DROME:BCD

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	bcd
Protein Name(s)	Homeotic protein bicoid PRD-4
External Links
UniProt	P09081
EMBL	X07870 X14458 X14459 X14460 AF466621 AF466622 AF466623 AF466624 AF466625 AF466626 AF466627 AF466628 AF466629 AF466630 AF466631 AF466632 AF466633 AF466634 AF466635 AF466636 AF466637 AF466638 AF466639 AF466640 AF466641 AF466642 AF466643 AF466644 AF466645 AE001572 AE014297 AE014297 AE014297 AE014297 AE014297 AY058658 BT021332 M14549 K03517
PIR	S00835
RefSeq	NP_476825.1 NP_731111.1 NP_731113.2 NP_788587.1 NP_788588.1
UniGene	Dm.3237
PDB	1ZQ3
PDBsum	1ZQ3
ProteinModelPortal	P09081
SMR	P09081
BioGrid	66028
IntAct	P09081
MINT	MINT-302540
PRIDE	P09081
EnsemblMetazoa	FBtr0081668
GeneID	40830
KEGG	dme:Dmel_CG1034
CTD	40830
FlyBase	FBgn0000166
eggNOG	NOG133998
InParanoid	P09081
KO	K18659
OMA	RTGAINY
OrthoDB	EOG75F4DN
PhylomeDB	P09081
SignaLink	P09081
EvolutionaryTrace	P09081
GenomeRNAi	40830
NextBio	820810
Proteomes	UP000000803
Bgee	P09081
GO	GO:0005634 GO:0016015 GO:0003730 GO:0003705 GO:0043565 GO:0003700 GO:0045182 GO:0030371 GO:0007355 GO:0009948 GO:0008595 GO:0008358 GO:0017148 GO:0048477 GO:0045944 GO:0006357 GO:0006355 GO:0006417 GO:0007367 GO:0006366
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR009057
Pfam	PF00046
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000166 FB:FBgn0004053 MGI:MGI:102851 MGI:MGI:96174 PANTHER:PTN002518688 RGD:62387 UniProtKB:P14651 UniProtKB:P14652 UniProtKB:P31249	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0051481 MGI:MGI:102851 MGI:MGI:96174 PANTHER:PTN002518688 RGD:62387 UniProtKB:O43364 UniProtKB:P14652	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000166 MGI:MGI:102851 MGI:MGI:96175 PANTHER:PTN002518688 RGD:62387	F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102851 MGI:MGI:96174 MGI:MGI:96184 PANTHER:PTN002518688 UniProtKB:P14651	F	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:23910663^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:19959668^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:18271625^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007367	segment polarity determination	PMID:16280349^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:15882623^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:15882623^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0053100	P	Seeded From UniProt	complete
enables	GO:0030371	translation repressor activity	PMID:15882623^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0053100	F	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:15649476^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007355	anterior region determination	PMID:15649476^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:12808087^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12808087^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12808087^[8]	ECO:0000305	curator inference used in manual assertion	GO:0000981	C	Seeded From UniProt	complete
involved_in	GO:0008293	torso signaling pathway	PMID:10603346^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008293	torso signaling pathway	PMID:11493547^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9449676^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000039 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0191 UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
involved_in	GO:0009948	anterior/posterior axis specification	PMID:12867048^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0045182	translation regulator activity	PMID:12414187^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0008358	maternal determination of anterior/posterior axis, embryo	PMID:12142000^[14] PMID:11105896^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008595	anterior/posterior axis specification, embryo	PMID:10494038^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Rödel, CJ et al. (2013) MicroRNAs act as cofactors in bicoid-mediated translational repression. Curr. Biol. 23 1579-84 PubMed GONUTS page
↑ Löhr, U et al. (2009) Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains. Proc. Natl. Acad. Sci. U.S.A. 106 21695-700 PubMed GONUTS page
↑ Li, XY et al. (2008) Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol. 6 e27 PubMed GONUTS page
↑ Werz, C et al. (2005) Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila. Development 132 5343-52 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Cho, PF et al. (2005) A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell 121 411-23 PubMed GONUTS page
↑ ^7.0 ^7.1 Singh, N et al. (2005) Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster. Dev. Biol. 278 242-54 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Fu, D et al. (2003) Enhancer sequences influence the role of the amino-terminal domain of bicoid in transcription. Mol. Cell. Biol. 23 4439-48 PubMed GONUTS page
↑ Janody, F et al. (2000) Phosphorylation of bicoid on MAP-kinase sites: contribution to its interaction with the torso pathway. Development 127 279-89 PubMed GONUTS page
↑ Janody, F et al. (2001) Two distinct domains of Bicoid mediate its transcriptional downregulation by the Torso pathway. Development 128 2281-90 PubMed GONUTS page
↑ Mailhos, C et al. (1998) Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators. Development 125 937-47 PubMed GONUTS page
↑ Lynch, J & Desplan, C (2003) Evolution of development: beyond bicoid. Curr. Biol. 13 R557-9 PubMed GONUTS page
↑ Dean, KA et al. (2002) Translational repressors in Drosophila. Trends Genet. 18 572-7 PubMed GONUTS page
↑ Holloway, DM et al. (2002) Sharp borders from fuzzy gradients. Trends Genet. 18 385-7 PubMed GONUTS page
↑ Canon, J & Banerjee, U (2000) Runt and Lozenge function in Drosophila development. Semin. Cell Dev. Biol. 11 327-36 PubMed GONUTS page
↑ Baek, KH & Lee, KY () Signal transduction pathway for anterior-posterior development in Drosophila. J. Biomed. Sci. 6 314-9 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23910663-2] Rödel, CJ et al. (2013) MicroRNAs act as cofactors in bicoid-mediated translational repression. Curr. Biol. 23 1579-84 PubMed GONUTS page

[PMID:19959668-3] Löhr, U et al. (2009) Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains. Proc. Natl. Acad. Sci. U.S.A. 106 21695-700 PubMed GONUTS page

[PMID:18271625-4] Li, XY et al. (2008) Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol. 6 e27 PubMed GONUTS page

[PMID:16280349-5] Werz, C et al. (2005) Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila. Development 132 5343-52 PubMed GONUTS page

[PMID:15882623-6] 6.0 ^6.1 ^6.2 Cho, PF et al. (2005) A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell 121 411-23 PubMed GONUTS page

[PMID:15649476-7] 7.0 ^7.1 Singh, N et al. (2005) Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster. Dev. Biol. 278 242-54 PubMed GONUTS page

[PMID:12808087-8] 8.0 ^8.1 ^8.2 Fu, D et al. (2003) Enhancer sequences influence the role of the amino-terminal domain of bicoid in transcription. Mol. Cell. Biol. 23 4439-48 PubMed GONUTS page

[PMID:10603346-9] Janody, F et al. (2000) Phosphorylation of bicoid on MAP-kinase sites: contribution to its interaction with the torso pathway. Development 127 279-89 PubMed GONUTS page

[PMID:11493547-10] Janody, F et al. (2001) Two distinct domains of Bicoid mediate its transcriptional downregulation by the Torso pathway. Development 128 2281-90 PubMed GONUTS page

[PMID:9449676-11] Mailhos, C et al. (1998) Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators. Development 125 937-47 PubMed GONUTS page

[PMID:12867048-12] Lynch, J & Desplan, C (2003) Evolution of development: beyond bicoid. Curr. Biol. 13 R557-9 PubMed GONUTS page

[PMID:12414187-13] Dean, KA et al. (2002) Translational repressors in Drosophila. Trends Genet. 18 572-7 PubMed GONUTS page

[PMID:12142000-14] Holloway, DM et al. (2002) Sharp borders from fuzzy gradients. Trends Genet. 18 385-7 PubMed GONUTS page

[PMID:11105896-15] Canon, J & Banerjee, U (2000) Runt and Lozenge function in Drosophila development. Semin. Cell Dev. Biol. 11 327-36 PubMed GONUTS page

[PMID:10494038-16] Baek, KH & Lee, KY () Signal transduction pathway for anterior-posterior development in Drosophila. J. Biomed. Sci. 6 314-9 PubMed GONUTS page

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DROME:BCD

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