GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
DICDI:PK2
Contents
Species (Taxon ID) | Dictyostelium discoideum (Slime mold). (44689) | |
Gene Name(s) | pkgB (synonyms: pfkA, pkbr1) | |
Protein Name(s) | Protein kinase 2
PK2 | |
External Links | ||
UniProt | P28178 | |
EMBL | M59744 AAFI02000158 | |
PIR | A38578 | |
RefSeq | XP_635853.1 | |
ProteinModelPortal | P28178 | |
STRING | 44689.DDB0191365 | |
PRIDE | P28178 | |
EnsemblProtists | DDB0191365 EAL62350 | |
GeneID | 8627509 | |
KEGG | ddi:DDB_G0290157 | |
dictyBase | DDB_G0290157 | |
eggNOG | COG0515 | |
InParanoid | P28178 | |
KO | K13303 | |
OMA | EGHICIT | |
PhylomeDB | P28178 | |
BRENDA | 2.7.11.1 | |
PRO | PR:P28178 | |
Proteomes | UP000002195 UP000002195 | |
GO | GO:0005737 GO:0005886 GO:0005524 GO:0004691 GO:0043327 GO:0006468 GO:0050920 GO:0030587 GO:0031288 | |
InterPro | IPR000961 IPR011009 IPR017892 IPR000719 IPR017441 IPR002290 IPR008271 | |
Pfam | PF00069 PF00433 | |
SMART | SM00133 SM00220 | |
SUPFAM | SSF56112 | |
PROSITE | PS51285 PS00107 PS50011 PS00108 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0006468 |
protein phosphorylation |
ECO:0000315 |
P |
Figure 1E |
complete | |||||
acts_upstream_of_or_within |
GO:0046580 |
negative regulation of Ras protein signal transduction |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P32253) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0050920 |
regulation of chemotaxis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0110094 |
polyphosphate-mediated signaling |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903013 |
response to differentiation-inducing factor 1 |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043327 |
chemotaxis to cAMP |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0031288 |
sorocarp morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030587 |
sorocarp development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004691 |
cAMP-dependent protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1920336 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0020412 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0283473 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1920336 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0020412 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006935 |
chemotaxis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Liao, XH et al. (2010) Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2. J. Cell. Sci. 123 983-92 PubMed GONUTS page
- ↑ Charest, PG et al. (2010) A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev. Cell 18 737-49 PubMed GONUTS page
- ↑ Kortholt, A et al. (2011) Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification. EMBO Rep. 12 1273-9 PubMed GONUTS page
- ↑ Suess, PM et al. (2017) Extracellular polyphosphate signals through Ras and Akt to prime cells for development. J. Cell. Sci. 130 2394-2404 PubMed GONUTS page
- ↑ Sugden, C et al. (2015) The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes. Mol. Biol. Cell 26 805-20 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Meili, R et al. (2000) A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium. Curr. Biol. 10 708-17 PubMed GONUTS page
- ↑ Ochiai, H et al. (2011) Protein kinase B gene homologue pkbR1 performs one of its roles at first finger stage of Dictyostelium. Eukaryotic Cell 10 512-20 PubMed GONUTS page
- ↑ Kamimura, Y et al. (2008) PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr. Biol. 18 1034-43 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
n
p