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PMID:24440396

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Citation

Neville, MC, Nojima, T, Ashley, E, Parker, DJ, Walker, J, Southall, T, Van de Sande, B, Marques, AC, Fischer, B, Brand, AH, Russell, S, Ritchie, MG, Aerts, S and Goodwin, SF (2014) Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system. Curr. Biol. 24:229-41

Abstract

In Drosophila, male courtship behavior is regulated in large part by the gene fruitless (fru). fru encodes a set of putative transcription factors that promote male sexual behavior by controlling the development of sexually dimorphic neuronal circuitry. Little is known about how Fru proteins function at the level of transcriptional regulation or the role that isoform diversity plays in the formation of a male-specific nervous system.

Links

PubMed PMC3969260 Online version:10.1016/j.cub.2013.11.035

Keywords

Animals; Base Sequence; Central Nervous System/metabolism; Drosophila Proteins/genetics; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; Gene Expression Regulation, Developmental/genetics; Gene Knockout Techniques; Male; Molecular Sequence Data; Nerve Tissue Proteins/genetics; Neurogenesis/genetics; Protein Isoforms/genetics; Sex Characteristics; Sexual Behavior, Animal/physiology; Transcription Factors/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:FRU

involved_in

GO:0008049: male courtship behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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