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DROME:CDK1

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) cdc2 (synonyms: cdk1)
Protein Name(s) Cyclin-dependent kinase 1

CDK1 Cell division control protein 2 homolog Cell division protein kinase 1 p34 protein kinase

External Links
UniProt P23572
EMBL X57485
X57496
S66801
S66804
S66805
S66807
S66810
AM294319
AM294320
AM294321
AM294322
AM294323
AM294324
AM294325
AM294326
AM294327
AM294328
AM294329
AE014134
AY061450
PIR S12009
RefSeq NP_476797.1
UniGene Dm.3187
ProteinModelPortal P23572
SMR P23572
BioGrid 60495
DIP DIP-649N
IntAct P23572
MINT MINT-292976
STRING 7227.FBpp0079641
PaxDb P23572
PRIDE P23572
EnsemblMetazoa FBtr0080051
GeneID 34411
KEGG dme:Dmel_CG5363
CTD 34411
FlyBase FBgn0004106
eggNOG COG0515
GeneTree ENSGT00790000122973
InParanoid P23572
KO K02087
OMA QNYSRIE
OrthoDB EOG7966H8
PhylomeDB P23572
Reactome REACT_276179
REACT_282432
REACT_283248
REACT_284729
REACT_286636
REACT_287862
REACT_299649
REACT_301564
REACT_317616
REACT_318147
REACT_318689
REACT_319950
REACT_321324
REACT_324794
REACT_331011
REACT_335593
REACT_340065
REACT_345084
REACT_353740
REACT_354208
SignaLink P23572
GenomeRNAi 34411
NextBio 788369
PRO PR:P23572
Proteomes UP000000803
Bgee P23572
ExpressionAtlas P23572
Genevisible P23572
GO GO:0005875
GO:0005634
GO:0005524
GO:0004693
GO:0004672
GO:0004674
GO:0008353
GO:0055059
GO:0006974
GO:0000082
GO:0000086
GO:0048142
GO:0007140
GO:0007141
GO:0008315
GO:0000278
GO:0007095
GO:0044818
GO:0007067
GO:0022008
GO:0006468
GO:0032880
GO:0007283
GO:0007284
InterPro IPR011009
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
SMART SM00220
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000082

G1/S transition of mitotic cell cycle

PMID:2120045[1]

IGI: Inferred from Genetic Interaction

SGD:S000000364

P

Seeded From UniProt

GO:0000086

G2/M transition of mitotic cell cycle

PMID:2120045[1]

IGI: Inferred from Genetic Interaction

SGD:S000000364

P

Seeded From UniProt

GO:0000086

G2/M transition of mitotic cell cycle

PMID:8223248[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

GO:0000278

mitotic cell cycle

PMID:14527345[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR008271

F

Seeded From UniProt

GO:0004672

protein kinase activity

PMID:24214341[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

GO:0004674

protein serine/threonine kinase activity

PMID:10908587[5]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.11.22

F

Seeded From UniProt

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

PMID:2120045[1]

IGI: Inferred from Genetic Interaction

SGD:S000000364

F

Seeded From UniProt

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

PMID:2120045[1]

ISS: Inferred from Sequence or Structural Similarity

SGD:S000000364

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15575970[6]

IPI: Inferred from Physical Interaction

UniProtKB:P25008

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15575970[6]

IPI: Inferred from Physical Interaction

UniProtKB:P54733

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15575970[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q03019

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15575970[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q961D1

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15575970[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VHN1

F

Seeded From UniProt

GO:0005515

protein binding

PMID:16603075[7]

IPI: Inferred from Physical Interaction

UniProtKB:P25008

F

Seeded From UniProt

GO:0005515

protein binding

PMID:16603075[7]

IPI: Inferred from Physical Interaction

UniProtKB:P54733

F

Seeded From UniProt

GO:0005515

protein binding

PMID:16603075[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q03019

F

Seeded From UniProt

GO:0005515

protein binding

PMID:16603075[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q961D1

F

Seeded From UniProt

GO:0005515

protein binding

PMID:16603075[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VHN1

F

Seeded From UniProt

GO:0005515

protein binding

PMID:17431409[8]

IPI: Inferred from Physical Interaction

UniProtKB:P54733

F

Seeded From UniProt

GO:0005515

protein binding

PMID:7809159[9]

IPI: Inferred from Physical Interaction

UniProtKB:P54733

F

Seeded From UniProt

GO:0005515

protein binding

PMID:9851980[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q9I7I0

F

Seeded From UniProt

GO:0005515

protein binding

PMID:9851980[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q9I7I0

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR017441

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005875

microtubule associated complex

PMID:18433294[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR008271

P

Seeded From UniProt

GO:0006468

protein phosphorylation

PMID:10908587[5]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0006468

protein phosphorylation

PMID:8675008[12]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0006974

cellular response to DNA damage stimulus

PMID:19543366[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

GO:0007067

mitotic nuclear division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0498

P

Seeded From UniProt

GO:0007095

mitotic G2 DNA damage checkpoint

PMID:24214341[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007140

male meiosis

PMID:16107480[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007141

male meiosis I

PMID:9813190[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007283

spermatogenesis

PMID:9813190[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007284

spermatogonial cell division

PMID:16107480[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0008315

meiotic G2/MI transition

PMID:9813190[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0008353

RNA polymerase II carboxy-terminal domain kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.11.23

F

Seeded From UniProt

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

GO:0022008

neurogenesis

PMID:21549331[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0032880

regulation of protein localization

PMID:12105185[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0044818

mitotic G2/M transition checkpoint

PMID:24214341[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048142

germarium-derived cystoblast division

PMID:16107480[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0051301

cell division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

Seeded From UniProt

GO:0055059

asymmetric neuroblast division

PMID:11234018[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0055059

asymmetric neuroblast division

PMID:11697883[19]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0045169

fusome

PMID:27170181[20]

IDA: Inferred from Direct Assay

C

Drosophila melanogaster CDK1 Figure 2. Cdk1(WT)-GFP localizes to fusomes

complete
CACAO 12339

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Lehner, CF & O'Farrell, PH (1990) Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. EMBO J. 9 3573-81 PubMed GONUTS page
  2. Stern, B et al. (1993) Genetic analysis of the Drosophila cdc2 homolog. Development 117 219-32 PubMed GONUTS page
  3. Kiger, AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J. Biol. 2 27 PubMed GONUTS page
  4. 4.0 4.1 4.2 Ayeni, JO et al. (2014) Dual phosphorylation of cdk1 coordinates cell proliferation with key developmental processes in Drosophila. Genetics 196 197-210 PubMed GONUTS page
  5. 5.0 5.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Stanyon, CA et al. (2004) A Drosophila protein-interaction map centered on cell-cycle regulators. Genome Biol. 5 R96 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 Pacifico, S et al. (2006) A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila. BMC Bioinformatics 7 195 PubMed GONUTS page
  8. Gawliński, P et al. (2007) The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of cyclins. EMBO Rep. 8 490-6 PubMed GONUTS page
  9. Finley, RL Jr & Brent, R (1994) Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators. Proc. Natl. Acad. Sci. U.S.A. 91 12980-4 PubMed GONUTS page
  10. 10.0 10.1 Jacobs, HW et al. (1998) Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B. Genes Dev. 12 3741-51 PubMed GONUTS page
  11. Hughes, JR et al. (2008) A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol. 6 e98 PubMed GONUTS page
  12. Du, W et al. (1996) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10 1206-18 PubMed GONUTS page
  13. Ravi, D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet. 5 e1000527 PubMed GONUTS page
  14. 14.0 14.1 14.2 Jin, Z et al. (2005) Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis. Development 132 4075-85 PubMed GONUTS page
  15. 15.0 15.1 15.2 Fuller, MT (1998) Genetic control of cell proliferation and differentiation in Drosophila spermatogenesis. Semin. Cell Dev. Biol. 9 433-44 PubMed GONUTS page
  16. Neumüller, RA et al. (2011) Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Cell Stem Cell 8 580-93 PubMed GONUTS page
  17. Royou, A et al. (2002) Cortical recruitment of nonmuscle myosin II in early syncytial Drosophila embryos: its role in nuclear axial expansion and its regulation by Cdc2 activity. J. Cell Biol. 158 127-37 PubMed GONUTS page
  18. Tio, M et al. (2001) cdc2 links the Drosophila cell cycle and asymmetric division machineries. Nature 409 1063-7 PubMed GONUTS page
  19. Schaefer, M & Knoblich, JA (2001) Protein localization during asymmetric cell division. Exp. Cell Res. 271 66-74 PubMed GONUTS page
  20. Varadarajan, R et al. (2016) Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes. Mol. Biol. Cell 27 2051-63 PubMed GONUTS page