DROME:LAP4

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	scrib (ECO:0000312 with EMBL:AAF56598.2)
Protein Name(s)	Protein lap4 Protein scribble Protein smell-impaired
External Links
UniProt	Q7KRY7
EMBL	AF190774 AJ252084 AJ271647 AY167903 AY167904 AY167905 AY167906 AE014297 AE014297 AE014297 AE014297 AE014297 AE014297 AE014297 AY069661 BT015240 AY060469
RefSeq	NP_001014669.1 NP_001014670.2 NP_001036761.3 NP_001247318.1 NP_524754.2 NP_733154.1 NP_733155.2 NP_733156.1
UniGene	Dm.16441
ProteinModelPortal	Q7KRY7
SMR	Q7KRY7
BioGrid	69066
IntAct	Q7KRY7
MINT	MINT-1327318
PaxDb	Q7KRY7
PRIDE	Q7KRY7
EnsemblMetazoa	FBtr0308625
GeneID	44448
KEGG	dme:Dmel_CG43398
UCSC	CG5462-RB
CTD	23513
FlyBase	FBgn0263289
eggNOG	COG4886
GeneTree	ENSGT00760000118833
InParanoid	Q7KRY7
KO	K16175
OrthoDB	EOG7JQBMG
PhylomeDB	Q7KRY7
Reactome	REACT_184330
SignaLink	Q7KRY7
ChiTaRS	scrib
GenomeRNAi	44448
NextBio	837278
PRO	PR:Q7KRY7
Proteomes	UP000000803
Bgee	Q7KRY7
ExpressionAtlas	Q7KRY7
GO	GO:0016327 GO:0016323 GO:0005576 GO:0045169 GO:0016328 GO:0031594 GO:0005918 GO:0005923 GO:0005179 GO:0030714 GO:0008105 GO:0060581 GO:0001708 GO:0000902 GO:0008283 GO:0048749 GO:0007391 GO:0045198 GO:0001737 GO:0042067 GO:0035088 GO:0045197 GO:0016332 GO:0016334 GO:0016336 GO:0072002 GO:0001738 GO:0016331 GO:0016333 GO:0016335 GO:0008285 GO:0050680 GO:0045571 GO:0000122 GO:0042048 GO:0030707 GO:0007318 GO:0045823 GO:0007464 GO:0051726 GO:0030100 GO:0042058 GO:0046425 GO:0008593 GO:0050803 GO:0007608 GO:0019991 GO:0048863 GO:0072089 GO:0007472 GO:0045186
Gene3D	2.30.42.10
InterPro	IPR001611 IPR025875 IPR001478
Pfam	PF12799 PF13504 PF13855 PF00595
SMART	SM00228
SUPFAM	SSF50156
PROSITE	PS51450 PS50106

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0042048	olfactory behavior	PMID:12930751^[1]	ECO:0000315			P	Figures 2 & 3	complete CACAO 3462
involved_in	GO:0060581	cell fate commitment involved in pattern specification	PMID:19948068^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	PMID:19948068^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042058	regulation of epidermal growth factor receptor signaling pathway	PMID:19948068^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030714	anterior/posterior axis specification, follicular epithelium	PMID:19948068^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030707	ovarian follicle cell development	PMID:19948068^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008593	regulation of Notch signaling pathway	PMID:19948068^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007318	pole plasm protein localization	PMID:19948068^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	PMID:19948068^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19948068^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0098968	neurotransmitter receptor transport postsynaptic membrane to endosome	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001900149 RGD:1565055	P	Seeded From UniProt	complete
involved_in	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001900149 RGD:1565055	P	Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 UniProtKB:Q12959 UniProtKB:Q14160	P	Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 RGD:68424	P	Seeded From UniProt	complete
colocalizes_with	GO:0045211	postsynaptic membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001900149 UniProtKB:Q14160	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001900149 RGD:708527	C	Seeded From UniProt	complete
involved_in	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1888986 PANTHER:PTN001501163	P	Seeded From UniProt	complete
involved_in	GO:0043113	receptor clustering	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 RGD:619895	P	Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277959 PANTHER:PTN001501163 RGD:2505 RGD:68423 RGD:68424	F	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107231 MGI:MGI:1277959 MGI:MGI:1344351 PANTHER:PTN001501163 UniProtKB:Q12959 UniProtKB:Q14160	C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263289 MGI:MGI:107231 MGI:MGI:2145950 PANTHER:PTN001501163 RGD:2505 UniProtKB:Q12959 WB:WBGene00002632	C	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001900149 RGD:1565055 RGD:708527	C	Seeded From UniProt	complete
colocalizes_with	GO:0008328	ionotropic glutamate receptor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277959 PANTHER:PTN001501163	C	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002508426 UniProtKB:Q14160	C	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002508426 RGD:1565055 UniProtKB:Q14160	C	Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:27263975^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0045169	fusome	PMID:18355804^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	PMID:20432470^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072089	stem cell proliferation	PMID:20432470^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072002	Malpighian tubule development	PMID:20432470^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001737	establishment of imaginal disc-derived wing hair orientation	PMID:19563796^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007464	R3/R4 cell fate commitment	PMID:19563796^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042067	establishment of ommatidial planar polarity	PMID:19563796^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072002	Malpighian tubule development	PMID:19567473^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030100	regulation of endocytosis	PMID:19289090^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	PMID:18070911^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:17082773^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:14681682^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:14681682^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045198	establishment of epithelial cell apical/basal polarity	PMID:14681682^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	PMID:15611336^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048749	compound eye development	PMID:15611336^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007472	wing disc morphogenesis	PMID:15611336^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:15611336^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045571	negative regulation of imaginal disc growth	PMID:15611336^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045186	zonula adherens assembly	PMID:15611336^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019991	septate junction assembly	PMID:15611336^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:15611336^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035088	establishment or maintenance of apical/basal cell polarity	PMID:15611336^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:15302858^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042048	olfactory behavior	PMID:12930751^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:12766944^[15]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045175	basal protein localization	PMID:12545176^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050803	regulation of synapse structure or activity	PMID:12151526^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005918	septate junction	PMID:11700298^[18]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016334	establishment or maintenance of polarity of follicular epithelium	PMID:10884224^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:10884224^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016327	apicolateral plasma membrane	PMID:10884224^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:10884224^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016333	morphogenesis of follicular epithelium	PMID:10884224^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016336	establishment or maintenance of polarity of larval imaginal disc epithelium	PMID:10884224^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016335	morphogenesis of larval imaginal disc epithelium	PMID:10884224^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005918	septate junction	PMID:10688207^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042048	olfactory behavior	PMID:8722782^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:12545176^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:1990794	basolateral part of cell	PMID:25719210^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045571	negative regulation of imaginal disc growth	PMID:29719260^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:14644201^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001738	morphogenesis of a polarized epithelium	PMID:14644201^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	PMID:12766944^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:12766944^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005918	septate junction	PMID:12766944^[15] PMID:12565697^[25] PMID:12141438^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:12147138^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016331	morphogenesis of embryonic epithelium	PMID:10884224^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016332	establishment or maintenance of polarity of embryonic epithelium	PMID:10884224^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0796 UniProtKB-SubCell:SL-0265	C	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0007608	sensory perception of smell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0552	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ganguly, I et al. (2003) Scribble is essential for olfactory behavior in Drosophila melanogaster. Genetics 164 1447-57 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Li, Q et al. (2009) Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis. BMC Dev. Biol. 9 60 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Cervantes-Sandoval, I et al. (2016) Scribble Scaffolds a Signalosome for Active Forgetting. Neuron 90 1230-1242 PubMed GONUTS page
↑ Lighthouse, DV et al. (2008) New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev. Biol. 317 59-71 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Zeng, X et al. (2010) Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules. J. Cell. Physiol. 224 766-74 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Courbard, JR et al. (2009) The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors. Dev. Biol. 333 67-77 PubMed GONUTS page
↑ Campbell, K et al. (2009) Crumbs stabilises epithelial polarity during tissue remodelling. J. Cell. Sci. 122 2604-12 PubMed GONUTS page
↑ Igaki, T et al. (2009) Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev. Cell 16 458-65 PubMed GONUTS page
↑ Kohsaka, H et al. (2007) In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2. J. Cell Biol. 179 1289-300 PubMed GONUTS page
↑ Uhlirova, M & Bohmann, D (2006) JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J. 25 5294-304 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Dow, LE et al. (2003) hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene 22 9225-30 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Zeitler, J et al. (2004) Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. J. Cell Biol. 167 1137-46 PubMed GONUTS page
↑ Sotillos, S et al. (2004) DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J. Cell Biol. 166 549-57 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Humbert, P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25 542-53 PubMed GONUTS page
↑ ^16.0 ^16.1 Albertson, R & Doe, CQ (2003) Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat. Cell Biol. 5 166-70 PubMed GONUTS page
↑ Roche, JP et al. (2002) Regulation of synaptic plasticity and synaptic vesicle dynamics by the PDZ protein Scribble. J. Neurosci. 22 6471-9 PubMed GONUTS page
↑ Tepass, U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35 747-84 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 ^19.8 Bilder, D et al. (2000) Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289 113-6 PubMed GONUTS page
↑ Bilder, D & Perrimon, N (2000) Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403 676-80 PubMed GONUTS page
↑ Anholt, RR et al. (1996) Effects of single P-element insertions on olfactory behavior in Drosophila melanogaster. Genetics 143 293-301 PubMed GONUTS page
↑ Bunker, BD et al. (2015) The transcriptional response to tumorigenic polarity loss in Drosophila. Elife 4 PubMed GONUTS page
↑ Gerlach, SU et al. (2018) Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure. Cell Rep 23 1491-1503 PubMed GONUTS page
↑ ^24.0 ^24.1 Gibson, MC & Perrimon, N (2003) Apicobasal polarization: epithelial form and function. Curr. Opin. Cell Biol. 15 747-52 PubMed GONUTS page
↑ Cereijido, M et al. (2003) Membrane targeting. Prog. Biophys. Mol. Biol. 81 81-115 PubMed GONUTS page
↑ Caruana, G (2002) Genetic studies define MAGUK proteins as regulators of epithelial cell polarity. Int. J. Dev. Biol. 46 511-8 PubMed GONUTS page
↑ Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page

[PMID:12930751-1] 1.0 ^1.1 Ganguly, I et al. (2003) Scribble is essential for olfactory behavior in Drosophila melanogaster. Genetics 164 1447-57 PubMed GONUTS page

[PMID:19948068-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Li, Q et al. (2009) Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis. BMC Dev. Biol. 9 60 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27263975-4] Cervantes-Sandoval, I et al. (2016) Scribble Scaffolds a Signalosome for Active Forgetting. Neuron 90 1230-1242 PubMed GONUTS page

[PMID:18355804-5] Lighthouse, DV et al. (2008) New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev. Biol. 317 59-71 PubMed GONUTS page

[PMID:20432470-6] 6.0 ^6.1 ^6.2 Zeng, X et al. (2010) Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules. J. Cell. Physiol. 224 766-74 PubMed GONUTS page

[PMID:19563796-7] 7.0 ^7.1 ^7.2 Courbard, JR et al. (2009) The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors. Dev. Biol. 333 67-77 PubMed GONUTS page

[PMID:19567473-8] Campbell, K et al. (2009) Crumbs stabilises epithelial polarity during tissue remodelling. J. Cell. Sci. 122 2604-12 PubMed GONUTS page

[PMID:19289090-9] Igaki, T et al. (2009) Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev. Cell 16 458-65 PubMed GONUTS page

[PMID:18070911-10] Kohsaka, H et al. (2007) In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2. J. Cell Biol. 179 1289-300 PubMed GONUTS page

[PMID:17082773-11] Uhlirova, M & Bohmann, D (2006) JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J. 25 5294-304 PubMed GONUTS page

[PMID:14681682-12] 12.0 ^12.1 ^12.2 Dow, LE et al. (2003) hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene 22 9225-30 PubMed GONUTS page

[PMID:15611336-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Zeitler, J et al. (2004) Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. J. Cell Biol. 167 1137-46 PubMed GONUTS page

[PMID:15302858-14] Sotillos, S et al. (2004) DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J. Cell Biol. 166 549-57 PubMed GONUTS page

[PMID:12766944-15] 15.0 ^15.1 ^15.2 ^15.3 Humbert, P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25 542-53 PubMed GONUTS page

[PMID:12545176-16] 16.0 ^16.1 Albertson, R & Doe, CQ (2003) Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat. Cell Biol. 5 166-70 PubMed GONUTS page

[PMID:12151526-17] Roche, JP et al. (2002) Regulation of synaptic plasticity and synaptic vesicle dynamics by the PDZ protein Scribble. J. Neurosci. 22 6471-9 PubMed GONUTS page

[PMID:11700298-18] Tepass, U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35 747-84 PubMed GONUTS page

[PMID:10884224-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 ^19.8 Bilder, D et al. (2000) Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289 113-6 PubMed GONUTS page

[PMID:10688207-20] Bilder, D & Perrimon, N (2000) Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403 676-80 PubMed GONUTS page

[PMID:8722782-21] Anholt, RR et al. (1996) Effects of single P-element insertions on olfactory behavior in Drosophila melanogaster. Genetics 143 293-301 PubMed GONUTS page

[PMID:25719210-22] Bunker, BD et al. (2015) The transcriptional response to tumorigenic polarity loss in Drosophila. Elife 4 PubMed GONUTS page

[PMID:29719260-23] Gerlach, SU et al. (2018) Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure. Cell Rep 23 1491-1503 PubMed GONUTS page

[PMID:14644201-24] 24.0 ^24.1 Gibson, MC & Perrimon, N (2003) Apicobasal polarization: epithelial form and function. Curr. Opin. Cell Biol. 15 747-52 PubMed GONUTS page

[PMID:12565697-25] Cereijido, M et al. (2003) Membrane targeting. Prog. Biophys. Mol. Biol. 81 81-115 PubMed GONUTS page

[PMID:12141438-26] Caruana, G (2002) Genetic studies define MAGUK proteins as regulators of epithelial cell polarity. Int. J. Dev. Biol. 46 511-8 PubMed GONUTS page

[PMID:12147138-27] Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page

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DROME:LAP4

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