DROME:GBLP

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Rack1
Protein Name(s)	Guanine nucleotide-binding protein subunit beta-like protein Receptor of activated protein kinase C homolog
External Links
UniProt	O18640
EMBL	U96491 AE014134 AY071661
RefSeq	NP_001260218.1 NP_001285723.1 NP_477269.1
UniGene	Dm.6830
PDB	4V6W
PDBsum	4V6W
ProteinModelPortal	O18640
SMR	O18640
BioGrid	60209
DIP	DIP-17169N
IntAct	O18640
MINT	MINT-795417
STRING	7227.FBpp0303680
PaxDb	O18640
PRIDE	O18640
EnsemblMetazoa	FBtr0079565 FBtr0331238 FBtr0345448
GeneID	34070
KEGG	dme:Dmel_CG7111
CTD	10399
FlyBase	FBgn0020618
eggNOG	KOG0279 ENOG410XQGZ
GeneTree	ENSGT00890000139419
InParanoid	O18640
KO	K14753
OMA	QYGYPKR
OrthoDB	EOG091G0KZQ
PhylomeDB	O18640
SignaLink	O18640
GenomeRNAi	34070
PRO	PR:O18640
Proteomes	UP000000803
Bgee	FBgn0020618
ExpressionAtlas	O18640
Genevisible	O18640
GO	GO:0005776 GO:0071013 GO:0005737 GO:0005829 GO:0071011 GO:0005840 GO:0009267 GO:0042335 GO:0075522 GO:0007626 GO:0000398 GO:0046716 GO:0001933 GO:0048477 GO:0018991 GO:0044829 GO:0030838 GO:0045725 GO:0016243 GO:0035220
Gene3D	2.130.10.10
InterPro	IPR020472 IPR015943 IPR001680 IPR019775 IPR017986
Pfam	PF00400
PRINTS	PR00320
SMART	SM00320
SUPFAM	SSF50978
PROSITE	PS00678 PS50082 PS50294

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:26021350^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030838	positive regulation of actin filament polymerization	PMID:26021350^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072344	rescue of stalled ribosome	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000458645 UniProtKB:P63244	P	Seeded From UniProt	complete
enables	GO:0043022	ribosome binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000458645 PomBase:SPAC6B12.15 UniProtKB:P63244	F	Seeded From UniProt	complete
part_of	GO:0022627	cytosolic small ribosomal subunit	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000458645 SGD:S000004722	C	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000458645 UniProtKB:P63244	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000458645 TAIR:locus:2008159 TAIR:locus:2194060 UniProtKB:P63244 UniProtKB:Q8IBA0 dictyBase:DDB_G0275045	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000458645 TAIR:locus:2008159 TAIR:locus:2194060 UniProtKB:P63244	C	Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000458645 PomBase:SPAC6B12.15 RGD:69229 UniProtKB:P63244 UniProtKB:Q8IBA0	F	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000458645 UniProtKB:P63244	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:25294944^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0075522	IRES-dependent viral translational initiation	PMID:25416947^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044829	positive regulation by host of viral genome replication	PMID:25416947^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016243	regulation of autophagosome size	PMID:22562043^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:22562043^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	PMID:22562043^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:22562043^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	PMID:21256839^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0260003	P	Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	PMID:21256839^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0034072	P	Seeded From UniProt	complete
part_of	GO:0071011	precatalytic spliceosome	PMID:18981222^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0071013	catalytic step 2 spliceosome	PMID:18981222^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:18981222^[7]	ECO:0000305	curator inference used in manual assertion	GO:0071011,GO:0071013	P	Seeded From UniProt	complete
involved_in	GO:0018991	oviposition	PMID:17584887^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	PMID:17584887^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17584887^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042335	cuticle development	PMID:17584887^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035220	wing disc development	PMID:17584887^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:17584887^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005840	ribosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0689	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Dopie, J et al. (2015) Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators. J. Cell. Sci. 128 2388-400 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page
↑ ^4.0 ^4.1 Majzoub, K et al. (2014) RACK1 controls IRES-mediated translation of viruses. Cell 159 1086-1095 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Erdi, B et al. (2012) Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila. Autophagy 8 1124-35 PubMed GONUTS page
↑ ^6.0 ^6.1 Kucherenko, MM et al. (2011) Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. Dev. Biol. 352 228-42 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Kadrmas, JL et al. (2007) Characterization of RACK1 function in Drosophila development. Dev. Dyn. 236 2207-15 PubMed GONUTS page

[PMID:26021350-1] 1.0 ^1.1 Dopie, J et al. (2015) Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators. J. Cell. Sci. 128 2388-400 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25294944-3] Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page

[PMID:25416947-4] 4.0 ^4.1 Majzoub, K et al. (2014) RACK1 controls IRES-mediated translation of viruses. Cell 159 1086-1095 PubMed GONUTS page

[PMID:22562043-5] 5.0 ^5.1 ^5.2 ^5.3 Erdi, B et al. (2012) Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila. Autophagy 8 1124-35 PubMed GONUTS page

[PMID:21256839-6] 6.0 ^6.1 Kucherenko, MM et al. (2011) Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. Dev. Biol. 352 228-42 PubMed GONUTS page

[PMID:18981222-7] 7.0 ^7.1 ^7.2 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page

[PMID:17584887-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Kadrmas, JL et al. (2007) Characterization of RACK1 function in Drosophila development. Dev. Dyn. 236 2207-15 PubMed GONUTS page

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DROME:GBLP

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