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This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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DROME:BCD

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) bcd
Protein Name(s) Homeotic protein bicoid

PRD-4

External Links
UniProt P09081
EMBL X07870
X14458
X14459
X14460
AF466621
AF466622
AF466623
AF466624
AF466625
AF466626
AF466627
AF466628
AF466629
AF466630
AF466631
AF466632
AF466633
AF466634
AF466635
AF466636
AF466637
AF466638
AF466639
AF466640
AF466641
AF466642
AF466643
AF466644
AF466645
AE001572
AE014297
AE014297
AE014297
AE014297
AE014297
AY058658
BT021332
M14549
K03517
PIR S00835
RefSeq NP_476825.1
NP_731111.1
NP_731113.2
NP_788587.1
NP_788588.1
UniGene Dm.3237
PDB 1ZQ3
PDBsum 1ZQ3
ProteinModelPortal P09081
SMR P09081
BioGrid 66028
IntAct P09081
MINT MINT-302540
PRIDE P09081
EnsemblMetazoa FBtr0081668
GeneID 40830
KEGG dme:Dmel_CG1034
CTD 40830
FlyBase FBgn0000166
eggNOG NOG133998
InParanoid P09081
KO K18659
OMA RTGAINY
OrthoDB EOG75F4DN
PhylomeDB P09081
SignaLink P09081
EvolutionaryTrace P09081
GenomeRNAi 40830
NextBio 820810
Proteomes UP000000803
Bgee P09081
GO GO:0005634
GO:0016015
GO:0003730
GO:0003705
GO:0043565
GO:0003700
GO:0045182
GO:0030371
GO:0007355
GO:0009948
GO:0008595
GO:0008358
GO:0017148
GO:0048477
GO:0045944
GO:0006357
GO:0006355
GO:0006417
GO:0007367
GO:0006366
Gene3D 1.10.10.60
InterPro IPR017970
IPR001356
IPR009057
Pfam PF00046
SMART SM00389
SUPFAM SSF46689
PROSITE PS00027
PS50071

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012287

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0371

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

PMID:18271625[1]

IDA: Inferred from Direct Assay

F

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356
InterPro:IPR009057

F

Seeded From UniProt

complete

GO:0003705

sequence-specific enhancer binding RNA polymerase II transcription factor activity

PMID:12808087[2]

IDA: Inferred from Direct Assay

F

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0694

F

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

GO:0003730

mRNA 3'-UTR binding

PMID:15882623[3]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:18271625[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10717484[4]

IPI: Inferred from Physical Interaction

FB:FBgn0263144

F

complete

GO:0003705

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

PMID:12808087[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10717484[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q7K480

F

complete

GO:0003723

RNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10717484[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q7K480

F

complete

GO:0003730

mRNA 3'-UTR binding

PMID:15882623[3]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11455422[5]

IPI: Inferred from Physical Interaction

FB:FBgn0024491

F

complete

GO:0005515

protein binding

PMID:10717484[4]

IPI: Inferred from Physical Interaction

FB:FBgn0263144

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10717484[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q7K480

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11455422[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VEX9

F

complete

GO:0005515

protein binding

PMID:10717484[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q7K480

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15882623[3]

IPI: Inferred from Physical Interaction

FB:FBgn0053100

F

complete

GO:0005515

protein binding

PMID:11455422[5]

IPI: Inferred from Physical Interaction

FB:FBgn0024491

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21170036[6]

IPI: Inferred from Physical Interaction

FB:FBgn0033813

F

complete

GO:0005515

protein binding

PMID:11455422[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VEX9

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

C

complete

GO:0005515

protein binding

PMID:15882623[3]

IPI: Inferred from Physical Interaction

FB:FBgn0053100

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

complete

GO:0005515

protein binding

PMID:21170036[6]

IPI: Inferred from Physical Interaction

FB:FBgn0033813

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

complete

GO:0005515

protein binding

PMID:22584054[7]

IPI: Inferred from Physical Interaction

UniProtKB:O97102

F

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:12808087[2]

IC: Inferred by Curator

GO:0003705

C

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-dependent

PMID:18271625[1]

IDA: Inferred from Direct Assay

P

complete

GO:0005634

nucleus

PMID:12808087[2]

IC: Inferred by Curator

GO:0003705

C

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

P

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012287

P

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

P

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

complete

GO:0006355

regulation of transcription, DNA-templated

PMID:11700289[8]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

PMID:11700289[8]

NAS: Non-traceable Author Statement

P

complete

GO:0006355

regulation of transcription, DNA-templated

PMID:19959668[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

PMID:11845195[10]

NAS: Non-traceable Author Statement

P

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

PMID:11845195[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006417

regulation of translation

PMID:12414187[11]

TAS: Traceable Author Statement

P

complete

GO:0006417

regulation of translation

PMID:12414187[11]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007355

anterior region determination

PMID:15649476[12]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007355

anterior region determination

PMID:15649476[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007367

segment polarity determination

PMID:16280349[13]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007367

segment polarity determination

PMID:16280349[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008358

maternal determination of anterior/posterior axis, embryo

PMID:11105896[14]

TAS: Traceable Author Statement

P

complete

GO:0008358

maternal determination of anterior/posterior axis, embryo

PMID:11105896[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008358

maternal determination of anterior/posterior axis, embryo

PMID:11691830[15]

NAS: Non-traceable Author Statement

P

complete

GO:0008358

maternal determination of anterior/posterior axis, embryo

PMID:11691830[15]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008358

maternal determination of anterior/posterior axis, embryo

PMID:12142000[16]

TAS: Traceable Author Statement

P

complete

GO:0008358

maternal determination of anterior/posterior axis, embryo

PMID:12142000[16]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008595

anterior/posterior axis specification, embryo

PMID:10494038[17]

TAS: Traceable Author Statement

P

complete

GO:0008595

anterior/posterior axis specification, embryo

PMID:10494038[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008595

anterior/posterior axis specification, embryo

PMID:11700289[8]

NAS: Non-traceable Author Statement

P

complete

GO:0008595

anterior/posterior axis specification, embryo

PMID:11700289[8]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008595

anterior/posterior axis specification, embryo

PMID:11845195[10]

NAS: Non-traceable Author Statement

P

complete

GO:0008595

anterior/posterior axis specification, embryo

PMID:11845195[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008595

anterior/posterior axis specification, embryo

PMID:12879448[18]

TAS: Traceable Author Statement

P

complete

GO:0008595

anterior/posterior axis specification, embryo

PMID:12879448[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0009948

anterior/posterior axis specification

PMID:12867048[19]

TAS: Traceable Author Statement

P

complete

GO:0009948

anterior/posterior axis specification

PMID:12867048[19]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0016015

morphogen activity

PMID:11048731[20]

NAS: Non-traceable Author Statement

F

complete

GO:0016015

morphogen activity

PMID:11845195[10]

NAS: Non-traceable Author Statement

F

complete

GO:0016015

morphogen activity

PMID:11845195[10]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:11700289[8]

TAS: Traceable Author Statement

P

complete

GO:0017148

negative regulation of translation

PMID:11700289[8]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:12867048[19]

TAS: Traceable Author Statement

P

complete

GO:0017148

negative regulation of translation

PMID:12867048[19]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:15882623[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0053100

P

complete

GO:0017148

negative regulation of translation

PMID:15882623[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0053100

P

Seeded From UniProt

complete

GO:0030371

translation repressor activity

PMID:15882623[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0053100

F

complete

GO:0017148

negative regulation of translation

PMID:23910663[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

complete

GO:0030371

translation repressor activity

PMID:15882623[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0053100

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

Seeded From UniProt

complete

GO:0045182

translation regulator activity

PMID:12414187[11]

TAS: Traceable Author Statement

F

complete

GO:0045182

translation regulator activity

PMID:12414187[11]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:12808087[2]

IDA: Inferred from Direct Assay

P

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:12808087[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:15649476[12]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:9449676[22]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:15649476[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Li, XY et al. (2008) Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol. 6 e27 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Fu, D et al. (2003) Enhancer sequences influence the role of the amino-terminal domain of bicoid in transcription. Mol. Cell. Biol. 23 4439-48 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Cho, PF et al. (2005) A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell 121 411-23 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Zhu, W & Hanes, SD (2000) Identification of drosophila bicoid-interacting proteins using a custom two-hybrid selection. Gene 245 329-39 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Zhu, W et al. (2001) Drosophila SAP18, a member of the Sin3/Rpd3 histone deacetylase complex, interacts with Bicoid and inhibits its activity. Dev. Genes Evol. 211 109-17 PubMed GONUTS page
  6. 6.0 6.1 Liu, J & Ma, J (2011) Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos. Nat. Cell Biol. 13 22-9 PubMed GONUTS page
  7. Liu, J & Ma, J (2012) Drosophila Bicoid is a substrate of sumoylation and its activator function is subject to inhibition by this post-translational modification. FEBS Lett. 586 1719-23 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 Lall, S & Patel, NH (2001) Conservation and divergence in molecular mechanisms of axis formation. Annu. Rev. Genet. 35 407-37 PubMed GONUTS page
  9. Löhr, U et al. (2009) Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains. Proc. Natl. Acad. Sci. U.S.A. 106 21695-700 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 10.5 Patel, NH & Lall, S (2002) Precision patterning. Nature 415 748-9 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 Dean, KA et al. (2002) Translational repressors in Drosophila. Trends Genet. 18 572-7 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 Singh, N et al. (2005) Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster. Dev. Biol. 278 242-54 PubMed GONUTS page
  13. 13.0 13.1 Werz, C et al. (2005) Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila. Development 132 5343-52 PubMed GONUTS page
  14. 14.0 14.1 Canon, J & Banerjee, U (2000) Runt and Lozenge function in Drosophila development. Semin. Cell Dev. Biol. 11 327-36 PubMed GONUTS page
  15. 15.0 15.1 Courey, AJ & Jia, S (2001) Transcriptional repression: the long and the short of it. Genes Dev. 15 2786-96 PubMed GONUTS page
  16. 16.0 16.1 Holloway, DM et al. (2002) Sharp borders from fuzzy gradients. Trends Genet. 18 385-7 PubMed GONUTS page
  17. 17.0 17.1 Baek, KH & Lee, KY () Signal transduction pathway for anterior-posterior development in Drosophila. J. Biomed. Sci. 6 314-9 PubMed GONUTS page
  18. 18.0 18.1 López-Schier, H (2003) The polarisation of the anteroposterior axis in Drosophila. Bioessays 25 781-91 PubMed GONUTS page
  19. 19.0 19.1 19.2 19.3 Lynch, J & Desplan, C (2003) Evolution of development: beyond bicoid. Curr. Biol. 13 R557-9 PubMed GONUTS page
  20. Meier, P et al. (2000) Apoptosis in development. Nature 407 796-801 PubMed GONUTS page
  21. Rödel, CJ et al. (2013) MicroRNAs act as cofactors in bicoid-mediated translational repression. Curr. Biol. 23 1579-84 PubMed GONUTS page
  22. Mailhos, C et al. (1998) Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators. Development 125 937-47 PubMed GONUTS page