-59 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24069162-3] Costa, A et al. (2013) Rasputin functions as a positive regulator of orb in Drosophila oogenesis. PLoS ONE 8 e72864 PubMed GONUTS page

[PMID:19229318-4] 4.0 ^4.1 ^4.2 Kotova, E et al. (2009) Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. PLoS Genet. 5 e1000387 PubMed GONUTS page

[PMID:17827147-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Pinnola, A et al. (2007) Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity. J. Biol. Chem. 282 32511-9 PubMed GONUTS page

[PMID:19346337-6] Ji, Y & Tulin, AV (2009) Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing. Nucleic Acids Res. 37 3501-13 PubMed GONUTS page

[PMID:16219773-7] 7.0 ^7.1 ^7.2 ^7.3 Tulin, A et al. (2006) Drosophila poly(ADP-ribose) glycohydrolase mediates chromatin structure and SIR2-dependent silencing. Genetics 172 363-71 PubMed GONUTS page

[PMID:12543974-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Tulin, A & Spradling, A (2003) Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science 299 560-2 PubMed GONUTS page

[PMID:12183365-9] 9.0 ^9.1 Tulin, A et al. (2002) The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development. Genes Dev. 16 2108-19 PubMed GONUTS page

[PMID:15273990-10] 10.0 ^10.1 ^10.2 Amé, JC et al. (2004) The PARP superfamily. Bioessays 26 882-93 PubMed GONUTS page

[PMID:12543962-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Pirrotta, V (2003) Transcription. Puffing with PARP. Science 299 528-9 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

DROME:PARP

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

m

n

o

p

r

s

t

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools