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DICDI:PK2

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Species (Taxon ID) Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s) pkgB (synonyms: pfkA, pkbr1)
Protein Name(s) Protein kinase 2

PK2

External Links
UniProt P28178
EMBL M59744
AAFI02000158
PIR A38578
RefSeq XP_635853.1
ProteinModelPortal P28178
STRING 44689.DDB0191365
PRIDE P28178
EnsemblProtists DDB0191365
EAL62350
GeneID 8627509
KEGG ddi:DDB_G0290157
dictyBase DDB_G0290157
eggNOG COG0515
InParanoid P28178
KO K13303
OMA EGHICIT
PhylomeDB P28178
BRENDA 2.7.11.1
PRO PR:P28178
Proteomes UP000002195
UP000002195
GO GO:0005737
GO:0005886
GO:0005524
GO:0004691
GO:0043327
GO:0006468
GO:0050920
GO:0030587
GO:0031288
InterPro IPR000961
IPR011009
IPR017892
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
PF00433
SMART SM00133
SM00220
SUPFAM SSF56112
PROSITE PS51285
PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006468

protein phosphorylation

PMID:20200230[1]

ECO:0000315

P

Figure 1E

complete
CACAO 11054

acts_upstream_of_or_within

GO:0046580

negative regulation of Ras protein signal transduction

PMID:20493808[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P54644

P

has_regulation_target:(UniProtKB:P32253)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050920

regulation of chemotaxis

PMID:22081140[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P54644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0110094

polyphosphate-mediated signaling

PMID:28584190[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P54644

P

Seeded From UniProt

complete

involved_in

GO:1903013

response to differentiation-inducing factor 1

PMID:25518940[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043327

chemotaxis to cAMP

PMID:10873800[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P54644

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031288

sorocarp morphogenesis

PMID:10873800[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030587

sorocarp development

PMID:21335531[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

PMID:18635356[8]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P54644

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:10873800[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:10873800[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004691

cAMP-dependent protein kinase activity

PMID:10873800[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1920336
PANTHER:PTN000682065
UniProtKB:O75582
UniProtKB:O75676

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020412
FB:FBgn0283472
MGI:MGI:1270849
MGI:MGI:1920336
MGI:MGI:1927343
PANTHER:PTN000682065
RGD:1305144
RGD:620683
TAIR:locus:2077843
TAIR:locus:2077873
UniProtKB:O75582
UniProtKB:O75676
dictyBase:DDB_G0290157

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0283473
PANTHER:PTN000682065
PomBase:SPCC24B10.07
SGD:S000000232
TAIR:locus:2077873
UniProtKB:O75582
UniProtKB:P23443
UniProtKB:Q8I4W3

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1920336
PANTHER:PTN000682065
RGD:620683
SGD:S000004710
TAIR:locus:2077843
TAIR:locus:2077873
UniProtKB:O75582
UniProtKB:O75676
UniProtKB:P23443

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020412
FB:FBgn0283473
MGI:MGI:1920336
PANTHER:PTN000682065
PomBase:SPCC24B10.07
SGD:S000000232
TAIR:locus:2077873
UniProtKB:O75582
UniProtKB:O75676
UniProtKB:Q8I4W3

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000961

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0145

P

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Liao, XH et al. (2010) Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2. J. Cell. Sci. 123 983-92 PubMed GONUTS page
  2. Charest, PG et al. (2010) A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev. Cell 18 737-49 PubMed GONUTS page
  3. Kortholt, A et al. (2011) Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification. EMBO Rep. 12 1273-9 PubMed GONUTS page
  4. Suess, PM et al. (2017) Extracellular polyphosphate signals through Ras and Akt to prime cells for development. J. Cell. Sci. 130 2394-2404 PubMed GONUTS page
  5. Sugden, C et al. (2015) The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes. Mol. Biol. Cell 26 805-20 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Meili, R et al. (2000) A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium. Curr. Biol. 10 708-17 PubMed GONUTS page
  7. Ochiai, H et al. (2011) Protein kinase B gene homologue pkbR1 performs one of its roles at first finger stage of Dictyostelium. Eukaryotic Cell 10 512-20 PubMed GONUTS page
  8. Kamimura, Y et al. (2008) PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr. Biol. 18 1034-43 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page