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DICDI:KRAC
Contents
Species (Taxon ID) | Dictyostelium discoideum (Slime mold). (44689) | |
Gene Name(s) | pkbA (synonyms: akt, dagA) | |
Protein Name(s) | RAC family serine/threonine-protein kinase homolog | |
External Links | ||
UniProt | P54644 | |
EMBL | U15210 AAFI02000004 | |
RefSeq | XP_646888.1 | |
ProteinModelPortal | P54644 | |
BioGrid | 1241576 | |
STRING | 44689.DDB0191195 | |
PRIDE | P54644 | |
EnsemblProtists | DDB0191195 EAL72899 | |
GeneID | 8616573 | |
KEGG | ddi:DDB_G0268620 | |
dictyBase | DDB_G0268620 | |
eggNOG | COG0515 | |
InParanoid | P54644 | |
KO | K04456 | |
OMA | HIVEHNE | |
PhylomeDB | P54644 | |
PRO | PR:P54644 | |
Proteomes | UP000002195 UP000002195 | |
GO | GO:0005938 GO:0005524 GO:0004691 GO:0019887 GO:0004674 GO:0006935 GO:0043327 GO:0031154 GO:0030010 GO:0007163 GO:0044351 GO:0000281 GO:0031036 GO:0050765 GO:0048015 GO:0006468 GO:0050920 GO:0045859 | |
Gene3D | 2.30.29.30 | |
InterPro | IPR000961 IPR011009 IPR011993 IPR001849 IPR017892 IPR000719 IPR017441 IPR002290 IPR008271 | |
Pfam | PF00169 PF00069 PF00433 | |
SMART | SM00233 SM00133 SM00220 | |
SUPFAM | SSF56112 | |
PROSITE | PS51285 PS50003 PS00107 PS50011 PS00108 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0006468 |
protein phosphorylation |
ECO:0000315 |
P |
Figure 1D |
complete | |||||
enables |
GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0046580 |
negative regulation of Ras protein signal transduction |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P32253) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0032147 |
activation of protein kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q55D99) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1905303 |
positive regulation of macropinocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:Q55D99) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903013 |
response to differentiation-inducing factor 1 |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0031252 |
cell leading edge |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(GO:0051602) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0090382 |
phagosome maturation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:Q54XY4) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042542 |
response to hydrogen peroxide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050920 |
regulation of chemotaxis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0110094 |
polyphosphate-mediated signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050765 |
negative regulation of phagocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0044351 |
macropinocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043327 |
chemotaxis to cAMP |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043327 |
chemotaxis to cAMP |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030010 |
establishment of cell polarity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005938 |
cell cortex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000305 |
curator inference used in manual assertion |
GO:0004674 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004691 |
cAMP-dependent protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0000281 |
mitotic cytokinesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003744 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87986 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003091 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048015 |
phosphatidylinositol-mediated signaling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045859 |
regulation of protein kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031154 |
culmination involved in sorocarp development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031036 |
myosin II filament assembly |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019887 |
protein kinase regulator activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007163 |
establishment or maintenance of cell polarity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006935 |
chemotaxis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Liao, XH et al. (2010) Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2. J. Cell. Sci. 123 983-92 PubMed GONUTS page
- ↑ Zhang, P et al. (2010) Proteomic identification of phosphatidylinositol (3,4,5) triphosphate-binding proteins in Dictyostelium discoideum. Proc. Natl. Acad. Sci. U.S.A. 107 11829-34 PubMed GONUTS page
- ↑ 3.0 3.1 Charest, PG et al. (2010) A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev. Cell 18 737-49 PubMed GONUTS page
- ↑ 4.0 4.1 Chung, CY et al. (2001) Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7 937-47 PubMed GONUTS page
- ↑ Rupper, A et al. (2001) Sequential activities of phosphoinositide 3-kinase, PKB/Aakt, and Rab7 during macropinosome formation in Dictyostelium. Mol. Biol. Cell 12 2813-24 PubMed GONUTS page
- ↑ Sugden, C et al. (2015) The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes. Mol. Biol. Cell 26 805-20 PubMed GONUTS page
- ↑ Sato, MJ et al. (2009) Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling. Proc. Natl. Acad. Sci. U.S.A. 106 6667-72 PubMed GONUTS page
- ↑ Rupper, AC et al. (2001) p110-related PI 3-kinases regulate phagosome-phagosome fusion and phagosomal pH through a PKB/Akt dependent pathway in Dictyostelium. J. Cell. Sci. 114 1283-95 PubMed GONUTS page
- ↑ 9.0 9.1 Tanaka, K et al. (1999) Identification of protein kinase B (PKB) as a phosphatidylinositol 3,4,5-trisphosphate binding protein in Dictyostelium discoideum. Biosci. Biotechnol. Biochem. 63 368-72 PubMed GONUTS page
- ↑ Kortholt, A et al. (2011) Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification. EMBO Rep. 12 1273-9 PubMed GONUTS page
- ↑ Suess, PM et al. (2017) Extracellular polyphosphate signals through Ras and Akt to prime cells for development. J. Cell. Sci. 130 2394-2404 PubMed GONUTS page
- ↑ 12.0 12.1 Rosel, D et al. (2012) TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing. J. Cell. Sci. 125 37-48 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Meili, R et al. (2000) A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium. Curr. Biol. 10 708-17 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 Tang, M et al. (2011) Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Mol. Biol. Cell 22 437-47 PubMed GONUTS page
- ↑ Kamimura, Y et al. (2008) PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr. Biol. 18 1034-43 PubMed GONUTS page
- ↑ Han, JW et al. (2006) Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium. J. Biol. Chem. 281 35224-34 PubMed GONUTS page
- ↑ 17.0 17.1 Gao, T et al. (2004) A cell number counting factor regulates Akt/protein kinase B to regulate Dictyostelium discoideum group size. Eukaryotic Cell 3 1176-84 PubMed GONUTS page
- ↑ Oohata, AA et al. (1997) A novel prespore-cell-inducing factor in Dictyostelium discoideum induces cell division of prespore cells. Development 124 2781-7 PubMed GONUTS page
- ↑ Sasaki, AT et al. (2007) G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J. Cell Biol. 178 185-91 PubMed GONUTS page
- ↑ Meili, R et al. (1999) Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J. 18 2092-105 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Van Haastert, PJ & Devreotes, PN (2004) Chemotaxis: signalling the way forward. Nat. Rev. Mol. Cell Biol. 5 626-34 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 23.3 23.4 Manahan, CL et al. (2004) Chemoattractant signaling in dictyostelium discoideum. Annu. Rev. Cell Dev. Biol. 20 223-53 PubMed GONUTS page
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- GO:0018105 ! peptidyl-serine phosphorylation
- GO:0090382 ! phagosome maturation
- GO:0048015 ! phosphatidylinositol-mediated signaling
- GO:0005547 ! phosphatidylinositol-3,4,5-trisphosphate binding
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0110094 ! polyphosphate-mediated signaling
- GO:1905303 ! positive regulation of macropinocytosis
- GO:0004672 ! protein kinase activity
- GO:0019887 ! protein kinase regulator activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
r