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PMID:19948068

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Citation

Li, Q, Shen, L, Xin, T, Xiang, W, Chen, W, Gao, Y, Zhu, M, Yu, L and Li, M (2009) Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis. BMC Dev. Biol. 9:60

Abstract

Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning.

Links

PubMed PMC2810132 Online version:10.1186/1471-213X-9-60

Keywords

Animals; Body Patterning/genetics; Body Patterning/physiology; Cell Differentiation/genetics; Cell Differentiation/physiology; Drosophila; Drosophila Proteins/genetics; Drosophila Proteins/physiology; Epithelium/embryology; Epithelium/metabolism; Female; Membrane Proteins/genetics; Membrane Proteins/physiology; Oogenesis/genetics; Oogenesis/physiology; Ovarian Follicle/cytology; Ovarian Follicle/embryology; Ovarian Follicle/metabolism; Signal Transduction/genetics; Signal Transduction/physiology; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:STAU

located_in

GO:0060293: germ plasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:DLG1

involved_in

GO:0030714: anterior/posterior axis specification, follicular epithelium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DLG1

involved_in

GO:0030707: ovarian follicle cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DLG1

involved_in

GO:0042058: regulation of epidermal growth factor receptor signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DLG1

involved_in

GO:0007318: pole plasm protein localization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DLG1

involved_in

GO:0001708: cell fate specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DLG1

involved_in

GO:0060581: cell fate commitment involved in pattern specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:STAT

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:SCRIB

involved_in

GO:0030714: anterior/posterior axis specification, follicular epithelium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:SCRIB

involved_in

GO:0030707: ovarian follicle cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:SCRIB

involved_in

GO:0007318: pole plasm protein localization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:SCRIB

involved_in

GO:0001708: cell fate specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:SCRIB

involved_in

GO:0060581: cell fate commitment involved in pattern specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:LAP4

involved_in

GO:0060581: cell fate commitment involved in pattern specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:LAP4

involved_in

GO:0000122: negative regulation of transcription by RNA polymerase II

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:LAP4

involved_in

GO:0046425: regulation of receptor signaling pathway via JAK-STAT

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:LAP4

involved_in

GO:0042058: regulation of epidermal growth factor receptor signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:LAP4

involved_in

GO:0030714: anterior/posterior axis specification, follicular epithelium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:LAP4

involved_in

GO:0030707: ovarian follicle cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:LAP4

involved_in

GO:0008593: regulation of Notch signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:LAP4

involved_in

GO:0007318: pole plasm protein localization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:LAP4

involved_in

GO:0001708: cell fate specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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