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PMID:18635356
| Citation |
Kamimura, Y, Xiong, Y, Iglesias, PA, Hoeller, O, Bolourani, P and Devreotes, PN (2008) PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr. Biol. 18:1034-43 |
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| Abstract |
Studies show that high phosphotidylinositol 3,4,5-trisphosphate (PIP(3)) promotes cytoskeletal rearrangements and alters cell motility and chemotaxis, possibly through activation of protein kinase Bs (PKBs). However, chemotaxis can still occur in the absence of PIP(3), and the identities of the PIP(3)-independent pathways remain unknown. |
| Links |
PubMed Online version:10.1016/j.cub.2008.06.068 |
| Keywords |
Amino Acid Motifs; Animals; Chemotaxis/physiology; Dictyostelium/physiology; Enzyme Activation; GTP-Binding Proteins/physiology; Hydrophobic and Hydrophilic Interactions; Models, Biological; Phosphatidylinositol Phosphates/metabolism; Phosphorylation; Protein-Serine-Threonine Kinases/physiology; Proto-Oncogene Proteins c-akt/chemistry; Proto-Oncogene Proteins c-akt/physiology; Protozoan Proteins/chemistry; Protozoan Proteins/physiology; Signal Transduction; Substrate Specificity |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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References
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