It is now the 5th OPEN Period for CACAO Fall 2017! It will end on Sunday November 19, 2017 at 11:59 pm CST
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

DROME:LAMC

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) LamC
Protein Name(s) Lamin-C

pG-IF

External Links
UniProt Q03427
EMBL L07933
X75886
AE013599
AY095046
PIR S49020
RefSeq NP_523742.2
UniGene Dm.2782
ProteinModelPortal Q03427
SMR Q03427
BioGrid 62363
MINT MINT-1329471
PaxDb Q03427
EnsemblMetazoa FBtr0087512
GeneID 36615
KEGG dme:Dmel_CG10119
CTD 36615
FlyBase FBgn0010397
eggNOG NOG325506
GeneTree ENSGT00760000118905
InParanoid Q03427
KO K07611
OrthoDB EOG7MD4PW
PhylomeDB Q03427
Reactome REACT_180717
REACT_219169
REACT_249949
GenomeRNAi 36615
NextBio 799505
Proteomes UP000000803
Bgee Q03427
GO GO:0005638
GO:0005637
GO:0005652
GO:0034399
GO:0070732
GO:0005198
GO:0006325
GO:0006342
GO:0060415
GO:0031081
GO:0030833
GO:0035989
Gene3D 2.60.40.1260
InterPro IPR001664
IPR027696
IPR001322
PANTHER PTHR23239
PTHR23239:SF142
Pfam PF00038
PF00932
SUPFAM SSF74853

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005198

structural molecule activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001664

F

Seeded From UniProt

complete

GO:0005198

structural molecule activity

PMID:20702563[1]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005637

nuclear inner membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027696

C

Seeded From UniProt

complete

GO:0005638

lamin filament

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027696

C

Seeded From UniProt

complete

GO:0005638

lamin filament

PMID:9372441[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005638

lamin filament

PMID:9665133[3]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0005652

nuclear lamina

PMID:7593280[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005882

intermediate filament

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001664

C

Seeded From UniProt

complete

GO:0005882

intermediate filament

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0403

C

Seeded From UniProt

complete

GO:0006325

chromatin organization

PMID:20505245[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006342

chromatin silencing

PMID:20702563[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030833

regulation of actin filament polymerization

PMID:20702563[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031081

nuclear pore distribution

PMID:19855837[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031081

nuclear pore distribution

PMID:20702563[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034399

nuclear periphery

PMID:20702563[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0035989

tendon development

PMID:22982669[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060415

muscle tissue morphogenesis

PMID:20702563[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0070732

spindle envelope

PMID:18562695[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

colocalizes_with

GO:0005635

nuclear envelope

PMID:15546914[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Dialynas, G et al. (2010) The role of Drosophila Lamin C in muscle function and gene expression. Development 137 3067-77 PubMed GONUTS page
  2. Klapper, M et al. (1997) Assembly of A- and B-type lamins studied in vivo with the baculovirus system. J. Cell. Sci. 110 ( Pt 20) 2519-32 PubMed GONUTS page
  3. Bellaiche, Y et al. (1998) Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature 394 85-8 PubMed GONUTS page
  4. Riemer, D et al. (1995) Expression of Drosophila lamin C is developmentally regulated: analogies with vertebrate A-type lamins. J. Cell. Sci. 108 ( Pt 10) 3189-98 PubMed GONUTS page
  5. Gurudatta, BV et al. (2010) Lamin C and chromatin organization in Drosophila. J. Genet. 89 37-49 PubMed GONUTS page
  6. Schulze, SR et al. (2009) A comparative study of Drosophila and human A-type lamins. PLoS ONE 4 e7564 PubMed GONUTS page
  7. Uchino, R et al. (2013) Loss of Drosophila A-type lamin C initially causes tendon abnormality including disintegration of cytoskeleton and nuclear lamina in muscular defects. Dev. Biol. 373 216-27 PubMed GONUTS page
  8. Katsani, KR et al. (2008) In vivo dynamics of Drosophila nuclear envelope components. Mol. Biol. Cell 19 3652-66 PubMed GONUTS page
  9. Prüfert, K et al. (2004) The lamin CxxM motif promotes nuclear membrane growth. J. Cell. Sci. 117 6105-16 PubMed GONUTS page