GONUTS has been updated to MW1.29.2. Most things seem to be working but be sure to report problems.

It is now the 6th OPEN Period for CACAO Spring 2018! It will end on Monday April 23, 2018 at 05:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

It is now the 4th OPEN Period for CACAO Phage Hunters 2018! It will end on Sunday April 22, 2018 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

DROME:ITA3

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) scb (synonyms: alphaPS3, Vol)
Protein Name(s) Integrin alpha-PS3

Position-specific antigen subunit alpha-3 Protein scab Protein volado Integrin alpha-PS3 heavy chain Integrin alpha-PS3 light chain

External Links
UniProt O44386
EMBL U76605
AF034199
AF034200
AE013599
AE013599
BT015245
BT021944
PIR T09403
T09433
RefSeq NP_523750.2
NP_725445.1
UniGene Dm.636
ProteinModelPortal O44386
SMR O44386
BioGrid 62429
IntAct O44386
MINT MINT-1552140
PaxDb O44386
PRIDE O44386
EnsemblMetazoa FBtr0087369
GeneID 36692
KEGG dme:Dmel_CG8095
CTD 20242
FlyBase FBgn0003328
eggNOG NOG295779
GeneTree ENSGT00760000118782
InParanoid O44386
OMA STGCATD
OrthoDB EOG70ZZMK
PhylomeDB O44386
Reactome REACT_180315
REACT_184300
REACT_184379
REACT_202927
REACT_211028
REACT_242620
REACT_258774
ChiTaRS scrib
GenomeRNAi 36692
NextBio 799887
PRO PR:O44386
Proteomes UP000000803
Bgee O44386
GO GO:0016324
GO:0009925
GO:0005737
GO:0005925
GO:0008305
GO:0016328
GO:0005886
GO:0050839
GO:0005178
GO:0046982
GO:0004872
GO:0005198
GO:0043277
GO:0007411
GO:0048149
GO:0016339
GO:0016340
GO:0007155
GO:0016477
GO:0007160
GO:0007391
GO:0035001
GO:0007157
GO:0007229
GO:0007508
GO:0007611
GO:0040011
GO:0007613
GO:0007494
GO:0030336
GO:0045886
GO:0008355
GO:0001555
GO:0003344
GO:0006909
GO:0007431
GO:0007614
GO:0042060
InterPro IPR013517
IPR013519
IPR000413
IPR013649
IPR018184
Pfam PF01839
PF08441
PRINTS PR01185
SMART SM00191
PROSITE PS51470
PS00242

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001555

oocyte growth

PMID:19035354[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003344

pericardium morphogenesis

PMID:9409675[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0004872

receptor activity

PMID:10908592[3]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0004872

receptor activity

PMID:9461212[4]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:19035354[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:9409675[2]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005925

focal adhesion

PMID:10908592[3]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0006909

phagocytosis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0581

P

Seeded From UniProt

complete

GO:0006909

phagocytosis

PMID:16336044[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006909

phagocytosis

PMID:23426364[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000413

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

PMID:9461212[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

PMID:10908592[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007160

cell-matrix adhesion

PMID:10908592[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007229

integrin-mediated signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0401

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:10449347[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:10491260[8]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:12000787[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:12147138[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:16516189[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:17034783[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:9409675[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:12040052[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007431

salivary gland development

PMID:9409675[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007494

midgut development

PMID:10936444[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007508

larval heart development

PMID:22353787[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007610

behavior

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0085

P

Seeded From UniProt

complete

GO:0007611

learning or memory

PMID:11715043[16]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007613

memory

PMID:11462211[17]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007613

memory

PMID:11703918[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007614

short-term memory

PMID:11741030[19]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008305

integrin complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000413

C

Seeded From UniProt

complete

GO:0008305

integrin complex

PMID:10449347[7]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0008305

integrin complex

PMID:10908592[3]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0008305

integrin complex

PMID:10936444[14]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0008305

integrin complex

PMID:14519396[20]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0008305

integrin complex

PMID:23426364[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0008305

integrin complex

PMID:9409675[2]

IPI: Inferred from Physical Interaction

FB:FBgn0004657

C

Seeded From UniProt

complete

GO:0008305

integrin complex

PMID:9461212[4]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0008355

olfactory learning

PMID:11462211[17]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0009925

basal plasma membrane

PMID:19035354[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

PMID:23426364[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016324

apical plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0015

C

Seeded From UniProt

complete

GO:0016324

apical plasma membrane

PMID:19035354[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016328

lateral plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0153

C

Seeded From UniProt

complete

GO:0016339

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

PMID:10908592[3]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0016340

calcium-dependent cell-matrix adhesion

PMID:10908592[3]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0016477

cell migration

PMID:10936444[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0030336

negative regulation of cell migration

PMID:19035354[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0033627

cell adhesion mediated by integrin

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0004657

P

Seeded From UniProt

complete

GO:0035001

dorsal trunk growth, open tracheal system

PMID:9409675[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040011

locomotion

PMID:11715043[16]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0042060

wound healing

PMID:19884309[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043277

apoptotic cell clearance

PMID:23426364[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045886

negative regulation of synaptic growth at neuromuscular junction

PMID:18925939[22]

IGI: Inferred from Genetic Interaction

FB:FBgn0020440

P

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:23426364[6]

IPI: Inferred from Physical Interaction

FB:FBgn0010395

F

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:9409675[2]

IPI: Inferred from Physical Interaction

FB:FBgn0004657

F

Seeded From UniProt

complete

GO:0048149

behavioral response to ethanol

PMID:19951294[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048477

oogenesis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0896

P

Seeded From UniProt

complete

GO:0050839

cell adhesion molecule binding

PMID:10908592[3]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0050839

cell adhesion molecule binding

PMID:9461212[4]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Dinkins, MB et al. (2008) Integrin alpha chains exhibit distinct temporal and spatial localization patterns in epithelial cells of the Drosophila ovary. Dev. Dyn. 237 3927-39 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Stark, KA et al. (1997) A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development. Development 124 4583-94 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Hynes, RO & Zhao, Q (2000) The evolution of cell adhesion. J. Cell Biol. 150 F89-96 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Grotewiel, MS et al. (1998) Integrin-mediated short-term memory in Drosophila. Nature 391 455-60 PubMed GONUTS page
  5. Stroschein-Stevenson, SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol. 4 e4 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Nonaka, S et al. (2013) Integrin αPS3/βν-mediated phagocytosis of apoptotic cells and bacteria in Drosophila. J. Biol. Chem. 288 10374-80 PubMed GONUTS page
  7. 7.0 7.1 Noselli, S & Agnès, F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr. Opin. Genet. Dev. 9 466-72 PubMed GONUTS page
  8. Lamka, ML & Lipshitz, HD (1999) Role of the amnioserosa in germ band retraction of the Drosophila melanogaster embryo. Dev. Biol. 214 102-12 PubMed GONUTS page
  9. Van Aelst, L & Symons, M (2002) Role of Rho family GTPases in epithelial morphogenesis. Genes Dev. 16 1032-54 PubMed GONUTS page
  10. Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
  11. MacMullin, A & Jacobs, JR (2006) Slit coordinates cardiac morphogenesis in Drosophila. Dev. Biol. 293 154-64 PubMed GONUTS page
  12. Wada, A et al. (2007) Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in Drosophila. Dev. Biol. 301 340-9 PubMed GONUTS page
  13. Stevens, A & Jacobs, JR (2002) Integrins regulate responsiveness to slit repellent signals. J. Neurosci. 22 4448-55 PubMed GONUTS page
  14. 14.0 14.1 14.2 Brown, NH (2000) Cell-cell adhesion via the ECM: integrin genetics in fly and worm. Matrix Biol. 19 191-201 PubMed GONUTS page
  15. Vanderploeg, J et al. (2012) Integrins are required for cardioblast polarisation in Drosophila. BMC Dev. Biol. 12 8 PubMed GONUTS page
  16. 16.0 16.1 Sokolowski, MB (2001) Drosophila: genetics meets behaviour. Nat. Rev. Genet. 2 879-90 PubMed GONUTS page
  17. 17.0 17.1 Roman, G & Davis, RL (2001) Molecular biology and anatomy of Drosophila olfactory associative learning. Bioessays 23 571-81 PubMed GONUTS page
  18. Waddell, S & Quinn, WG (2001) Fas-acting memory. Dev. Cell 1 8-9 PubMed GONUTS page
  19. Burrell, BD & Sahley, CL (2001) Learning in simple systems. Curr. Opin. Neurobiol. 11 757-64 PubMed GONUTS page
  20. Brower, DL (2003) Platelets with wings: the maturation of Drosophila integrin biology. Curr. Opin. Cell Biol. 15 607-13 PubMed GONUTS page
  21. Campos, I et al. (2010) Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Genetics 184 129-40 PubMed GONUTS page
  22. Tsai, PI et al. (2008) Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth. Neural Dev 3 26 PubMed GONUTS page
  23. Kong, EC et al. (2010) Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Alcohol. Clin. Exp. Res. 34 302-16 PubMed GONUTS page