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This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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DROME:FRU

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) fru (synonyms: BTB-VI)
Protein Name(s) Sex determination protein fruitless
External Links
UniProt Q8IN81
EMBL AF039231
U72492
D84437
D84438
AF220176
AF220177
AF220178
AF220179
AF220180
AF220181
AE014297
AE014297
AE014297
AE014297
AE014297
AE014297
AE014297
AE014297
AE014297
AE014297
AE014297
AE014297
AE014297
BT024450
AY152837
AY152838
U14403
RefSeq NP_001163648.1
NP_524397.2
NP_732344.1
NP_732345.1
NP_732346.1
NP_732347.1
NP_732348.1
NP_732349.1
NP_732350.1
NP_996234.1
NP_996235.1
NP_996236.1
NP_996237.1
NP_996238.1
UniGene Dm.4626
ProteinModelPortal Q8IN81
SMR Q8IN81
BioGrid 67237
DIP DIP-17120N
IntAct Q8IN81
MINT MINT-773162
STRING 7227.FBpp0083063
PaxDb Q8IN81
PRIDE Q8IN81
EnsemblMetazoa FBtr0083643
GeneID 42226
KEGG dme:Dmel_CG14307
UCSC CG14307-RA
CTD 42226
FlyBase FBgn0004652
eggNOG NOG146019
GeneTree ENSGT00530000064321
InParanoid Q8IN81
OMA PDNIDGP
OrthoDB EOG7XWPP5
GenomeRNAi 42226
NextBio 827755
PRO PR:Q8IN81
Proteomes UP000000803
Bgee Q8IN81
ExpressionAtlas Q8IN81
GO GO:0005634
GO:0003677
GO:0046872
GO:0003700
GO:0002118
GO:0016199
GO:0007417
GO:0007620
GO:0048813
GO:0008049
GO:0016543
GO:0045433
GO:0016545
GO:0060179
GO:0046661
GO:0007618
GO:0007617
GO:0048047
GO:0007275
GO:0007517
GO:0044719
GO:0007530
GO:0006351
Gene3D 3.30.160.60
InterPro IPR000210
IPR011333
IPR013069
IPR007087
IPR015880
IPR013087
Pfam PF00651
SMART SM00225
SM00355
SUPFAM SSF54695
PROSITE PS50097
PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0048065

male courtship behavior, veined wing extension

PMID:15959468[1]

IMP: Inferred from Mutant Phenotype

P

See Figure 4d.

complete
CACAO 5632

GO:0016544

male courtship behavior, tapping to detect pheromone

PMID:15959468[1]

IMP: Inferred from Mutant Phenotype

P

See Figure 4d.

complete
CACAO 5633

GO:0044428

nuclear part

PMID:15959468[1]

IDA: Inferred from Direct Assay

C

See Figure 2.

complete
CACAO 5638

GO:0048047

mating behavior, sex discrimination

PMID:15959468[1]

IMP: Inferred from Mutant Phenotype

P

See Figure 4a for male-male habituation.

complete
CACAO 5639

GO:0021954

central nervous system neuron development

PMID:16281036[2]

IDA: Inferred from Direct Assay

P

See Figure 2.

complete
CACAO 5640

GO:0046544

development of secondary male sexual characteristics

PMID:15959468[1]

IDA: Inferred from Direct Assay

P

See Figure 3 for different organs Fru affects.

complete
CACAO 5641

GO:0002118

aggressive behavior

PMID:18042702[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0021954

central nervous system neuron development

PMID:16281036[2]

IDA: Inferred from Direct Assay

P

Figure 3

complete
CACAO 6162

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013087

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:10648226[4]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:11092827[5]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:7938017[6]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:22682252[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VDK5

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:22682252[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VDK5

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

PMID:8978612[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007417

central nervous system development

PMID:12486700[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007417

central nervous system development

PMID:12524343[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007517

muscle organ development

PMID:10934470[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007517

muscle organ development

PMID:8978612[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007530

sex determination

PMID:10934470[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007530

sex determination

PMID:11092827[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007530

sex determination

PMID:11715043[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007530

sex determination

PMID:8978612[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007617

mating behavior

PMID:11291102[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007618

mating

PMID:8244010[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007620

copulation

PMID:12000098[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007620

copulation

PMID:12486700[9]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:10858821[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:10934470[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:11092827[5]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:11300999[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:11514448[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:11715043[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:12350340[19]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:12486700[9]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:15959468[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:16179386[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:18167550[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:1821857[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:23144871[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:24440396[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:8244010[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0016199

axon midline choice point recognition

PMID:20040498[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016543

male courtship behavior, orientation prior to leg tapping and wing vibration

PMID:12000098[15]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0016544

male courtship behavior, tapping to detect pheromone

PMID:15959468[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016545

male courtship behavior, veined wing vibration

PMID:2508613[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0021954

central nervous system neuron development

PMID:16281036[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0044719

regulation of imaginal disc-derived wing size

PMID:23232763[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045433

male courtship behavior, veined wing generated song production

PMID:12000098[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045433

male courtship behavior, veined wing generated song production

PMID:24440391[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045433

male courtship behavior, veined wing generated song production

PMID:8978612[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046661

male sex differentiation

PMID:12486700[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007087

F

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0048047

mating behavior, sex discrimination

PMID:12486700[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048047

mating behavior, sex discrimination

PMID:15959468[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048047

mating behavior, sex discrimination

PMID:20967276[29]

IGI: Inferred from Genetic Interaction

FB:FBgn0010329

P

Seeded From UniProt

complete

GO:0048047

mating behavior, sex discrimination

PMID:20967276[29]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048065

male courtship behavior, veined wing extension

PMID:15959468[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048813

dendrite morphogenesis

PMID:21471381[30]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060179

male mating behavior

PMID:24440391[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Manoli, DS et al. (2005) Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour. Nature 436 395-400 PubMed GONUTS page
  2. 2.0 2.1 2.2 Kimura, K et al. (2005) Fruitless specifies sexually dimorphic neural circuitry in the Drosophila brain. Nature 438 229-33 PubMed GONUTS page
  3. Chan, YB & Kravitz, EA (2007) Specific subgroups of FruM neurons control sexually dimorphic patterns of aggression in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 104 19577-82 PubMed GONUTS page
  4. Schütt, C & Nöthiger, R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127 667-77 PubMed GONUTS page
  5. 5.0 5.1 5.2 Greenspan, RJ & Ferveur, JF (2000) Courtship in Drosophila. Annu. Rev. Genet. 34 205-232 PubMed GONUTS page
  6. Zollman, S et al. (1994) The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 91 10717-21 PubMed GONUTS page
  7. 7.0 7.1 Ito, H et al. (2012) Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism. Cell 149 1327-38 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Ryner, LC et al. (1996) Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell 87 1079-89 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 Emmons, SW & Lipton, J (2003) Genetic basis of male sexual behavior. J. Neurobiol. 54 93-110 PubMed GONUTS page
  10. Song, HJ et al. (2002) The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. Genetics 162 1703-24 PubMed GONUTS page
  11. 11.0 11.1 11.2 Usui-Aoki, K et al. (2000) Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression. Nat. Cell Biol. 2 500-6 PubMed GONUTS page
  12. 12.0 12.1 Sokolowski, MB (2001) Drosophila: genetics meets behaviour. Nat. Rev. Genet. 2 879-90 PubMed GONUTS page
  13. Lee, G et al. (2001) New reproductive anomalies in fruitless-mutant Drosophila males: extreme lengthening of mating durations and infertility correlated with defective serotonergic innervation of reproductive organs. J. Neurobiol. 47 121-49 PubMed GONUTS page
  14. 14.0 14.1 Castrillon, DH et al. (1993) Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics 135 489-505 PubMed GONUTS page
  15. 15.0 15.1 15.2 Billeter, JC et al. (2002) Genes mediating sex-specific behaviors in Drosophila. Adv. Genet. 47 87-116 PubMed GONUTS page
  16. Nilsson, EE et al. (2000) Fruitless is in the regulatory pathway by which ectopic mini-white and transformer induce bisexual courtship in Drosophila. J. Neurogenet. 13 213-32 PubMed GONUTS page
  17. Baker, BS et al. (2001) Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell 105 13-24 PubMed GONUTS page
  18. Anand, A et al. (2001) Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless. Genetics 158 1569-95 PubMed GONUTS page
  19. Christiansen, AE et al. (2002) Sex comes in from the cold: the integration of sex and pattern. Trends Genet. 18 510-6 PubMed GONUTS page
  20. Villella, A et al. (2005) Functional analysis of fruitless gene expression by transgenic manipulations of Drosophila courtship. Proc. Natl. Acad. Sci. U.S.A. 102 16550-7 PubMed GONUTS page
  21. Lee, HG et al. (2008) Recurring ethanol exposure induces disinhibited courtship in Drosophila. PLoS ONE 3 e1391 PubMed GONUTS page
  22. Gailey, DA et al. (1991) Elements of the fruitless locus regulate development of the muscle of Lawrence, a male-specific structure in the abdomen of Drosophila melanogaster adults. Development 113 879-90 PubMed GONUTS page
  23. Ramdya, P et al. (2012) Fluorescence behavioral imaging (FBI) tracks identity in heterogeneous groups of Drosophila. PLoS ONE 7 e48381 PubMed GONUTS page
  24. Neville, MC et al. (2014) Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system. Curr. Biol. 24 229-41 PubMed GONUTS page
  25. Mellert, DJ et al. (2010) Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors. Development 137 323-32 PubMed GONUTS page
  26. Wheeler, DA et al. (1989) Spectral analysis of courtship songs in behavioral mutants of Drosophila melanogaster. Behav. Genet. 19 503-28 PubMed GONUTS page
  27. Djiane, A et al. (2013) Dissecting the mechanisms of Notch induced hyperplasia. EMBO J. 32 60-71 PubMed GONUTS page
  28. 28.0 28.1 von Philipsborn, AC et al. (2014) Cellular and behavioral functions of fruitless isoforms in Drosophila courtship. Curr. Biol. 24 242-51 PubMed GONUTS page
  29. 29.0 29.1 Certel, SJ et al. (2010) Octopamine neuromodulatory effects on a social behavior decision-making network in Drosophila males. PLoS ONE 5 e13248 PubMed GONUTS page
  30. Goto, J et al. (2011) Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. J. Neurosci. 31 5454-9 PubMed GONUTS page