DROME:ITA3

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	scb (synonyms: alphaPS3, Vol)
Protein Name(s)	Integrin alpha-PS3 Position-specific antigen subunit alpha-3 Protein scab Protein volado Integrin alpha-PS3 heavy chain Integrin alpha-PS3 light chain
External Links
UniProt	O44386
EMBL	U76605 AF034199 AF034200 AE013599 AE013599 BT015245 BT021944
PIR	T09403 T09433
RefSeq	NP_523750.2 NP_725445.1
UniGene	Dm.636
ProteinModelPortal	O44386
SMR	O44386
BioGrid	62429
IntAct	O44386
MINT	MINT-1552140
PaxDb	O44386
PRIDE	O44386
EnsemblMetazoa	FBtr0087369
GeneID	36692
KEGG	dme:Dmel_CG8095
CTD	20242
FlyBase	FBgn0003328
eggNOG	NOG295779
GeneTree	ENSGT00760000118782
InParanoid	O44386
OMA	STGCATD
OrthoDB	EOG70ZZMK
PhylomeDB	O44386
Reactome	REACT_180315 REACT_184300 REACT_184379 REACT_202927 REACT_211028 REACT_242620 REACT_258774
ChiTaRS	scrib
GenomeRNAi	36692
NextBio	799887
PRO	PR:O44386
Proteomes	UP000000803
Bgee	O44386
GO	GO:0016324 GO:0009925 GO:0005737 GO:0005925 GO:0008305 GO:0016328 GO:0005886 GO:0050839 GO:0005178 GO:0046982 GO:0004872 GO:0005198 GO:0043277 GO:0007411 GO:0048149 GO:0016339 GO:0016340 GO:0007155 GO:0016477 GO:0007160 GO:0007391 GO:0035001 GO:0007157 GO:0007229 GO:0007508 GO:0007611 GO:0040011 GO:0007613 GO:0007494 GO:0030336 GO:0045886 GO:0008355 GO:0001555 GO:0003344 GO:0006909 GO:0007431 GO:0007614 GO:0042060
InterPro	IPR013517 IPR013519 IPR000413 IPR013649 IPR018184
Pfam	PF01839 PF08441
PRINTS	PR01185
SMART	SM00191
PROSITE	PS51470 PS00242

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0030336	negative regulation of cell migration	PMID:19035354^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000579)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:19035354^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	PMID:19035354^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19035354^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001555	oocyte growth	PMID:19035354^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:23426364^[2]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0010395	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:23426364^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0008305	integrin complex	PMID:23426364^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043277	apoptotic cell clearance	PMID:23426364^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	PMID:23426364^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007508	larval heart development	PMID:22353787^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	PMID:19951294^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:19884309^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045886	negative regulation of synaptic growth at neuromuscular junction	PMID:18925939^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0020440	P		Seeded From UniProt	complete
involved_in	GO:0033627	cell adhesion mediated by integrin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	FB:FBgn0004657	P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:17034783^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:16516189^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0008305	integrin complex	PMID:14519396^[9]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:12040052^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:11715043^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040011	locomotion	PMID:11715043^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:11462211^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008355	olfactory learning	PMID:11462211^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016340	calcium-dependent cell-matrix adhesion	PMID:10908592^[13]	ECO:0000250	sequence similarity evidence used in manual assertion		P		Seeded From UniProt	Missing: with/from
part_of	GO:0008305	integrin complex	PMID:10908592^[13]	ECO:0000250	sequence similarity evidence used in manual assertion		C		Seeded From UniProt	Missing: with/from
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:10908592^[13]	ECO:0000250	sequence similarity evidence used in manual assertion		P		Seeded From UniProt	Missing: with/from
part_of	GO:0005925	focal adhesion	PMID:10908592^[13]	ECO:0000250	sequence similarity evidence used in manual assertion		C		Seeded From UniProt	Missing: with/from
part_of	GO:0008305	integrin complex	PMID:10936444^[14]	ECO:0000250	sequence similarity evidence used in manual assertion		C		Seeded From UniProt	Missing: with/from
part_of	GO:0008305	integrin complex	PMID:10449347^[15]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007431	salivary gland development	PMID:9409675^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9409675^[16]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0004657	F		Seeded From UniProt	complete
involved_in	GO:0035001	dorsal trunk growth, open tracheal system	PMID:9409675^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9409675^[16]	ECO:0000250	sequence similarity evidence used in manual assertion		C		Seeded From UniProt	Missing: with/from
part_of	GO:0008305	integrin complex	PMID:9409675^[16]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0004657	C		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:9409675^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003344	pericardium morphogenesis	PMID:9409675^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000413	P		Seeded From UniProt	complete
part_of	GO:0008305	integrin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000413	C		Seeded From UniProt	complete
involved_in	GO:0007614	short-term memory	PMID:11741030^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:12147138^[18] PMID:10491260^[19] PMID:10449347^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:11703918^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007160	cell-matrix adhesion	PMID:10908592^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:10908592^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007494	midgut development	PMID:10936444^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:10936444^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0401	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0581	P		Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0896	P		Seeded From UniProt	complete
involved_in	GO:0007610	behavior	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0085	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0153	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Dinkins, MB et al. (2008) Integrin alpha chains exhibit distinct temporal and spatial localization patterns in epithelial cells of the Drosophila ovary. Dev. Dyn. 237 3927-39 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Nonaka, S et al. (2013) Integrin αPS3/βν-mediated phagocytosis of apoptotic cells and bacteria in Drosophila. J. Biol. Chem. 288 10374-80 PubMed GONUTS page
↑ Vanderploeg, J et al. (2012) Integrins are required for cardioblast polarisation in Drosophila. BMC Dev. Biol. 12 8 PubMed GONUTS page
↑ Kong, EC et al. (2010) Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Alcohol. Clin. Exp. Res. 34 302-16 PubMed GONUTS page
↑ Campos, I et al. (2010) Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Genetics 184 129-40 PubMed GONUTS page
↑ Tsai, PI et al. (2008) Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth. Neural Dev 3 26 PubMed GONUTS page
↑ Wada, A et al. (2007) Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in Drosophila. Dev. Biol. 301 340-9 PubMed GONUTS page
↑ MacMullin, A & Jacobs, JR (2006) Slit coordinates cardiac morphogenesis in Drosophila. Dev. Biol. 293 154-64 PubMed GONUTS page
↑ Brower, DL (2003) Platelets with wings: the maturation of Drosophila integrin biology. Curr. Opin. Cell Biol. 15 607-13 PubMed GONUTS page
↑ Stevens, A & Jacobs, JR (2002) Integrins regulate responsiveness to slit repellent signals. J. Neurosci. 22 4448-55 PubMed GONUTS page
↑ ^11.0 ^11.1 Sokolowski, MB (2001) Drosophila: genetics meets behaviour. Nat. Rev. Genet. 2 879-90 PubMed GONUTS page
↑ ^12.0 ^12.1 Roman, G & Davis, RL (2001) Molecular biology and anatomy of Drosophila olfactory associative learning. Bioessays 23 571-81 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Hynes, RO & Zhao, Q (2000) The evolution of cell adhesion. J. Cell Biol. 150 F89-96 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Brown, NH (2000) Cell-cell adhesion via the ECM: integrin genetics in fly and worm. Matrix Biol. 19 191-201 PubMed GONUTS page
↑ ^15.0 ^15.1 Noselli, S & Agnès, F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr. Opin. Genet. Dev. 9 466-72 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Stark, KA et al. (1997) A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development. Development 124 4583-94 PubMed GONUTS page
↑ Burrell, BD & Sahley, CL (2001) Learning in simple systems. Curr. Opin. Neurobiol. 11 757-64 PubMed GONUTS page
↑ Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
↑ Lamka, ML & Lipshitz, HD (1999) Role of the amnioserosa in germ band retraction of the Drosophila melanogaster embryo. Dev. Biol. 214 102-12 PubMed GONUTS page
↑ Waddell, S & Quinn, WG (2001) Fas-acting memory. Dev. Cell 1 8-9 PubMed GONUTS page

[PMID:19035354-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Dinkins, MB et al. (2008) Integrin alpha chains exhibit distinct temporal and spatial localization patterns in epithelial cells of the Drosophila ovary. Dev. Dyn. 237 3927-39 PubMed GONUTS page

[PMID:23426364-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Nonaka, S et al. (2013) Integrin αPS3/βν-mediated phagocytosis of apoptotic cells and bacteria in Drosophila. J. Biol. Chem. 288 10374-80 PubMed GONUTS page

[PMID:22353787-3] Vanderploeg, J et al. (2012) Integrins are required for cardioblast polarisation in Drosophila. BMC Dev. Biol. 12 8 PubMed GONUTS page

[PMID:19951294-4] Kong, EC et al. (2010) Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Alcohol. Clin. Exp. Res. 34 302-16 PubMed GONUTS page

[PMID:19884309-5] Campos, I et al. (2010) Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Genetics 184 129-40 PubMed GONUTS page

[PMID:18925939-6] Tsai, PI et al. (2008) Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth. Neural Dev 3 26 PubMed GONUTS page

[PMID:17034783-7] Wada, A et al. (2007) Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in Drosophila. Dev. Biol. 301 340-9 PubMed GONUTS page

[PMID:16516189-8] MacMullin, A & Jacobs, JR (2006) Slit coordinates cardiac morphogenesis in Drosophila. Dev. Biol. 293 154-64 PubMed GONUTS page

[PMID:14519396-9] Brower, DL (2003) Platelets with wings: the maturation of Drosophila integrin biology. Curr. Opin. Cell Biol. 15 607-13 PubMed GONUTS page

[PMID:12040052-10] Stevens, A & Jacobs, JR (2002) Integrins regulate responsiveness to slit repellent signals. J. Neurosci. 22 4448-55 PubMed GONUTS page

[PMID:11715043-11] 11.0 ^11.1 Sokolowski, MB (2001) Drosophila: genetics meets behaviour. Nat. Rev. Genet. 2 879-90 PubMed GONUTS page

[PMID:11462211-12] 12.0 ^12.1 Roman, G & Davis, RL (2001) Molecular biology and anatomy of Drosophila olfactory associative learning. Bioessays 23 571-81 PubMed GONUTS page

[PMID:10908592-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Hynes, RO & Zhao, Q (2000) The evolution of cell adhesion. J. Cell Biol. 150 F89-96 PubMed GONUTS page

[PMID:10936444-14] 14.0 ^14.1 ^14.2 Brown, NH (2000) Cell-cell adhesion via the ECM: integrin genetics in fly and worm. Matrix Biol. 19 191-201 PubMed GONUTS page

[PMID:10449347-15] 15.0 ^15.1 Noselli, S & Agnès, F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr. Opin. Genet. Dev. 9 466-72 PubMed GONUTS page

[PMID:9409675-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Stark, KA et al. (1997) A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development. Development 124 4583-94 PubMed GONUTS page

[PMID:11741030-17] Burrell, BD & Sahley, CL (2001) Learning in simple systems. Curr. Opin. Neurobiol. 11 757-64 PubMed GONUTS page

[PMID:12147138-18] Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page

[PMID:10491260-19] Lamka, ML & Lipshitz, HD (1999) Role of the amnioserosa in germ band retraction of the Drosophila melanogaster embryo. Dev. Biol. 214 102-12 PubMed GONUTS page

[PMID:11703918-20] Waddell, S & Quinn, WG (2001) Fas-acting memory. Dev. Cell 1 8-9 PubMed GONUTS page

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DROME:ITA3

Contents

Annotations

Notes

References

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