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DROME:DMYC

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Drs (synonyms: CRP)
Protein Name(s) Drosomycin

Cysteine-rich peptide

External Links
UniProt P41964
EMBL X75595
AJ885056
AJ885057
AJ885058
AJ885059
AJ885060
AJ885061
AJ885062
AJ885063
AJ885064
AJ885065
AJ885066
AJ885067
AJ885068
AJ885069
AJ885070
AJ885071
AJ885072
AJ885073
AJ885074
AJ885075
AJ885086
AE014296
AY119009
PIR A55824
RefSeq NP_523901.1
UniGene Dm.14479
PDB 1MYN
PDBsum 1MYN
ProteinModelPortal P41964
SMR P41964
DIP DIP-18879N
MINT MINT-291861
PaxDb P41964
PRIDE P41964
EnsemblMetazoa FBtr0073073
GeneID 38419
KEGG dme:Dmel_CG10810
CTD 38419
FlyBase FBgn0010381
eggNOG NOG329278
GeneTree ENSGT00540000073894
InParanoid P41964
OMA FWSGACW
OrthoDB EOG75F4GX
PhylomeDB P41964
EvolutionaryTrace P41964
GenomeRNAi 38419
NextBio 808566
Proteomes UP000000803
Bgee P41964
GO GO:0005576
GO:0019731
GO:0019732
GO:0051715
GO:0006952
GO:0050832
GO:0050829
GO:0042832
GO:0045087
GO:0009617
Gene3D 3.30.30.10
InterPro IPR008176
IPR003614
Pfam PF00304
SMART SM00505
SUPFAM SSF57095

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:18212107[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019732

antifungal humoral response

PMID:18212107[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019732

antifungal humoral response

PMID:18212107[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019732

antifungal humoral response

PMID:18212107[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019732

antifungal humoral response

PMID:18212107[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009617

response to bacterium

PMID:19237508[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

PMID:20420852[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042832

defense response to protozoan

PMID:18657321[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

PMID:18657321[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

PMID:16824706[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009617

response to bacterium

PMID:15556270[6]

ECO:0007007

high throughput expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003674

molecular_function

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

PMID:11283698[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:9736738[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

PMID:9736738[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019732

antifungal humoral response

PMID:9405661[9]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

PMID:7588819[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

PMID:7806546[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:7806546[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003614

P

Seeded From UniProt

complete

involved_in

GO:0019732

antifungal humoral response

PMID:15032585[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:15032585[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019731

antibacterial humoral response

PMID:15032585[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

PMID:12530956[13]
PMID:11869341[14]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0295

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0295

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Simon, A et al. (2008) Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity. Antimicrob. Agents Chemother. 52 1407-12 PubMed GONUTS page
  2. Wagner, C et al. (2009) Infection induces a survival program and local remodeling in the airway epithelium of the fly. FASEB J. 23 2045-54 PubMed GONUTS page
  3. Zhang, Z & Zhu, S (2010) Functional role of charged residues in drosomycin, a Drosophila antifungal peptide. Dev. Comp. Immunol. 34 953-8 PubMed GONUTS page
  4. 4.0 4.1 Tian, C et al. (2008) Gene expression, antiparasitic activity, and functional evolution of the drosomycin family. Mol. Immunol. 45 3909-16 PubMed GONUTS page
  5. Yang, WY et al. (2006) Functional divergence of six isoforms of antifungal peptide Drosomycin in Drosophila melanogaster. Gene 379 26-32 PubMed GONUTS page
  6. Levy, F et al. () Peptidomic and proteomic analyses of the systemic immune response of Drosophila. Biochimie 86 607-16 PubMed GONUTS page
  7. Kimbrell, DA & Beutler, B (2001) The evolution and genetics of innate immunity. Nat. Rev. Genet. 2 256-67 PubMed GONUTS page
  8. 8.0 8.1 Uttenweiler-Joseph, S et al. (1998) Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study. Proc. Natl. Acad. Sci. U.S.A. 95 11342-7 PubMed GONUTS page
  9. Lemaitre, B et al. (1997) Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc. Natl. Acad. Sci. U.S.A. 94 14614-9 PubMed GONUTS page
  10. Levashina, EA et al. (1995) Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties. Eur. J. Biochem. 233 694-700 PubMed GONUTS page
  11. 11.0 11.1 Fehlbaum, P et al. (1994) Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides. J. Biol. Chem. 269 33159-63 PubMed GONUTS page
  12. 12.0 12.1 12.2 Brennan, CA & Anderson, KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu. Rev. Immunol. 22 457-83 PubMed GONUTS page
  13. Silverman, N (2003) Flies kNOw how to signal. Dev. Cell 4 5-6 PubMed GONUTS page
  14. Chapman, T (2001) Seminal fluid-mediated fitness traits in Drosophila. Heredity (Edinb) 87 511-21 PubMed GONUTS page