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DICDI:KRAC

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Species (Taxon ID) Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s) pkbA (synonyms: akt, dagA)
Protein Name(s) RAC family serine/threonine-protein kinase homolog
External Links
UniProt P54644
EMBL U15210
AAFI02000004
RefSeq XP_646888.1
ProteinModelPortal P54644
BioGrid 1241576
STRING 44689.DDB0191195
PRIDE P54644
EnsemblProtists DDB0191195
EAL72899
GeneID 8616573
KEGG ddi:DDB_G0268620
dictyBase DDB_G0268620
eggNOG COG0515
InParanoid P54644
KO K04456
OMA HIVEHNE
PhylomeDB P54644
PRO PR:P54644
Proteomes UP000002195
UP000002195
GO GO:0005938
GO:0005524
GO:0004691
GO:0019887
GO:0004674
GO:0006935
GO:0043327
GO:0031154
GO:0030010
GO:0007163
GO:0044351
GO:0000281
GO:0031036
GO:0050765
GO:0048015
GO:0006468
GO:0050920
GO:0045859
Gene3D 2.30.29.30
InterPro IPR000961
IPR011009
IPR011993
IPR001849
IPR017892
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00169
PF00069
PF00433
SMART SM00233
SM00133
SM00220
SUPFAM SSF56112
PROSITE PS51285
PS50003
PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006468

protein phosphorylation

PMID:20200230[1]

ECO:0000315

P

Figure 1D

complete
CACAO 11053

enables

GO:0005547

phosphatidylinositol-3,4,5-trisphosphate binding

PMID:20547830[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046580

negative regulation of Ras protein signal transduction

PMID:20493808[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P28178

P

has_regulation_target:(UniProtKB:P32253)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032147

activation of protein kinase activity

PMID:11389841[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q55D99)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905303

positive regulation of macropinocytosis

PMID:11553719[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

PMID:11389841[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(UniProtKB:Q55D99)

Seeded From UniProt

complete

involved_in

GO:1903013

response to differentiation-inducing factor 1

PMID:25518940[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031252

cell leading edge

PMID:19346484[7]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(GO:0051602)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090382

phagosome maturation

PMID:11256995[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

PMID:20493808[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(UniProtKB:Q54XY4)

Seeded From UniProt

complete

involved_in

GO:0042542

response to hydrogen peroxide

PMID:10192918[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005547

phosphatidylinositol-3,4,5-trisphosphate binding

PMID:10192918[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050920

regulation of chemotaxis

PMID:22081140[10]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P28178

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0110094

polyphosphate-mediated signaling

PMID:28584190[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050765

negative regulation of phagocytosis

PMID:22266904[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0044351

macropinocytosis

PMID:22266904[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043327

chemotaxis to cAMP

PMID:10873800[13]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P28178

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043327

chemotaxis to cAMP

PMID:21169559[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030010

establishment of cell polarity

PMID:21169559[14]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8T9S7

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

PMID:21169559[14]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8T9S7

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

PMID:18635356[15]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P28178

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:10873800[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

PMID:16968699[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0005886

plasma membrane

PMID:15470246[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0005829

cytosol

PMID:15470246[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:9226449[18]

ECO:0000305

curator inference used in manual assertion

GO:0004674

F

Seeded From UniProt

complete

enables

GO:0004691

cAMP-dependent protein kinase activity

PMID:10873800[13]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:17635933[19]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:10205164[20]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000281

mitotic cytokinesis

PMID:21169559[14]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8T9S7

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[21]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003744
FB:FBgn0010379
MGI:MGI:97601
PANTHER:PTN000683254
PomBase:SPAC1B9.02c
PomBase:SPAC22E12.14c
PomBase:SPAPB18E9.02c
RGD:3395
RGD:3399
RGD:61925
RGD:620968
RGD:67383
SGD:S000000201
UniProtKB:O15530
UniProtKB:P31749
UniProtKB:Q15208
UniProtKB:Q9NRM7
UniProtKB:Q9Y2H1

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:21873635[21]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87986
PANTHER:PTN000683254
RGD:2081
RGD:3395
RGD:3399
RGD:3668
RGD:61925
SGD:S000001609
SGD:S000001861
SGD:S000002898
SGD:S000005460
UniProtKB:A0A1D5PUY5
UniProtKB:P31749
UniProtKB:P41743
UniProtKB:Q02156
UniProtKB:Q05513
UniProtKB:Q05655
WB:WBGene00000102
WB:WBGene00000103
WB:WBGene00004033
WB:WBGene00004034
WB:WBGene00004789
WB:WBGene00006599

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[21]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003091
FB:FBgn0003744
FB:FBgn0010379
FB:FBgn0260399
FB:FBgn0261854
MGI:MGI:104874
MGI:MGI:2182368
MGI:MGI:87986
MGI:MGI:894676
MGI:MGI:97595
MGI:MGI:97596
MGI:MGI:97599
MGI:MGI:97602
PANTHER:PTN000683254
PomBase:SPAC1B9.02c
PomBase:SPAC22E12.14c
PomBase:SPAC24B11.11c
PomBase:SPAC821.12
PomBase:SPAPB18E9.02c
PomBase:SPCC576.15c
RGD:2081
RGD:2082
RGD:3399
RGD:3668
RGD:620146
RGD:620968
RGD:62390
SGD:S000001248
SGD:S000001609
SGD:S000001861
SGD:S000002898
SGD:S000003324
SGD:S000005105
SGD:S000005460
SGD:S000006315
TAIR:locus:2088515
UniProtKB:O15530
UniProtKB:O95835
UniProtKB:P05771
UniProtKB:P17252
UniProtKB:P31749
UniProtKB:P31751
UniProtKB:P41743
UniProtKB:Q02156
UniProtKB:Q04759
UniProtKB:Q05513
UniProtKB:Q05655
UniProtKB:Q09013
UniProtKB:Q15208
UniProtKB:Q16512
UniProtKB:Q16513
UniProtKB:Q96GX5
UniProtKB:Q9NRM7
UniProtKB:Q9XF67
UniProtKB:Q9Y243
UniProtKB:Q9Y2H1
WB:WBGene00000102
WB:WBGene00000103
WB:WBGene00004034
WB:WBGene00004789
WB:WBGene00006599
dictyBase:DDB_G0268620

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000961
InterPro:IPR017892

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR017441
InterPro:IPR017892

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR008271
InterPro:IPR017892

P

Seeded From UniProt

complete

involved_in

GO:0048015

phosphatidylinositol-mediated signaling

PMID:15366706[22]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045859

regulation of protein kinase activity

PMID:15473840[23]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031154

culmination involved in sorocarp development

PMID:15473840[23]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031036

myosin II filament assembly

PMID:15473840[23]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019887

protein kinase regulator activity

PMID:15473840[23]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007163

establishment or maintenance of cell polarity

PMID:15473840[23]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0145

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Liao, XH et al. (2010) Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2. J. Cell. Sci. 123 983-92 PubMed GONUTS page
  2. Zhang, P et al. (2010) Proteomic identification of phosphatidylinositol (3,4,5) triphosphate-binding proteins in Dictyostelium discoideum. Proc. Natl. Acad. Sci. U.S.A. 107 11829-34 PubMed GONUTS page
  3. 3.0 3.1 Charest, PG et al. (2010) A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev. Cell 18 737-49 PubMed GONUTS page
  4. 4.0 4.1 Chung, CY et al. (2001) Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7 937-47 PubMed GONUTS page
  5. Rupper, A et al. (2001) Sequential activities of phosphoinositide 3-kinase, PKB/Aakt, and Rab7 during macropinosome formation in Dictyostelium. Mol. Biol. Cell 12 2813-24 PubMed GONUTS page
  6. Sugden, C et al. (2015) The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes. Mol. Biol. Cell 26 805-20 PubMed GONUTS page
  7. Sato, MJ et al. (2009) Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling. Proc. Natl. Acad. Sci. U.S.A. 106 6667-72 PubMed GONUTS page
  8. Rupper, AC et al. (2001) p110-related PI 3-kinases regulate phagosome-phagosome fusion and phagosomal pH through a PKB/Akt dependent pathway in Dictyostelium. J. Cell. Sci. 114 1283-95 PubMed GONUTS page
  9. 9.0 9.1 Tanaka, K et al. (1999) Identification of protein kinase B (PKB) as a phosphatidylinositol 3,4,5-trisphosphate binding protein in Dictyostelium discoideum. Biosci. Biotechnol. Biochem. 63 368-72 PubMed GONUTS page
  10. Kortholt, A et al. (2011) Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification. EMBO Rep. 12 1273-9 PubMed GONUTS page
  11. Suess, PM et al. (2017) Extracellular polyphosphate signals through Ras and Akt to prime cells for development. J. Cell. Sci. 130 2394-2404 PubMed GONUTS page
  12. 12.0 12.1 Rosel, D et al. (2012) TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing. J. Cell. Sci. 125 37-48 PubMed GONUTS page
  13. 13.0 13.1 13.2 Meili, R et al. (2000) A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium. Curr. Biol. 10 708-17 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 Tang, M et al. (2011) Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Mol. Biol. Cell 22 437-47 PubMed GONUTS page
  15. Kamimura, Y et al. (2008) PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr. Biol. 18 1034-43 PubMed GONUTS page
  16. Han, JW et al. (2006) Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium. J. Biol. Chem. 281 35224-34 PubMed GONUTS page
  17. 17.0 17.1 Gao, T et al. (2004) A cell number counting factor regulates Akt/protein kinase B to regulate Dictyostelium discoideum group size. Eukaryotic Cell 3 1176-84 PubMed GONUTS page
  18. Oohata, AA et al. (1997) A novel prespore-cell-inducing factor in Dictyostelium discoideum induces cell division of prespore cells. Development 124 2781-7 PubMed GONUTS page
  19. Sasaki, AT et al. (2007) G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J. Cell Biol. 178 185-91 PubMed GONUTS page
  20. Meili, R et al. (1999) Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J. 18 2092-105 PubMed GONUTS page
  21. 21.0 21.1 21.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  22. Van Haastert, PJ & Devreotes, PN (2004) Chemotaxis: signalling the way forward. Nat. Rev. Mol. Cell Biol. 5 626-34 PubMed GONUTS page
  23. 23.0 23.1 23.2 23.3 23.4 Manahan, CL et al. (2004) Chemoattractant signaling in dictyostelium discoideum. Annu. Rev. Cell Dev. Biol. 20 223-53 PubMed GONUTS page