PMID:19948068

Citation	Li, Q, Shen, L, Xin, T, Xiang, W, Chen, W, Gao, Y, Zhu, M, Yu, L and Li, M (2009) Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis. BMC Dev. Biol. 9:60
Abstract	Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning.
Links	PubMed PMC2810132 Online version:10.1186/1471-213X-9-60
Keywords	Animals; Body Patterning/genetics; Body Patterning/physiology; Cell Differentiation/genetics; Cell Differentiation/physiology; Drosophila; Drosophila Proteins/genetics; Drosophila Proteins/physiology; Epithelium/embryology; Epithelium/metabolism; Female; Membrane Proteins/genetics; Membrane Proteins/physiology; Oogenesis/genetics; Oogenesis/physiology; Ovarian Follicle/cytology; Ovarian Follicle/embryology; Ovarian Follicle/metabolism; Signal Transduction/genetics; Signal Transduction/physiology; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/physiology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
DROME:STAU	located_in	GO:0060293: germ plasm	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
DROME:DLG1	involved_in	GO:0030714: anterior/posterior axis specification, follicular epithelium	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:DLG1	involved_in	GO:0030707: ovarian follicle cell development	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:DLG1	involved_in	GO:0042058: regulation of epidermal growth factor receptor signaling pathway	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:DLG1	involved_in	GO:0007318: pole plasm protein localization	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:DLG1	involved_in	GO:0001708: cell fate specification	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:DLG1	involved_in	GO:0060581: cell fate commitment involved in pattern specification	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:STAT	located_in	GO:0005634: nucleus	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
DROME:SCRIB	involved_in	GO:0030714: anterior/posterior axis specification, follicular epithelium	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:SCRIB	involved_in	GO:0030707: ovarian follicle cell development	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:SCRIB	involved_in	GO:0007318: pole plasm protein localization	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:SCRIB	involved_in	GO:0001708: cell fate specification	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:SCRIB	involved_in	GO:0060581: cell fate commitment involved in pattern specification	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:LAP4	involved_in	GO:0060581: cell fate commitment involved in pattern specification	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:LAP4	involved_in	GO:0000122: negative regulation of transcription by RNA polymerase II	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:LAP4	involved_in	GO:0046425: regulation of receptor signaling pathway via JAK-STAT	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:LAP4	involved_in	GO:0042058: regulation of epidermal growth factor receptor signaling pathway	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:LAP4	involved_in	GO:0030714: anterior/posterior axis specification, follicular epithelium	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:LAP4	involved_in	GO:0030707: ovarian follicle cell development	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:LAP4	involved_in	GO:0008593: regulation of Notch signaling pathway	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:LAP4	involved_in	GO:0007318: pole plasm protein localization	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:LAP4	involved_in	GO:0001708: cell fate specification	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

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