DROME:CDK1

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	cdc2 (synonyms: cdk1)
Protein Name(s)	Cyclin-dependent kinase 1 CDK1 Cell division control protein 2 homolog Cell division protein kinase 1 p34 protein kinase
External Links
UniProt	P23572
EMBL	X57485 X57496 S66801 S66804 S66805 S66807 S66810 AM294319 AM294320 AM294321 AM294322 AM294323 AM294324 AM294325 AM294326 AM294327 AM294328 AM294329 AE014134 AY061450
PIR	S12009
RefSeq	NP_476797.1
UniGene	Dm.3187
ProteinModelPortal	P23572
SMR	P23572
BioGrid	60495
DIP	DIP-649N
IntAct	P23572
MINT	MINT-292976
STRING	7227.FBpp0079641
PaxDb	P23572
PRIDE	P23572
EnsemblMetazoa	FBtr0080051
GeneID	34411
KEGG	dme:Dmel_CG5363
CTD	34411
FlyBase	FBgn0004106
eggNOG	COG0515
GeneTree	ENSGT00790000122973
InParanoid	P23572
KO	K02087
OMA	QNYSRIE
OrthoDB	EOG7966H8
PhylomeDB	P23572
Reactome	REACT_276179 REACT_282432 REACT_283248 REACT_284729 REACT_286636 REACT_287862 REACT_299649 REACT_301564 REACT_317616 REACT_318147 REACT_318689 REACT_319950 REACT_321324 REACT_324794 REACT_331011 REACT_335593 REACT_340065 REACT_345084 REACT_353740 REACT_354208
SignaLink	P23572
GenomeRNAi	34411
NextBio	788369
PRO	PR:P23572
Proteomes	UP000000803
Bgee	P23572
ExpressionAtlas	P23572
Genevisible	P23572
GO	GO:0005875 GO:0005634 GO:0005524 GO:0004693 GO:0004672 GO:0004674 GO:0008353 GO:0055059 GO:0006974 GO:0000082 GO:0000086 GO:0048142 GO:0007140 GO:0007141 GO:0008315 GO:0000278 GO:0007095 GO:0044818 GO:0007067 GO:0022008 GO:0006468 GO:0032880 GO:0007283 GO:0007284
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1901987	regulation of cell cycle phase transition	PMID:29746464^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001700	embryonic development via the syncytial blastoderm	PMID:29746464^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030174	regulation of DNA-dependent DNA replication initiation	PMID:29746464^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q9XZ34)	Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002373207 UniProtKB:P06493	C		Seeded From UniProt	complete
involved_in	GO:0044772	mitotic cell cycle phase transition	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88351 PANTHER:PTN002373207	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013435 FB:FBgn0013762 FB:FBgn0015618 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 RGD:621124 RGD:70514 SGD:S000001622 SGD:S000001865 SGD:S000005488 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2119961 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q9UQ88 WB:WBGene00000405 WB:WBGene00000407 WB:WBGene00019362 ZFIN:ZDB-GENE-040808-34 dictyBase:DDB_G0267442 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002373207 RGD:2319 WB:WBGene00000405	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015618 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:102956 MGI:MGI:104772 MGI:MGI:1328368 MGI:MGI:88353 MGI:MGI:88357 MGI:MGI:894318 PANTHER:PTN000623091 PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC32H8.10 RGD:1305435 RGD:1359638 RGD:2319 RGD:619874 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000002266 SGD:S000005952 TAIR:locus:2008595 TAIR:locus:2027819 TAIR:locus:2033349 TAIR:locus:2080290 TAIR:locus:2084086 TAIR:locus:2099478 TAIR:locus:2119961 TAIR:locus:2158554 TAIR:locus:2194045 UniProtKB:O76039 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P49336 UniProtKB:P50613 UniProtKB:P61075 UniProtKB:P79432 UniProtKB:Q00534 UniProtKB:Q00535 UniProtKB:Q00646 UniProtKB:Q5B3E4 UniProtKB:Q8IDW1 UniProtKB:Q8IIL5 UniProtKB:Q8IJQ1 UniProtKB:Q8RWN3 UniProtKB:Q8W4P1 UniProtKB:Q92772 UniProtKB:Q96VK3 UniProtKB:Q9NYV4 UniProtKB:Q9UQ88 WB:WBGene00000405 dictyBase:DDB_G0267442 dictyBase:DDB_G0288677	C		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013762 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 PomBase:SPAC23H4.17c PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC19F8.07 PomBase:SPBC32H8.10 RGD:2319 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2011761 UniProtKB:A0A1D8PDA6 UniProtKB:C9K505 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:P61075 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q8IJQ1 WB:WBGene00000405 ZFIN:ZDB-GENE-010131-2 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	F		Seeded From UniProt	complete
involved_in	GO:0030707	ovarian follicle cell development	PMID:26205122^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044818	mitotic G2/M transition checkpoint	PMID:24214341^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007095	mitotic G2 DNA damage checkpoint	PMID:24214341^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:24214341^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007140	male meiotic nuclear division	PMID:16107480^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0045169	fusome	PMID:27170181^[6]	ECO:0000314			C		Drosophila melanogaster CDK1 Figure 2. Cdk1(WT)-GFP localizes to fusomes	complete CACAO 12339
involved_in	GO:0048142	germarium-derived cystoblast division	PMID:16107480^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007284	spermatogonial cell division	PMID:16107480^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:12105185^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055059	asymmetric neuroblast division	PMID:11234018^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:8675008^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	PMID:8223248^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:2120045^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	SGD:S000000364	F		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:2120045^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000364	F		Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	PMID:2120045^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000364	P		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:2120045^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000364	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:28555567^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:28555567^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(FB:FBgn0001120)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.22	F		Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.23	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Seller, CA & O'Farrell, PH (2018) Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition. PLoS Biol. 16 e2005687 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Jia, D et al. (2015) A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches. Sci Rep 5 12328 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Ayeni, JO et al. (2014) Dual phosphorylation of cdk1 coordinates cell proliferation with key developmental processes in Drosophila. Genetics 196 197-210 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Jin, Z et al. (2005) Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis. Development 132 4075-85 PubMed GONUTS page
↑ Varadarajan, R et al. (2016) Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes. Mol. Biol. Cell 27 2051-63 PubMed GONUTS page
↑ Royou, A et al. (2002) Cortical recruitment of nonmuscle myosin II in early syncytial Drosophila embryos: its role in nuclear axial expansion and its regulation by Cdc2 activity. J. Cell Biol. 158 127-37 PubMed GONUTS page
↑ Tio, M et al. (2001) cdc2 links the Drosophila cell cycle and asymmetric division machineries. Nature 409 1063-7 PubMed GONUTS page
↑ Du, W et al. (1996) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10 1206-18 PubMed GONUTS page
↑ Stern, B et al. (1993) Genetic analysis of the Drosophila cdc2 homolog. Development 117 219-32 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Lehner, CF & O'Farrell, PH (1990) Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. EMBO J. 9 3573-81 PubMed GONUTS page
↑ ^12.0 ^12.1 Hara, M et al. (2017) Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation. Elife 6 PubMed GONUTS page

[PMID:29746464-1] 1.0 ^1.1 ^1.2 Seller, CA & O'Farrell, PH (2018) Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition. PLoS Biol. 16 e2005687 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26205122-3] Jia, D et al. (2015) A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches. Sci Rep 5 12328 PubMed GONUTS page

[PMID:24214341-4] 4.0 ^4.1 ^4.2 Ayeni, JO et al. (2014) Dual phosphorylation of cdk1 coordinates cell proliferation with key developmental processes in Drosophila. Genetics 196 197-210 PubMed GONUTS page

[PMID:16107480-5] 5.0 ^5.1 ^5.2 Jin, Z et al. (2005) Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis. Development 132 4075-85 PubMed GONUTS page

[PMID:27170181-6] Varadarajan, R et al. (2016) Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes. Mol. Biol. Cell 27 2051-63 PubMed GONUTS page

[PMID:12105185-7] Royou, A et al. (2002) Cortical recruitment of nonmuscle myosin II in early syncytial Drosophila embryos: its role in nuclear axial expansion and its regulation by Cdc2 activity. J. Cell Biol. 158 127-37 PubMed GONUTS page

[PMID:11234018-8] Tio, M et al. (2001) cdc2 links the Drosophila cell cycle and asymmetric division machineries. Nature 409 1063-7 PubMed GONUTS page

[PMID:8675008-9] Du, W et al. (1996) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10 1206-18 PubMed GONUTS page

[PMID:8223248-10] Stern, B et al. (1993) Genetic analysis of the Drosophila cdc2 homolog. Development 117 219-32 PubMed GONUTS page

[PMID:2120045-11] 11.0 ^11.1 ^11.2 ^11.3 Lehner, CF & O'Farrell, PH (1990) Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. EMBO J. 9 3573-81 PubMed GONUTS page

[PMID:28555567-12] 12.0 ^12.1 Hara, M et al. (2017) Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation. Elife 6 PubMed GONUTS page

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DROME:CDK1

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