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DROME:MTND

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided.
Protein Name(s) 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (ECO:0000255 with HAMAP-Rule:MF_03154)

Acireductone dioxygenase (Fe(2+)-requiring) (ECO:0000255 with HAMAP-Rule:MF_03154) ARD (ECO:0000255 with HAMAP-Rule:MF_03154) Fe-ARD (ECO:0000255 with HAMAP-Rule:MF_03154)

External Links
UniProt Q6AWN0
EMBL AE014296
BT015218
RefSeq NP_001097577.1
UniGene Dm.15417
ProteinModelPortal Q6AWN0
SMR Q6AWN0
BioGrid 77443
IntAct Q6AWN0
MINT MINT-832699
STRING 7227.FBpp0112333
PaxDb Q6AWN0
EnsemblMetazoa FBtr0113421
GeneID 326189
KEGG dme:Dmel_CG32068
UCSC CG32068-RB
FlyBase FBgn0052068
eggNOG COG1791
GeneTree ENSGT00390000008195
InParanoid Q6AWN0
KO K08967
OMA VWIRIWV
OrthoDB EOG73FQP0
PhylomeDB Q6AWN0
Reactome REACT_180809
UniPathway UPA00904
GenomeRNAi 326189
NextBio 847541
PRO PR:Q6AWN0
Proteomes UP000000803
Bgee Q6AWN0
ExpressionAtlas Q6AWN0
GO GO:0005737
GO:0005634
GO:0005886
GO:0010309
GO:0005506
GO:0016491
GO:0019509
Gene3D 2.60.120.10
HAMAP MF_03154
InterPro IPR004313
IPR027496
IPR014710
IPR011051
PANTHER PTHR23418
Pfam PF03079
SUPFAM SSF51182

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0009086

methionine biosynthetic process

PMID:25037729[1]

IMP: Inferred from Mutant Phenotype

P

Figure 5-comparing metabolites produced in wildtype to metabolites produced in Dadi1 mutant.

complete
CACAO 10400

GO:2000243

positive regulation of reproductive process

PMID:25037729[1]

IMP: Inferred from Mutant Phenotype

P

Figure 2a: when flies receive poor nutrition wildtype expressing Dadi1 are more fecund, Figure 2b/c: when Dadi1 introduced to flies not expressing Dadi1, fertility increases

complete
CACAO 10401

GO:2000241

regulation of reproductive process

PMID:25037729[1]

IDA: Inferred from Direct Assay

P

complete
CACAO 10402

GO:0005634

nucleus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9BV57

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9BV57

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9BV57

C

Seeded From UniProt

complete

GO:0006555

methionine metabolic process

PMID:25037729[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008652

cellular amino acid biosynthetic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0028

P

Seeded From UniProt

complete

GO:0009086

methionine biosynthetic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0486

P

Seeded From UniProt

complete

GO:0009086

methionine biosynthetic process

PMID:25037729[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010309

acireductone dioxygenase [iron(II)-requiring] activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004313

F

Seeded From UniProt

complete

GO:0010309

acireductone dioxygenase [iron(II)-requiring] activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.13.11.54

F

Seeded From UniProt

complete

GO:0016491

oxidoreductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027496

F

Seeded From UniProt

complete

GO:0016491

oxidoreductase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9BV57

F

Seeded From UniProt

complete

GO:0016491

oxidoreductase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

GO:0019509

L-methionine biosynthetic process from methylthioadenosine

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027496

P

Seeded From UniProt

complete

GO:0019509

L-methionine biosynthetic process from methylthioadenosine

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9BV57

P

Seeded From UniProt

complete

GO:0019509

L-methionine biosynthetic process from methylthioadenosine

GO_REF:0000041

IEA: Inferred from Electronic Annotation

UniPathway:UPA00904

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0051213

dioxygenase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0223

F

Seeded From UniProt

complete

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004313

P

Seeded From UniProt

complete

GO:0055114

oxidation-reduction process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

GO:2000243

positive regulation of reproductive process

PMID:25037729[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Chou, HY et al. (2014) ADI1, a methionine salvage pathway enzyme, is required for Drosophila fecundity. J. Biomed. Sci. 21 64 PubMed GONUTS page