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PMID:11234018
| Citation |
Tio, M, Udolph, G, Yang, X and Chia, W (2001) cdc2 links the Drosophila cell cycle and asymmetric division machineries. Nature 409:1063-7 |
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| Abstract |
Asymmetric cell divisions can be mediated by the preferential segregation of cell-fate determinants into one of two sibling daughters. In Drosophila neural progenitors, Inscuteable, Partner of Inscuteable and Bazooka localize as an apical cortical complex at interphase, which directs the apical-basal orientation of the mitotic spindle as well as the basal/cortical localization of the cell-fate determinants Numb and/or Prospero during mitosis. Although localization of these proteins shows dependence on the cell cycle, the involvement of cell-cycle components in asymmetric divisions has not been demonstrated. Here we show that neural progenitor asymmetric divisions require the cell-cycle regulator cdc2. By attenuating Drosophila cdc2 function without blocking mitosis, normally asymmetric progenitor divisions become defective, failing to correctly localize asymmetric components during mitosis and/or to resolve distinct sibling fates. cdc2 is not necessary for initiating apical complex formation during interphase; however, maintaining the asymmetric localization of the apical components during mitosis requires Cdc2/B-type cyclin complexes. Our findings link cdc2 with asymmetric divisions, and explain why the asymmetric localization of molecules like Inscuteable show cell-cycle dependence. |
| Links |
PubMed Online version:10.1038/35059124 |
| Keywords |
Animals; CDC2 Protein Kinase/genetics; CDC2 Protein Kinase/physiology; Carrier Proteins/physiology; Cell Cycle; Cell Cycle Proteins/physiology; Cell Division; Central Nervous System/cytology; Cyclins/metabolism; Cytoskeletal Proteins/physiology; Drosophila; Drosophila Proteins; Genotype; Mutation; Nerve Tissue Proteins/physiology; Neuropeptides; Nuclear Proteins/physiology; Phenotype; Phosphorylation; Transcription Factors |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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