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DROME:LAP4

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) scrib (ECO:0000312 with EMBL:AAF56598.2)
Protein Name(s) Protein lap4

Protein scribble Protein smell-impaired

External Links
UniProt Q7KRY7
EMBL AF190774
AJ252084
AJ271647
AY167903
AY167904
AY167905
AY167906
AE014297
AE014297
AE014297
AE014297
AE014297
AE014297
AE014297
AY069661
BT015240
AY060469
RefSeq NP_001014669.1
NP_001014670.2
NP_001036761.3
NP_001247318.1
NP_524754.2
NP_733154.1
NP_733155.2
NP_733156.1
UniGene Dm.16441
ProteinModelPortal Q7KRY7
SMR Q7KRY7
BioGrid 69066
IntAct Q7KRY7
MINT MINT-1327318
PaxDb Q7KRY7
PRIDE Q7KRY7
EnsemblMetazoa FBtr0308625
GeneID 44448
KEGG dme:Dmel_CG43398
UCSC CG5462-RB
CTD 23513
FlyBase FBgn0263289
eggNOG COG4886
GeneTree ENSGT00760000118833
InParanoid Q7KRY7
KO K16175
OrthoDB EOG7JQBMG
PhylomeDB Q7KRY7
Reactome REACT_184330
SignaLink Q7KRY7
ChiTaRS scrib
GenomeRNAi 44448
NextBio 837278
PRO PR:Q7KRY7
Proteomes UP000000803
Bgee Q7KRY7
ExpressionAtlas Q7KRY7
GO GO:0016327
GO:0016323
GO:0005576
GO:0045169
GO:0016328
GO:0031594
GO:0005918
GO:0005923
GO:0005179
GO:0030714
GO:0008105
GO:0060581
GO:0001708
GO:0000902
GO:0008283
GO:0048749
GO:0007391
GO:0045198
GO:0001737
GO:0042067
GO:0035088
GO:0045197
GO:0016332
GO:0016334
GO:0016336
GO:0072002
GO:0001738
GO:0016331
GO:0016333
GO:0016335
GO:0008285
GO:0050680
GO:0045571
GO:0000122
GO:0042048
GO:0030707
GO:0007318
GO:0045823
GO:0007464
GO:0051726
GO:0030100
GO:0042058
GO:0046425
GO:0008593
GO:0050803
GO:0007608
GO:0019991
GO:0048863
GO:0072089
GO:0007472
GO:0045186
Gene3D 2.30.42.10
InterPro IPR001611
IPR025875
IPR001478
Pfam PF12799
PF13504
PF13855
PF00595
SMART SM00228
SUPFAM SSF50156
PROSITE PS51450
PS50106

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0042048

olfactory behavior

PMID:12930751[1]

IMP: Inferred from Mutant Phenotype

P

Figures 2 & 3

complete
CACAO 3462

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:19948068[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000902

cell morphogenesis

PMID:15611336[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001708

cell fate specification

PMID:19948068[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001737

establishment of imaginal disc-derived wing hair orientation

PMID:19563796[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001738

morphogenesis of a polarized epithelium

PMID:14644201[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0005179

hormone activity

PMID:3925062[6]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11937021[7]

IPI: Inferred from Physical Interaction

FB:FBgn0026239

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11937021[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q4AB30

F

Seeded From UniProt

complete

GO:0005576

extracellular region

PMID:3925062[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

GO:0005918

septate junction

PMID:10688207[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005918

septate junction

PMID:11700298[9]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0005918

septate junction

PMID:12141438[10]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005918

septate junction

PMID:12565697[11]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005918

septate junction

PMID:12766944[12]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005923

bicellular tight junction

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0796

C

Seeded From UniProt

complete

GO:0005923

bicellular tight junction

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0265

C

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007318

pole plasm protein localization

PMID:19948068[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:12147138[13]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:15611336[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007399

nervous system development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

GO:0007464

R3/R4 cell fate commitment

PMID:19563796[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007472

wing disc morphogenesis

PMID:15611336[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007608

sensory perception of smell

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0552

P

Seeded From UniProt

complete

GO:0008105

asymmetric protein localization

PMID:12231350[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008105

asymmetric protein localization

PMID:12545176[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008283

cell proliferation

PMID:10884224[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008283

cell proliferation

PMID:17082773[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008285

negative regulation of cell proliferation

PMID:12766944[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008285

negative regulation of cell proliferation

PMID:14681682[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008593

regulation of Notch signaling pathway

PMID:19948068[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016323

basolateral plasma membrane

PMID:14644201[5]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016323

basolateral plasma membrane

PMID:14681682[18]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016323

basolateral plasma membrane

PMID:15302858[19]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016327

apicolateral plasma membrane

PMID:10884224[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016328

lateral plasma membrane

PMID:10884224[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016331

morphogenesis of embryonic epithelium

PMID:10884224[16]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0016332

establishment or maintenance of polarity of embryonic epithelium

PMID:10884224[16]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0016333

morphogenesis of follicular epithelium

PMID:10884224[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016334

establishment or maintenance of polarity of follicular epithelium

PMID:10884224[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016335

morphogenesis of larval imaginal disc epithelium

PMID:10884224[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016336

establishment or maintenance of polarity of larval imaginal disc epithelium

PMID:10884224[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0019991

septate junction assembly

PMID:15611336[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030054

cell junction

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

GO:0030100

regulation of endocytosis

PMID:19289090[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0030707

ovarian follicle cell development

PMID:19948068[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030714

anterior/posterior axis specification, follicular epithelium

PMID:19948068[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031594

neuromuscular junction

PMID:18070911[21]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0035088

establishment or maintenance of apical/basal cell polarity

PMID:15611336[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042048

olfactory behavior

PMID:12930751[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042048

olfactory behavior

PMID:8722782[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042058

regulation of epidermal growth factor receptor signaling pathway

PMID:19948068[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042067

establishment of ommatidial planar polarity

PMID:19563796[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045169

fusome

PMID:18355804[23]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045186

zonula adherens assembly

PMID:15611336[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

PMID:11700298[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

PMID:11782950[24]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

PMID:12766944[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045198

establishment of epithelial cell apical/basal polarity

PMID:14681682[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045571

negative regulation of imaginal disc growth

PMID:15611336[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045823

positive regulation of heart contraction

PMID:3925062[6]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0046425

regulation of JAK-STAT cascade

PMID:19948068[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048749

compound eye development

PMID:15611336[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048863

stem cell differentiation

PMID:20432470[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050680

negative regulation of epithelial cell proliferation

PMID:15611336[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050803

regulation of synapse structure or activity

PMID:12151526[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050896

response to stimulus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

GO:0051726

regulation of cell cycle

PMID:12766944[12]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0060581

cell fate commitment involved in pattern specification

PMID:19948068[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0072002

Malpighian tubule development

PMID:19567473[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0072002

Malpighian tubule development

PMID:20432470[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0072089

stem cell proliferation

PMID:20432470[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Ganguly, I et al. (2003) Scribble is essential for olfactory behavior in Drosophila melanogaster. Genetics 164 1447-57 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Li, Q et al. (2009) Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis. BMC Dev. Biol. 9 60 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Zeitler, J et al. (2004) Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. J. Cell Biol. 167 1137-46 PubMed GONUTS page
  4. 4.0 4.1 4.2 Courbard, JR et al. (2009) The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors. Dev. Biol. 333 67-77 PubMed GONUTS page
  5. 5.0 5.1 Gibson, MC & Perrimon, N (2003) Apicobasal polarization: epithelial form and function. Curr. Opin. Cell Biol. 15 747-52 PubMed GONUTS page
  6. 6.0 6.1 6.2 Tublitz, NJ & Truman, JW (1985) Insect cardioactive peptides. I. Distribution and molecular characteristics of two cardioacceleratory peptides in the tobacco hawkmoth, Manduca sexta. J. Exp. Biol. 114 365-79 PubMed GONUTS page
  7. 7.0 7.1 Mathew, D et al. (2002) Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Curr. Biol. 12 531-9 PubMed GONUTS page
  8. Bilder, D & Perrimon, N (2000) Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403 676-80 PubMed GONUTS page
  9. 9.0 9.1 Tepass, U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35 747-84 PubMed GONUTS page
  10. Caruana, G (2002) Genetic studies define MAGUK proteins as regulators of epithelial cell polarity. Int. J. Dev. Biol. 46 511-8 PubMed GONUTS page
  11. Cereijido, M et al. (2003) Membrane targeting. Prog. Biophys. Mol. Biol. 81 81-115 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 Humbert, P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25 542-53 PubMed GONUTS page
  13. Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
  14. Wedlich, D (2002) The polarising role of cell adhesion molecules in early development. Curr. Opin. Cell Biol. 14 563-8 PubMed GONUTS page
  15. Albertson, R & Doe, CQ (2003) Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat. Cell Biol. 5 166-70 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 16.4 16.5 16.6 16.7 16.8 Bilder, D et al. (2000) Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289 113-6 PubMed GONUTS page
  17. Uhlirova, M & Bohmann, D (2006) JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J. 25 5294-304 PubMed GONUTS page
  18. 18.0 18.1 18.2 Dow, LE et al. (2003) hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene 22 9225-30 PubMed GONUTS page
  19. Sotillos, S et al. (2004) DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J. Cell Biol. 166 549-57 PubMed GONUTS page
  20. Igaki, T et al. (2009) Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev. Cell 16 458-65 PubMed GONUTS page
  21. Kohsaka, H et al. (2007) In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2. J. Cell Biol. 179 1289-300 PubMed GONUTS page
  22. Anholt, RR et al. (1996) Effects of single P-element insertions on olfactory behavior in Drosophila melanogaster. Genetics 143 293-301 PubMed GONUTS page
  23. Lighthouse, DV et al. (2008) New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev. Biol. 317 59-71 PubMed GONUTS page
  24. Johnston, LA & Gallant, P (2002) Control of growth and organ size in Drosophila. Bioessays 24 54-64 PubMed GONUTS page
  25. 25.0 25.1 25.2 Zeng, X et al. (2010) Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules. J. Cell. Physiol. 224 766-74 PubMed GONUTS page
  26. Roche, JP et al. (2002) Regulation of synaptic plasticity and synaptic vesicle dynamics by the PDZ protein Scribble. J. Neurosci. 22 6471-9 PubMed GONUTS page
  27. Campbell, K et al. (2009) Crumbs stabilises epithelial polarity during tissue remodelling. J. Cell. Sci. 122 2604-12 PubMed GONUTS page