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DROME:DMYC
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | Drs (synonyms: CRP) | |
| Protein Name(s) | Drosomycin
Cysteine-rich peptide | |
| External Links | ||
| UniProt | P41964 | |
| EMBL | X75595 AJ885056 AJ885057 AJ885058 AJ885059 AJ885060 AJ885061 AJ885062 AJ885063 AJ885064 AJ885065 AJ885066 AJ885067 AJ885068 AJ885069 AJ885070 AJ885071 AJ885072 AJ885073 AJ885074 AJ885075 AJ885086 AE014296 AY119009 | |
| PIR | A55824 | |
| RefSeq | NP_523901.1 | |
| UniGene | Dm.14479 | |
| PDB | 1MYN | |
| PDBsum | 1MYN | |
| ProteinModelPortal | P41964 | |
| SMR | P41964 | |
| DIP | DIP-18879N | |
| MINT | MINT-291861 | |
| PaxDb | P41964 | |
| PRIDE | P41964 | |
| EnsemblMetazoa | FBtr0073073 | |
| GeneID | 38419 | |
| KEGG | dme:Dmel_CG10810 | |
| CTD | 38419 | |
| FlyBase | FBgn0010381 | |
| eggNOG | NOG329278 | |
| GeneTree | ENSGT00540000073894 | |
| InParanoid | P41964 | |
| OMA | FWSGACW | |
| OrthoDB | EOG75F4GX | |
| PhylomeDB | P41964 | |
| EvolutionaryTrace | P41964 | |
| GenomeRNAi | 38419 | |
| NextBio | 808566 | |
| Proteomes | UP000000803 | |
| Bgee | P41964 | |
| GO | GO:0005576 GO:0019731 GO:0019732 GO:0051715 GO:0006952 GO:0050832 GO:0050829 GO:0042832 GO:0045087 GO:0009617 | |
| Gene3D | 3.30.30.10 | |
| InterPro | IPR008176 IPR003614 | |
| Pfam | PF00304 | |
| SMART | SM00505 | |
| SUPFAM | SSF57095 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019732 |
antifungal humoral response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019732 |
antifungal humoral response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019732 |
antifungal humoral response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019732 |
antifungal humoral response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009617 |
response to bacterium |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042832 |
defense response to protozoan |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009617 |
response to bacterium |
ECO:0007007 |
high throughput expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006952 |
defense response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019732 |
antifungal humoral response |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006952 |
defense response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019732 |
antifungal humoral response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050829 |
defense response to Gram-negative bacterium |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019731 |
antibacterial humoral response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Simon, A et al. (2008) Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity. Antimicrob. Agents Chemother. 52 1407-12 PubMed GONUTS page
- ↑ Wagner, C et al. (2009) Infection induces a survival program and local remodeling in the airway epithelium of the fly. FASEB J. 23 2045-54 PubMed GONUTS page
- ↑ Zhang, Z & Zhu, S (2010) Functional role of charged residues in drosomycin, a Drosophila antifungal peptide. Dev. Comp. Immunol. 34 953-8 PubMed GONUTS page
- ↑ 4.0 4.1 Tian, C et al. (2008) Gene expression, antiparasitic activity, and functional evolution of the drosomycin family. Mol. Immunol. 45 3909-16 PubMed GONUTS page
- ↑ Yang, WY et al. (2006) Functional divergence of six isoforms of antifungal peptide Drosomycin in Drosophila melanogaster. Gene 379 26-32 PubMed GONUTS page
- ↑ Levy, F et al. () Peptidomic and proteomic analyses of the systemic immune response of Drosophila. Biochimie 86 607-16 PubMed GONUTS page
- ↑ Kimbrell, DA & Beutler, B (2001) The evolution and genetics of innate immunity. Nat. Rev. Genet. 2 256-67 PubMed GONUTS page
- ↑ 8.0 8.1 Uttenweiler-Joseph, S et al. (1998) Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study. Proc. Natl. Acad. Sci. U.S.A. 95 11342-7 PubMed GONUTS page
- ↑ Lemaitre, B et al. (1997) Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc. Natl. Acad. Sci. U.S.A. 94 14614-9 PubMed GONUTS page
- ↑ Levashina, EA et al. (1995) Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties. Eur. J. Biochem. 233 694-700 PubMed GONUTS page
- ↑ 11.0 11.1 Fehlbaum, P et al. (1994) Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides. J. Biol. Chem. 269 33159-63 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Brennan, CA & Anderson, KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu. Rev. Immunol. 22 457-83 PubMed GONUTS page
- ↑ Silverman, N (2003) Flies kNOw how to signal. Dev. Cell 4 5-6 PubMed GONUTS page
- ↑ Chapman, T (2001) Seminal fluid-mediated fitness traits in Drosophila. Heredity (Edinb) 87 511-21 PubMed GONUTS page
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